Expression of MSX1 in human normal pituitaries and pituitary adenomas.

abstract：:Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...

journal_title：Endocrine pathology

authors： Harach HR,Bergholm U

更新日期：1993-03-01 00:00:00

abstract：:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...

journal_title：Endocrine pathology

authors： Onder S,Ozturk Sari S,Yegen G,Sormaz IC,Yilmaz I,Poyrazoglu S,Sanlı Y,Giles Senyurek Y,Kapran Y,Mete O

更新日期：2016-06-01 00:00:00

abstract：:Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...

journal_title：Endocrine pathology

authors： Rowe ME,Ozbek U,Machado RA,Yue LE,Hernandez-Prera JC,Valentino A,Qazi M,Brandwein-Weber M,Liu X,Wenig BM,Urken ML

更新日期：2018-03-01 00:00:00

abstract：:A cell fine of human medullary carcinoma of the thyroid, abundantly producing calcitonin (Ct) and related hormones, has proved remarkably useful as an endocrine tumor model for the study of the secretion mechanism. This cell line (TT cell) was used in studies to elucidate the dynamics of the release of Ct and chromogr...

journal_title：Endocrine pathology

authors： Kameya T,Kadoya K,Iguchi H,Abe Y,Shimaoka K

更新日期：1991-03-01 00:00:00

abstract：:The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...

journal_title：Endocrine pathology

authors： Girolami I,Pantanowitz L,Mete O,Brunelli M,Marletta S,Colato C,Trimboli P,Crescenzi A,Bongiovanni M,Barbareschi M,Eccher A

更新日期：2020-09-01 00:00:00

abstract：:High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...

journal_title：Endocrine pathology

authors： Gupta S,Sahu D,Bomalaski JS,Frank I,Boorjian SA,Thapa P,Cheville JC,Hansel DE

更新日期：2018-09-01 00:00:00

abstract：:We report a very rare case of Cushing's syndrome caused by an ileal adrenocorticotrophin-secreting well-differentiated endocrine carcinoma with liver metastases. A 62-yr-old woman presented with clinical and biological signs suggestive of paraneoplastic Cushing's syndrome Radiological investigations, including magneti...

journal_title：Endocrine pathology

authors： Valo I,Rohmer V,Guyetant S,Martin JF,Venault S,Saint-Andre JP

更新日期：2000-01-01 00:00:00

abstract：:Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...

journal_title：Endocrine pathology

authors： Saeger W,Saager G,Schubert B,Caselitz J

更新日期：1991-03-01 00:00:00

abstract：:A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneo...

journal_title：Endocrine pathology

authors： Lin J,Wasco MJ,Korobkin M,Doherty G,Giordano TJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...

journal_title：Endocrine pathology

authors： Thompson LD,Wieneke JA,Heffess CS

更新日期：2005-01-01 00:00:00

abstract：:The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...

journal_title：Endocrine pathology

authors： Hunt JL,Baloch ZW,Barnes L,Swalsky PA,Trusky CL,Sesatomi E,Finkelstein S,LiVolsi VA

更新日期：2002-01-01 00:00:00

abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...

journal_title：Endocrine pathology

authors： Carr R,Ustun B,Chhieng D,Schofield K,Theoharis C,Hammers L,Adeniran AJ

更新日期：2013-06-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...

journal_title：Endocrine pathology

authors： Yokoyama S,Stefaneanu L,Kovacs K

更新日期：1997-10-01 00:00:00

abstract：:The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...

journal_title：Endocrine pathology

authors： Lloyd RV,Schroeder G,Bauman MD,Krook JE,Jin L,Goldberg RM,Farr GH Jr

更新日期：1998-04-01 00:00:00

abstract：:The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. We report the clinical history and the laboratory, imaging, and histopathological findings of a 47-year-old man affecte...

journal_title：Endocrine pathology

authors： Fibbi B,Pinzani P,Salvianti F,Rossi M,Petrone L,De Feo ML,Panconesi R,Vezzosi V,Bianchi S,Simontacchi G,Mangoni M,Pertici M,Forti G,Pupilli C

更新日期：2014-09-01 00:00:00

abstract：:Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...

journal_title：Endocrine pathology

authors： Zheng Z,Zhou X,Cai Y,Chen E,Zhang X,Wang O,Wang Q,Liu H

更新日期：2018-12-01 00:00:00

abstract：:The recent increase in the detection of papillary thyroid carcinoma (PTC) has been influenced by the finding of incidental tumours. To this group, carcinomas measuring less than 1 cm (the so-called microcarcinomas) as well as those above 1 cm belong. Analyzing a case series from our own experience, this paper focuses ...

journal_title：Endocrine pathology

authors： Pagni F,Jaconi M,Delitala A,Garancini M,Maternini M,Bono F,Giani A,Smith A,San Gerardo Hospital collaborators group.

