Abstract:
AIM:The clinical significance of Fas and FasL in hormone-sensitive carcinomas has been reported. Our objective was to evaluate the expression of apoptosis-regulating genes Fas and FasL in Indian breast cancer and fibroadenoma patients in relation to hormone receptor status. STUDY DESIGN:Retrospective. MATERIALS AND METHODS:Paraffin-embedded tissue samples from 63 untreated female patients with invasive ductal carcinoma (IDC) and 32 female patients with fibroadenoma were studied. Expression of Fas and FasL was evaluated using immunohistochemical staining method. STATISTICAL ANALYSIS:Fisher's exact test and nonparametric correlation test (Spearman rank correlation test) were performed. RESULT:Fas was detected in 97% of the fibroadenomas and there was a slight decrease in levels of expression with histological grades of IDC. The expression of FasL was detected in 75% fibroadenomas and its expression increased in IDC. There was no correlation between Fas, FasL expression and hormone receptor status. Strong expression of Fas in myoepithelial cells was noted in 12 out of 32 fibroadenoma cases. CONCLUSION:Expression of Fas and FasL alone is unlikely to be important as a predictive factor as they express in both normal and malignant breast epithelium. But strong expression of Fas in myoepithelial cells along with strong nuclear expression of FasL in epithelial cells of fibroadenoma could be useful as an early predictive factor for onset of malignancy.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Ranade KJ,Nerurkar AV,Phulpagar MD,Shirsat NVdoi
10.4103/0019-509X.98921subject
Has Abstractpub_date
2012-01-01 00:00:00pages
60-5issue
1eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2012_49_1_60_98921journal_volume
49pub_type
杂志文章abstract:INTRODUCTION:Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue ...
journal_title:Indian journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.4103/ijc.IJC_174_17
更新日期:2017-01-01 00:00:00
abstract:AIM OF STUDY:To investigate the trend of expression of liver function test enzymes and other biochemical changes during gallbladder carcinogenesis. MATERIALS AND METHODS:Eight hundred and seventy-eight gallbladder disease patients were selected to study the liver function test enzymes and routine blood biochemical cha...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.98938
更新日期:2012-01-01 00:00:00
abstract::This note presents a brief account of the ideas and efforts of V.R. Khanolkar in the period 1952-1962 to develop the Indian Cancer Research Centre into a "center of excellence". Khanolkar, who is recognized as a pioneer in cancer research in India, focused on developing multidisciplinary medical research and mentored ...
journal_title:Indian journal of cancer
pub_type: 传,历史文章,杂志文章
doi:10.4103/ijc.IJC_14_19
更新日期:2019-10-01 00:00:00
abstract::Over the last 11 years, 101 patients of Wilms tumor were treated at our hospital. Of these, 7 had bilateral Wilms tumors (BWT). The first two patients were referred in terminal stages and died. Of the latter five, three have survived while one is on treatment. One patient succumbed to liver metastasis, he had stage II...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::The incidence of late complications for different size of dose per fraction is analysed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1 and 52 cases with T2 lesions. Radical radiotherapy was given with three different regimens having dose per fraction as 3.33, 2.5 an...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:When microwave ablation (MWA) is used for subpleural lesions, severe pain was the common side effect under the local anesthesia conditions during the procedure and postprocedure. To study the pain relief effect of artificial pneumothorax in the treatment of subpleural lung tumors with MWA. MATERIALS AND MET...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.172519
更新日期:2015-12-01 00:00:00
abstract::Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors incl...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.76625
更新日期:2011-01-01 00:00:00
abstract:Background:Despite the advances in screening during the past decades, colorectal cancer (CRC) still is a leading cause of cancer deaths worldwide. Therefore, the development of new diagnostic methods is necessary. Aim:The aim of this study was to compare methylation changes of SRY-Box 21 (SOX21) gene promoter in tumor...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_542_18
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Non-urothelial bladder tumors (NUBTs) are uncommon accounting for approximately 10% of the total urinary bladder tumors while 90% are urothelial in origin. There are very limited comprehensive studies on NUBTs. AIMS AND OBJECTIVES:The objectives of the study were to analyze the clinicopathological and immun...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_459_17
更新日期:2019-07-01 00:00:00
abstract::This report documents the occurrence of an extragonadal malignant teratoma on the sole of the foot, in a young male. The patient also developed a groin nodule showing the same histology. The testes, retroperitoneum and mediastinum, which are usual sites of germ cell tumours were all normal, and no other primary could ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Rat sarcoma viral oncogene homolog (RAS) and B-Raf murine sarcoma viral oncogene homolog B1 (BRAF) are members of the same signaling pathway (RAS-RAF-mitogen-activated protein kinase (MAPK) in colorectal cancer (CRC). It is generally assumed that BRAF mutations are seen only with wild-type RAS in CRC. But RAS and BRAF...
