Myoepithelial expression of Fas and strong nuclear expression of FasL in epithelial cells: a marker for risk stratification of breast cancer.

Abstract:

AIM:The clinical significance of Fas and FasL in hormone-sensitive carcinomas has been reported. Our objective was to evaluate the expression of apoptosis-regulating genes Fas and FasL in Indian breast cancer and fibroadenoma patients in relation to hormone receptor status. STUDY DESIGN:Retrospective. MATERIALS AND METHODS:Paraffin-embedded tissue samples from 63 untreated female patients with invasive ductal carcinoma (IDC) and 32 female patients with fibroadenoma were studied. Expression of Fas and FasL was evaluated using immunohistochemical staining method. STATISTICAL ANALYSIS:Fisher's exact test and nonparametric correlation test (Spearman rank correlation test) were performed. RESULT:Fas was detected in 97% of the fibroadenomas and there was a slight decrease in levels of expression with histological grades of IDC. The expression of FasL was detected in 75% fibroadenomas and its expression increased in IDC. There was no correlation between Fas, FasL expression and hormone receptor status. Strong expression of Fas in myoepithelial cells was noted in 12 out of 32 fibroadenoma cases. CONCLUSION:Expression of Fas and FasL alone is unlikely to be important as a predictive factor as they express in both normal and malignant breast epithelium. But strong expression of Fas in myoepithelial cells along with strong nuclear expression of FasL in epithelial cells of fibroadenoma could be useful as an early predictive factor for onset of malignancy.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Ranade KJ,Nerurkar AV,Phulpagar MD,Shirsat NV

doi

10.4103/0019-509X.98921

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

60-5

issue

1

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2012_49_1_60_98921

journal_volume

49

pub_type

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