Abstract：
:Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth factors or cell-cycle proteins, we analyzed a series of papillary carcinomas including the conventional or usual type (n = 27), tall cell (n = 27), diffuse sclerosing (n = 5), and columnar cell (n = 2) variants for expression of transforming growth factor beta (TGB), TGB receptors (TGB-RI and II, the proliferation marker Ki-67, and for the cell-cycle inhibitory protein p27(Kip)1 (p27). All groups of thyroid tumors expressed TGFB and TGFB-RI and RlI by immunohistochemical staining. There was a marked increase in the Ki-67 labeling index after staining with antibody MIB-1 in the columnar cell tumors compared to the other groups, but this difference was not significant because of the small number of tumors in this group. The cell-cycle inhibitory protein p27 was expressed in all groups and was not significantly different between groups. Normal thyroid cells had a higher labeling index for p27 compared to papillary carcinomas. These results indicate that TGFB and TGFB receptors I and II are commonly expressed in the usual and in variant forms of papillary thyroid carcinomas, and that there is decreased expression of p27 protein in all of these neoplasms compared to normal thyroid. The biological basis for the more aggressive behavior of these variants of papillary thyroid carcinoma remains uncertain.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Lloyd RV,Ferreiro JA,Jin L,Sebo TJdoi
10.1007/BF02739931keywords:
subject
Has Abstractpub_date
1997-01-01 00:00:00pages
293-300issue
4eissn
1046-3976issn
1559-0097pii
EP0804293journal_volume
8pub_type
杂志文章abstract：:Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915325
更新日期：1991-03-01 00:00:00
abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:15:3:241
更新日期：2004-10-01 00:00:00
abstract：:Non-coding (nc)RNAs are divided into small ncRNAs and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are small ncRNAS which are around 22 nucleotides in length that mediate post-transcriptional gene silencing. LncRNAs are greater than 200 bp in length. Each ncRNA can have multiple targets and can be regulated by multiple g...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-016-9417-8
更新日期：2016-03-01 00:00:00
abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9466-z
更新日期：2017-03-01 00:00:00
abstract：:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739883
更新日期：1995-10-01 00:00:00
abstract：:Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9422-y
更新日期：2016-12-01 00:00:00
abstract：:Pleomorphic leiomyosarcoma (PLMS) of the adrenal gland is a rare tumor in an unusual location. A primary PLMS of the left adrenal gland is reported in a 59-yr-old Mexican woman who presented progressive flank pain and weight loss. The tumor measured 16 cm in diameter, showed markedly pleomorphic and osteoclast-like gi...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:16:1:075
更新日期：2005-04-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-011-9146-y
更新日期：2011-03-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-020-09630-5
更新日期：2020-09-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:12:4:365
更新日期：2001-01-01 00:00:00
abstract：:A 59-yr old female presented with Cushing's syndrome due to ectopic ACTH production. At the time of initial diagnosis an obvious source for the Cushing's syndrome was not found and the patient was treated with bilateral adrenalectomy. Three years later she presented with hyperpigmentation and evidence of ACTH overprod...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:16:2:145
更新日期：2005-07-01 00:00:00
abstract：:The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9577-4
更新日期：2019-06-01 00:00:00
abstract：:Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02914989
更新日期：1995-04-01 00:00:00
abstract：:Gain-of-function germline mutations of the RET proto-oncogene are responsible for initiation of carcinogenesis within the thyroid gland and development of hereditary form of medullary thyroid carcinoma and MEN2 syndrome. Genotype-phenotype correlations are established for most RET mutations, but the importance of the ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9487-2
更新日期：2017-09-01 00:00:00
abstract：:High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9516-9
更新日期：2018-09-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-007-9007-x
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:16:4:331
更新日期：2005-01-01 00:00:00
abstract：:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9420-0
更新日期：2016-06-01 00:00:00
abstract：:The BRAF(V600E) mutation is specific for thyroid papillary cancer (PTC) and correlates with PTCs invasiveness. This study investigated whether detection of BRAF(V600E) mutation can be performed on routinely stained FNABs. We also examined if establishment of the BRAF(V600E) mutation could help in identification of pat...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-011-9180-9
更新日期：2011-12-01 00:00:00
abstract：:In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739836
更新日期：1996-01-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9021-7
更新日期：2008-04-01 00:00:00
abstract：:Pheochromocytomas and paragangliomas are neuroendocrine neoplasias of neural crest origin. Genetic mutations that are characterized in other human neoplasms are rarely seen in these tumors. About 10% of the patients with pheochromocytomas and paragangliomas present with a family history of von Hippel-Lindau disease (V...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:4:329
更新日期：2003-01-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739776
更新日期：1999-01-01 00:00:00
abstract：:CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. The scope of the present study was to validate their role in PC patients and investigate potential application in clinical practice. Data was collected from patients presenting to...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9459-y
更新日期：2017-03-01 00:00:00
abstract：:The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less t...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9483-6
更新日期：2017-06-01 00:00:00
abstract：:Pediatric adrenocortical carcinoma is extremely rare with a prevalence of 0.3 per million. Adrenocortical neoplasms in children usually present with one of the endocrine abnormalities. Adrenocortical neoplasms cannot be easily diagnosed on cytopathology; hence, the cytomorphological features posing diagnostic dilemmas...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-010-9142-7
更新日期：2011-03-01 00:00:00
abstract：:We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be mor...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9575-6
更新日期：2019-06-01 00:00:00
abstract：:C cell hyperplasia is considered a precursor lesion for hereditary forms of medullary thyroid carcinoma. It has therefore been suggested as a morphological marker to distinguish hereditary from sporadic medullary thyroid carcinoma and to triage genetic testing in resource poor settings. However, numerous definitions f...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9567-6
更新日期：2019-06-01 00:00:00
abstract：:The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739950
更新日期：1998-04-01 00:00:00
abstract：:Synchronous occurrence of medullary and papillary carcinoma of the thyroid gland is very rare. We describe two cases of synchronous medullary and papillary carcinoma of the thyroid. In both cases, medullary carcinoma and papillary carcinoma were separate in the thyroid but mixed in some of the lymph node metastases. A...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:1:83
更新日期：2004-04-01 00:00:00