journal_title:Indian journal of cancer
pub_type:
doi:10.4103/ijc.IJC_430_18
更新日期:2019-04-01 00:00:00
abstract::Five cases of primary lymphoma of the brain are reported and the literature reviewed. The diverse clinical spectrum at presentation and variable response to therapy are few of its unique features. The literature is reviewed briefly and the importance of diagnosis at an early stage and prompt institution of therapy in ...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1991-06-01 00:00:00
abstract::Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:The standard of care of patients with cancer of cardia and esophagus still remains surgery in early stage. One of the most feared complications after such procedure is anastomotic leak. AIM:We present our experience with omental wrapping of anastomosis (omentoplasty) to decrease the anastomotic leak. SETTI...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::Since 1987, 560 patients have been treated in our department for carcinoma of thyroid with radioactive Iodine-131. Recently, we have come across a patient with bilateral pulmonary concentration of Iodine-131, that is visualised on Iodine-131 whole body scintiscan, whereas chest radiogram was negative. Respectively, th...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a well-known adverse effect of vincristine (VCR). Literature suggests that Asians are predisposed to develop SIADH following VCR administration. However, data regarding the occurrence of SIADH in children with malignancy are limited. This st...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_737_18
更新日期:2019-10-01 00:00:00
abstract::We report a rare case of 'metastatic invasive mole' to the spinal cord causing paraplegia in a 19-year-old woman. There are no such histologically proven reports in the literature since the use of the tumour marker, beta-subunit of human chorionic gonadotrophin (beta-HCG) and chemotherapy. We stress the importance of ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of patients of renal cell carcinoma (RCC) with inferior vena caval (IVC) thrombus treated by radical nephrectomy and IVC thrombectomy in terms of clinical and pathological factors and prognosis. MATERIALS AND METHODS:Sixty-three consecutive patients of RCC with IVC thrombus who underwen...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.35810
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Nonsmall cell lung cancer is the leading cause of cancer mortality worldwide because of distant metastasis and frequent recurrence. Only few reliable and easily accessible tumor markers have been clinically implemented to the early nonsmall cell cancer prognosis. OBJECTIVE:The purpose of this study is to de...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.172509
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.117023
更新日期:2013-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.151999
更新日期:2015-02-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175602
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Tamoxifen is being used in patients with estrogen receptor positive breast cancer as an adjuvant or palliative hormonal therapy. w0 estern studies have found a 30% incidence of gallstones in patients who are taking Tamoxifen and they have proved a significant association between the two. OBJECTIVES:The obje...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.49154
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Preoperative risk estimation evaluating mortality and morbidity might help surgical decision. AIMS:The aim of this study was to compare the sensitivities of physiologic and operative severity score for the enumeration of mortality and morbidity (POSSUM), portsmouth-POSSUM (P-POSSUM), colorectal-POSSUM (CR-P...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175318
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The three direct factors that could lead cancer patients to anemia, apart from therapy are iron deficiency, inflammatory cytokines surge and decreased erythropoietin (Epo). Our aim was to quantify biochemical and hematologic markers serum Epo, ferritin (Fe) and tumor necrosis factor-alpha (TNF-α) along with ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175579
更新日期:2015-01-01 00:00:00
abstract::The practice of radiation oncology requires stringent adherence to specific steps and principles designed to minimize exposure of an individual to unnecessary doses of radiation. The basic principles of such measures to reduce the risk of exposure and limit the doses of irradiation follow the "as low as reasonably ach...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_343_20
更新日期:2020-04-01 00:00:00
abstract::Secondary neoplasm of the thyroid mimicking a primary thyroid lesion is a rare finding, especially in an individual without a past history of malignancy. A case of squamous cell carcinoma metastatic to the thyroid (presenting as a solitary thyroid nodule), who had an unsuspected primary in the esophagus is described. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175569
更新日期:2015-01-01 00:00:00
abstract:Background:Gestational trophoblastic neoplasia (GTN) are a spectrum of tumors that develop from placental tissue. We aimed to evaluate the management and treatment outcome of GTN. Methods:Patients diagnosed with GTN presented to Kasr Alainy Center of Clinical Oncology between 2008 and 2017 were included in this study....
journal_title:Indian journal of cancer
pub_type: 杂志文章
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更新日期:2021-01-06 00:00:00
abstract::Lymphnode infarction is seen in two sets of situations viz. spontaneous banal infarction of non-neoplastic nodes, and in association with lymphoma. It needs to be differentiated from other causes of lymphnode as a phenomenon occurring synchronous with and occasionally preceding diagnosis of lymphoma is significant. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00