Abstract:
:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear features and RET/PTC1 translocations of papillary thyroid carcinoma. These tumors are not associated with RAS or BRAF mutations. Whether the presence of RET alterations in HTT are sufficient molecular proof of its relationship with papillary thyroid carcinoma (PTC) is still to be defined. Of great interest is the characteristic strong peripheral cytoplasmic and membranous staining of the tumor cells with MIB1 immunostain, not seen in any other thyroid neoplasm. Although cases of malignant HTT have been recorded, HTT should be considered a benign neoplasm or, at most, a neoplasm of extremely low malignant potential.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Nosé V,Volante M,Papotti Mdoi
10.1007/s12022-007-9002-2subject
Has Abstractpub_date
2008-04-01 00:00:00pages
1-8issue
1eissn
1046-3976issn
1559-0097journal_volume
19pub_type
杂志文章abstract::Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. T...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738793
更新日期:1997-10-01 00:00:00
abstract::A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneo...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9013-7
更新日期:2007-01-01 00:00:00
abstract::Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-017-9471-x
更新日期:2017-03-01 00:00:00
abstract::The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915332
更新日期:1991-06-01 00:00:00
abstract::Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:15:4:351
更新日期:2004-01-01 00:00:00
abstract::Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:17:3:235
更新日期:2006-10-01 00:00:00
abstract::We report clinicopathological features of a large series of synchronous multiple pituitary neuroendocrine tumors (PitNETs) of different cell lineages. Retrospective review of pathology records from 2001 to 2016 identified 13 synchronous multiple PitNETs from 1055 PitNETs classified using pituitary cell-lineage transcr...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9545-4
更新日期:2018-12-01 00:00:00
abstract::Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on ...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-020-09638-x
更新日期:2020-09-01 00:00:00
abstract::Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09612-7
更新日期:2020-06-01 00:00:00
abstract::A case of pancreatic acinar cell tumor (ACC) is presented in a 10-year-old boy. The tumor manifested clinically with Cushing's syndrome, high serum adrenocorticotropic hormone (ACTH) and cortisol concentrations. In addition, excessive serum levels of alpha-fetoprotein (AFP) were detected. Surgical resection was not po...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-0018-4
更新日期:2007-07-01 00:00:00
abstract::Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:15:3:241
更新日期:2004-10-01 00:00:00
abstract::Hashimoto's thyroiditis is the archetype of organ-specific autoimmune disease. The key pathogenetic feature is the activation of thyroid-specific T-cells by properly presented endogenous thyroid antigens. There is strong indication that thyrocytes themselves present self-antigens, based on the finding of antigen prese...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739959
更新日期:1998-10-01 00:00:00
abstract::Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In add...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-008-9054-y
更新日期:2009-04-01 00:00:00
abstract::Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02914490
更新日期:1993-03-01 00:00:00
abstract::Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9087-x
更新日期:2009-01-01 00:00:00
abstract::Breast carcinomas often metastasize into various organs, most commonly into the lung and rather infrequently into the pineal gland. There were only 20 cases of the latter recorded until 1950. Currently, the total number of reported cases, including this report, is 74. At Sunnybrook Health Science Centre, between 1984 ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921371
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:4:331
更新日期:2005-01-01 00:00:00
abstract::The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09630-5
更新日期:2020-09-01 00:00:00
abstract::Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915391
更新日期:1990-09-01 00:00:00
abstract::The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738728
更新日期:1995-01-01 00:00:00
abstract::High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9516-9
更新日期:2018-09-01 00:00:00
abstract::Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9559-y
更新日期:2019-03-01 00:00:00
abstract::Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recent...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9557-0
更新日期:2019-03-01 00:00:00
abstract::Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9096-9
更新日期:2010-03-01 00:00:00
abstract::The history of pituitary pathology is a long one that dates back to biblical times, but the last 25 years have represented an era of "coming of age." The role of the pituitary in health and disease was the subject of many studies over the last century. With the development of electron microscopy, immunoassays, and imm...
journal_title:Endocrine pathology
pub_type: 历史文章,杂志文章
doi:10.1007/s12022-013-9284-5
更新日期:2014-03-01 00:00:00
abstract::An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:13:2:125
更新日期:2002-07-01 00:00:00
abstract::We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9464-1
更新日期:2017-12-01 00:00:00
abstract::In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9263-x
更新日期:2013-12-01 00:00:00
abstract::Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739931
更新日期:1997-01-01 00:00:00
abstract::Pleomorphic leiomyosarcoma (PLMS) of the adrenal gland is a rare tumor in an unusual location. A primary PLMS of the left adrenal gland is reported in a 59-yr-old Mexican woman who presented progressive flank pain and weight loss. The tumor measured 16 cm in diameter, showed markedly pleomorphic and osteoclast-like gi...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:1:075
更新日期:2005-04-01 00:00:00