更新日期：2014-09-01 00:00:00

abstract：:Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...

journal_title：Endocrine pathology

authors： Jug R,Parajuli S,Ahmadi S,Jiang XS

更新日期：2019-06-01 00:00:00

abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...

journal_title：Endocrine pathology

authors： Gucer H,Bagci P,Bedir R,Sehitoglu I,Mete O

更新日期：2016-09-01 00:00:00

abstract：:There is evidence that programmed death-ligand 1 (PD-L1) is expressed by thyroid follicular epithelium in thyroiditis, but the role of PD-L1 in papillary thyroid carcinoma (PTC) is poorly understood. We aimed to determine whether (1) the presence of background chronic lymphocytic thyroiditis (CLT) or Hashimoto thyroid...

journal_title：Endocrine pathology

authors： Lubin D,Baraban E,Lisby A,Jalali-Farahani S,Zhang P,Livolsi V

更新日期：2018-12-01 00:00:00

abstract：:A case of ectopic thymic tissue of the thyroid in a 30-year-old woman with Graves' disease is reported. The thyroidectomy specimen, removed because of failure of medical therapy, showed a continuous track of thymic tissue extending from the center of the gland to the capsule along an interiobular septum. This finding ...

journal_title：Endocrine pathology

authors： Mizukami Y,Nanomura A,Michigishi T,Noguchi N,Nakamura S

更新日期：1993-09-01 00:00:00

abstract：:The pituitary contains estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR). In accordance with immunocytochemistry, it is agreed that sex hormone receptors reside into the nucleus. All three receptors are found predominantly in gonadotrophs and lactotrophs, and less frequently in other cell ...

journal_title：Endocrine pathology

authors： Stefaneanu L

更新日期：1997-07-01 00:00:00

abstract：:Hurthle cell carcinoma of the thyroid is generally considered to be a subtype of follicular carcinoma. We report a case of a small solitary usual-type papillary carcinoma of the thyroid, with metastatic tumor in cervical lymph nodes. The lymph node tumor consisted of both tall-cell papillary carcinoma and Hurthle cell...

journal_title：Endocrine pathology

authors： Zwi LJ,LiVolsi VA

更新日期：2002-10-01 00:00:00

abstract：:The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...

journal_title：Endocrine pathology

authors： Wong KS,Strickland KC,Angell TE,Nehs MA,Alexander EK,Cibas ES,Krane JF,Howitt BE,Barletta JA

更新日期：2017-06-01 00:00:00

abstract：:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...

journal_title：Endocrine pathology

authors： Righi A,Zhang S,Jin L,Scheithauer BW,Kovacs K,Kovacs G,Goth MI,Korbonits M,Lloyd RV

更新日期：2010-03-01 00:00:00

abstract：:Using conventional histological technique, we investigated 44 adenomas (31 men, 13 women) incidentally found in 36 pituitaries (25 men, 11 women) obtained from 1,117 unselected autopsies. The overall incidence of adenomas was 3.2% (men, 3.8%; women, 2.4%) without any significant sex predominance. Size, age distributio...

journal_title：Endocrine pathology

authors： Uei Y,Kanzaki M,Yabana T

更新日期：1994-06-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...

journal_title：Endocrine pathology

authors： Roy M,Buehler DG,Zhang R,Schwalbe ML,Baus RM,Salamat MS,Lloyd RV,Rosenbaum JN

更新日期：2019-03-01 00:00:00

abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...

journal_title：Endocrine pathology

authors： Abbona G,Papotti M,Gasparri G,Bussolati G

更新日期：1996-04-01 00:00:00

abstract：:Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on ...

journal_title：Endocrine pathology

authors： Cameselle-Teijeiro JM,Eloy C,Sobrinho-Simões M

更新日期：2020-09-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00