Fatal sporadic medullary carcinoma of the thyroid.

abstract：:Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...

journal_title：Endocrine pathology

authors： Lloyd RV,Ferreiro JA,Jin L,Sebo TJ

更新日期：1997-01-01 00:00:00

abstract：:Synchronous occurrence of medullary and papillary carcinoma of the thyroid gland is very rare. We describe two cases of synchronous medullary and papillary carcinoma of the thyroid. In both cases, medullary carcinoma and papillary carcinoma were separate in the thyroid but mixed in some of the lymph node metastases. A...

journal_title：Endocrine pathology

authors： Seki T,Kameyama K,Hayashi H,Nagahama M,Masudo K,Fukunari N,Tanaka K,Sugino K,Ito K,Takami H

更新日期：2004-04-01 00:00:00

abstract：:Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...

journal_title：Endocrine pathology

authors： Sargent R,LiVolsi V,Murphy J,Mantha G,Hunt JL

更新日期：2006-10-01 00:00:00

abstract：:Metallothionein-3 (MT-3) is an intracellular, low molecular weight protein mainly distributed in the central nervous system but also in various peripheral organs and several types of human neoplasms. However, details of MT-3 expression have not been examined in human adrenal cortex and its disorders. The mRNA levels o...

journal_title：Endocrine pathology

authors： Felizola SJ,Nakamura Y,Arata Y,Ise K,Satoh F,Rainey WE,Midorikawa S,Suzuki S,Sasano H

更新日期：2014-09-01 00:00:00

abstract：:Pleomorphic leiomyosarcoma (PLMS) of the adrenal gland is a rare tumor in an unusual location. A primary PLMS of the left adrenal gland is reported in a 59-yr-old Mexican woman who presented progressive flank pain and weight loss. The tumor measured 16 cm in diameter, showed markedly pleomorphic and osteoclast-like gi...

journal_title：Endocrine pathology

authors： Candanedo-González FA,Vela Chávez T,Cérbulo-Vázquez A

更新日期：2005-04-01 00:00:00

abstract：:Pediatric adrenocortical carcinoma is extremely rare with a prevalence of 0.3 per million. Adrenocortical neoplasms in children usually present with one of the endocrine abnormalities. Adrenocortical neoplasms cannot be easily diagnosed on cytopathology; hence, the cytomorphological features posing diagnostic dilemmas...

journal_title：Endocrine pathology

authors： Agarwal S,Agarwal K

更新日期：2011-03-01 00:00:00

abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...

journal_title：Endocrine pathology

authors： Carr R,Ustun B,Chhieng D,Schofield K,Theoharis C,Hammers L,Adeniran AJ

更新日期：2013-06-01 00:00:00

abstract：:Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...

journal_title：Endocrine pathology

authors： Pilichowska M,Kimura N,Schindler M,Kobari M

更新日期：2001-07-01 00:00:00

abstract：:Approximately 90% of neoplasms found in the sellar region are adenoma of the pituitary gland. The use of frozen sections for the diagnosis of pituitary adenomas has an accuracy of 90% and is useful in evaluating complete tumor removal. However, it is sometimes difficult to diagnose pituitary adenomas using frozen sect...

journal_title：Endocrine pathology

authors： Noh S,Kim SH,Cho NH,Kim SH

更新日期：2015-05-01 00:00:00

abstract：:Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...

journal_title：Endocrine pathology

authors： Duan K,Asa SL,Winer D,Gelareh Z,Gentili F,Mete O

更新日期：2017-03-01 00:00:00

abstract：:Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin- and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report the first case of an association between craniopharyngioma ...

journal_title：Endocrine pathology

authors： Moshkin O,Scheithauer BW,Syro LV,Velasquez A,Horvath E,Kovacs K

更新日期：2009-04-01 00:00:00

abstract：:Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...

journal_title：Endocrine pathology

authors： Rowe ME,Ozbek U,Machado RA,Yue LE,Hernandez-Prera JC,Valentino A,Qazi M,Brandwein-Weber M,Liu X,Wenig BM,Urken ML

更新日期：2018-03-01 00:00:00

abstract：:Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...

journal_title：Endocrine pathology

authors： Stilling GA,Bayliss JM,Jin L,Zhang H,Lloyd RV

更新日期：2005-10-01 00:00:00

abstract：:A case of ectopic thymic tissue of the thyroid in a 30-year-old woman with Graves' disease is reported. The thyroidectomy specimen, removed because of failure of medical therapy, showed a continuous track of thymic tissue extending from the center of the gland to the capsule along an interiobular septum. This finding ...

