Abstract：
:The history of pituitary pathology is a long one that dates back to biblical times, but the last 25 years have represented an era of "coming of age." The role of the pituitary in health and disease was the subject of many studies over the last century. With the development of electron microscopy, immunoassays, and immunohistochemistry, the functional alterations associated with pituitary disease have been clarified. The additional information provided by molecular genetic studies has allowed progress in understanding the pathogenesis of pituitary disorders. Nevertheless, many questions remain to be answered. For example, pathologists cannot morphologically distinguish locally aggressive adenomas from carcinomas when tumor is confined to the sella. Sadly, basal cell carcinoma, the most common carcinoma of skin, usually causes less morbidity than pituitary adenomas, which occur in almost 20 % of the general population, can cause significant illness and even death, and yet are still classified as benign. The opportunity to increase awareness of the impact of these common lesions on quality of life is the current challenge for physicians and patients. We anticipate that ongoing multidisciplinary approaches to pituitary disease research will offer new insights into diseases arising from this fascinating organ.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Asa SL,Mete Odoi
10.1007/s12022-013-9284-5subject
Has Abstractpub_date
2014-03-01 00:00:00pages
6-11issue
1eissn
1046-3976issn
1559-0097journal_volume
25pub_type
历史文章,杂志文章abstract：:Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human br...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:11:1:57
更新日期：2000-04-01 00:00:00
abstract：:The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739950
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-003-0017-z
更新日期：2003-10-01 00:00:00
abstract：:Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In add...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-008-9054-y
更新日期：2009-04-01 00:00:00
abstract：:Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:17:1:53
更新日期：2006-04-01 00:00:00
abstract：:The cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity that is associated with familial adenomatous polyposis (FAP). We report a case of a young lady with an incidentally discovered right-sided neck nodule on ultrasonography with a diagnosis of CMV-PTC confirmed on thyroid...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-013-9274-7
更新日期：2014-09-01 00:00:00
abstract：:There is evidence that programmed death-ligand 1 (PD-L1) is expressed by thyroid follicular epithelium in thyroiditis, but the role of PD-L1 in papillary thyroid carcinoma (PTC) is poorly understood. We aimed to determine whether (1) the presence of background chronic lymphocytic thyroiditis (CLT) or Hashimoto thyroid...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9540-9
更新日期：2018-12-01 00:00:00
abstract：:Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9422-y
更新日期：2016-12-01 00:00:00
abstract：:Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cell...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915304
更新日期：1993-09-01 00:00:00
abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-013-9240-4
更新日期：2013-06-01 00:00:00
abstract：:Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739931
更新日期：1997-01-01 00:00:00
abstract：:Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739692
更新日期：1998-01-01 00:00:00
abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739706
更新日期：1997-04-01 00:00:00
abstract：:The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9476-5
更新日期：2017-06-01 00:00:00
abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-007-9002-2
更新日期：2008-04-01 00:00:00
abstract：:Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02914490
更新日期：1993-03-01 00:00:00
abstract：:In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739836
更新日期：1996-01-01 00:00:00
abstract：:Non-coding (nc)RNAs are divided into small ncRNAs and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are small ncRNAS which are around 22 nucleotides in length that mediate post-transcriptional gene silencing. LncRNAs are greater than 200 bp in length. Each ncRNA can have multiple targets and can be regulated by multiple g...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-016-9417-8
更新日期：2016-03-01 00:00:00
abstract：:The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915332
更新日期：1991-06-01 00:00:00
abstract：:Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. Th...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-009-9079-x
更新日期：2009-10-01 00:00:00
abstract：:Hashimoto's thyroiditis is the archetype of organ-specific autoimmune disease. The key pathogenetic feature is the activation of thyroid-specific T-cells by properly presented endogenous thyroid antigens. There is strong indication that thyrocytes themselves present self-antigens, based on the finding of antigen prese...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739959
更新日期：1998-10-01 00:00:00
abstract：:The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. We report the clinical history and the laboratory, imaging, and histopathological findings of a 47-year-old man affecte...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-014-9303-1
更新日期：2014-09-01 00:00:00
abstract：:To assess the proliferative activity of pituitary adenomas, 36 surgically removed adenomas were studied by light microscopical parameters; mitotic count; expression of PCNA, Ki-67, cathepsin D, and EGF; and image cytometry. Three adenomas (9%) showed high, 11 (34%) medium, 17 (53%) moderate, and 1 (3%) low structural ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02921487
更新日期：1994-12-01 00:00:00
abstract：:Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02914989
更新日期：1995-04-01 00:00:00
abstract：:Alterations of the von Hippel-Lindau (VHL) gene, which is supposed to act as a tumor suppressor gene, can cause hereditary tumors associated with the VHL syndrome and are found in different sporadic cancers as well. While VHL protein is distinctly detectable in thyroid follicles, so far its expression in nonneoplastic...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:11:2:145
更新日期：2000-07-01 00:00:00
abstract：:Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:2:107
更新日期：2003-07-01 00:00:00
abstract：:The BRAF(V600E) mutation is specific for thyroid papillary cancer (PTC) and correlates with PTCs invasiveness. This study investigated whether detection of BRAF(V600E) mutation can be performed on routinely stained FNABs. We also examined if establishment of the BRAF(V600E) mutation could help in identification of pat...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-011-9180-9
更新日期：2011-12-01 00:00:00
abstract：:Breast carcinomas often metastasize into various organs, most commonly into the lung and rather infrequently into the pineal gland. There were only 20 cases of the latter recorded until 1950. Currently, the total number of reported cases, including this report, is 74. At Sunnybrook Health Science Centre, between 1984 ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02921371
更新日期：1994-03-01 00:00:00
abstract：:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739883
更新日期：1995-10-01 00:00:00
abstract：:The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-015-9401-8
更新日期：2015-12-01 00:00:00
