Abstract:
:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRAF (V600E) mutation was present in 15 (30 %) tumors. From genotype-histologic variant correlation perspective, 13 of 24 classic variant PTCs and 2 of 7 diffuse sclerosing variant PTCs were found to harbor BRAF (V600E) mutation. One cribriform-morular variant, 3 solid variant, and 15 follicular variant PTCs were BRAF wild type. While tumors with distant metastasis were BRAF wild type, two of five tumors with extrathyroidal extension (ETE) harbored BRAF (V600E) mutation. Nine of 15 BRAF (V600E) harboring tumors had central lymph node metastases. There was no significant correlation with BRAF (V600E) mutation and age, gender, tumor size, ETE, central lymph node metastasis, the status of pT, pN1a-b, and distant metastasis. An adverse correlation between BRAF (V600E) mutation and disease-free survival (DFS) was noted in the entire cohort; however, the predictive value of BRAF (V600E) mutation disappeared within the group of tumors displaying classic architecture as well as classic variant PTCs. The present cohort identifies that the classic architecture with multicentricity and local recurrence are correlates of BRAF (V600E) harboring pediatric PTCs. While the small size of this cohort is one of the limitations, neither the BRAF mutation status nor the classic tumor architecture does seem to be an independent prognosticator of DFS in this series. Evidence also suggests that TERT promoter mutations do not seem to play a major role in the pathogenesis of pediatric PTCs.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Onder S,Ozturk Sari S,Yegen G,Sormaz IC,Yilmaz I,Poyrazoglu S,Sanlı Y,Giles Senyurek Y,Kapran Y,Mete Odoi
10.1007/s12022-016-9420-0subject
Has Abstractpub_date
2016-06-01 00:00:00pages
153-61issue
2eissn
1046-3976issn
1559-0097pii
10.1007/s12022-016-9420-0journal_volume
27pub_type
杂志文章abstract::The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:13:4:321
更新日期:2002-01-01 00:00:00
abstract::An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:13:2:125
更新日期:2002-07-01 00:00:00
abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09650-1
更新日期:2021-01-04 00:00:00
abstract::Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:17:1:53
更新日期:2006-04-01 00:00:00
abstract::The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739915
更新日期:1996-04-01 00:00:00
abstract::In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739836
更新日期:1996-01-01 00:00:00
abstract::Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739931
更新日期:1997-01-01 00:00:00
abstract::Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9571-x
更新日期:2019-06-01 00:00:00
abstract::Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid ca...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-010-9129-4
更新日期:2010-12-01 00:00:00
abstract::Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. T...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738793
更新日期:1997-10-01 00:00:00
abstract::Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915325
更新日期:1991-03-01 00:00:00
abstract::Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cell...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915304
更新日期:1993-09-01 00:00:00
abstract::Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:17:3:235
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-003-0017-z
更新日期:2003-10-01 00:00:00
abstract::The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738728
更新日期:1995-01-01 00:00:00
abstract::Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739692
更新日期:1998-01-01 00:00:00
abstract::Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739972
更新日期:1996-07-01 00:00:00
abstract::Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medul...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:12:4:365
更新日期:2001-01-01 00:00:00
abstract::The adrenal gland is the body's primary source for epinephrine production and release, and the chromaffin cells that comprise the adrenal medulla possess all of the catecholamine biosynthetic machinery, including phenylethanolamine N-methyltransferase (PNMT), the enzyme synthesizing epinephrine from norepinephrine. In...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:1:25
更新日期:2003-04-01 00:00:00
abstract::The history of pituitary pathology is a long one that dates back to biblical times, but the last 25 years have represented an era of "coming of age." The role of the pituitary in health and disease was the subject of many studies over the last century. With the development of electron microscopy, immunoassays, and imm...
journal_title:Endocrine pathology
pub_type: 历史文章,杂志文章
doi:10.1007/s12022-013-9284-5
更新日期:2014-03-01 00:00:00
abstract::Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9087-x
更新日期:2009-01-01 00:00:00
abstract::Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9333-8
更新日期:2014-12-01 00:00:00
abstract::Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915391
更新日期:1990-09-01 00:00:00
abstract::The question of whether thyroxine (T(4)) and thyrotropin-releasing hormone (TRH) affect mitoses in pituitary thyrotrophs (Tt) and somatotrophs (St) of hypothyroid rats was investigated. Fifteen day thyroidectomized (Tx) rats were used. Groups of Tx animals received T(4) or TRH or both. Except 6 and 24 h TRH groups, th...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739776
更新日期:1999-01-01 00:00:00
abstract::Pediatric adrenocortical carcinoma is extremely rare with a prevalence of 0.3 per million. Adrenocortical neoplasms in children usually present with one of the endocrine abnormalities. Adrenocortical neoplasms cannot be easily diagnosed on cytopathology; hence, the cytomorphological features posing diagnostic dilemmas...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-010-9142-7
更新日期:2011-03-01 00:00:00
abstract::Understanding the molecular mechanisms involved in thyroid cancer progression may provide targets for more effective treatment of aggressive thyroid cancers. Epithelial mesenchymal transition (EMT) is a major pathologic mechanism in tumor progression and is linked to the acquisition of stem-like properties of cancer c...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9272-9
更新日期:2013-12-01 00:00:00
abstract::Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915452
更新日期:1991-09-01 00:00:00
abstract::Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739883
更新日期:1995-10-01 00:00:00
abstract::We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis. The patient was diagnosed with breast cancer and received chemotherapy 3 years before parathyroidectomy. The question can be raised whether chemotherapeutic agents may damage pa...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-0001-0
更新日期:2007-04-01 00:00:00
abstract::Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-9002-2
更新日期:2008-04-01 00:00:00