journal_title：Endocrine pathology

authors： Mizukami Y,Nanomura A,Michigishi T,Noguchi N,Nakamura S

更新日期：1993-09-01 00:00:00

abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...

journal_title：Endocrine pathology

authors： Gucer H,Bagci P,Bedir R,Sehitoglu I,Mete O

更新日期：2016-09-01 00:00:00

abstract：:There is evidence that programmed death-ligand 1 (PD-L1) is expressed by thyroid follicular epithelium in thyroiditis, but the role of PD-L1 in papillary thyroid carcinoma (PTC) is poorly understood. We aimed to determine whether (1) the presence of background chronic lymphocytic thyroiditis (CLT) or Hashimoto thyroid...

journal_title：Endocrine pathology

authors： Lubin D,Baraban E,Lisby A,Jalali-Farahani S,Zhang P,Livolsi V

更新日期：2018-12-01 00:00:00

abstract：:Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8...

journal_title：Endocrine pathology

authors： Beckers A,Kovacs K,Horvath E,Abs R,Reznik M,Stevenaert A

更新日期：1991-09-01 00:00:00

abstract：:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...

journal_title：Endocrine pathology

authors： Righi A,Zhang S,Jin L,Scheithauer BW,Kovacs K,Kovacs G,Goth MI,Korbonits M,Lloyd RV

更新日期：2010-03-01 00:00:00

abstract：:In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...

journal_title：Endocrine pathology

authors： Lee SH,Baek JS,Lee JY,Lim JA,Cho SY,Lee TH,Ku YH,Kim HI,Kim MJ

更新日期：2013-12-01 00:00:00

abstract：:The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...

journal_title：Endocrine pathology

authors： Lloyd RV,Schroeder G,Bauman MD,Krook JE,Jin L,Goldberg RM,Farr GH Jr

更新日期：1998-04-01 00:00:00

abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...

journal_title：Endocrine pathology

authors： Rego KG,Billerbeck AE,Targovnik HM,Santos CL,Alkmin MG,Barbosa S,Camargo R,Medeiros-Neto G

更新日期：1997-04-01 00:00:00

abstract：:The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...

journal_title：Endocrine pathology

authors： Suzuki M,Egashira N,Kajiya H,Minematsu T,Takekoshi S,Tahara S,Sanno N,Teramoto A,Osamura RY

更新日期：2008-04-01 00:00:00

abstract：:Goblet cell carcinoid (GCC) of the appendix is a rare entity, of which both the histogenesis and biologic behavior remain controversial, and prognostic tools and therapeutic strategies for this unusual tumor have yet to be defined. The aim of this study was to analyze expression of E-cadherin and b-catenin in GCCs of ...

journal_title：Endocrine pathology

authors： Li CC,Hirowaka M,Qian ZR,Xu B,Sano T

更新日期：2002-04-01 00:00:00

abstract：:Recent advances in molecular pathology have shed light not only on the cellular composition and derivation of various tumors, but also on their growth potential, likelihood of recurrence, and prognosis. The development of reliable and prognostically informative methods of assessing tumor behavior is particularly impor...

journal_title：Endocrine pathology

authors： Suhardja A,Kovacs K,Greenberg O,Scheithauer BW,Lloyd RV

更新日期：2005-04-01 00:00:00

abstract：:Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...

journal_title：Endocrine pathology

authors： Lubensky IA,Zhuang Z

更新日期：2007-10-01 00:00:00

abstract：:Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...

journal_title：Endocrine pathology

authors： Salgado LR,Mendonca BB,Goldman J,Semer M,Knoepfelmacher M,Tsanaclis AM,Wajchenberg BL,Liberman B

更新日期：1995-04-01 00:00:00

abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...

journal_title：Endocrine pathology

authors： Nosé V,Volante M,Papotti M

更新日期：2008-04-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00

abstract：:Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...

journal_title：Endocrine pathology

authors： Kasem K,Lam AK

更新日期：2014-12-01 00:00:00

abstract：:We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...

journal_title：Endocrine pathology

authors： Rotondo F,Qaddoura A,Syro LV,Karamchandani J,Munoz DG,Arroyave MJ,Ospina WP,Cusimano MD,Kovacs K

更新日期：2017-12-01 00:00:00