Abstract:
:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues collected from 21 PCs, 4 follicular adenomas (FAs), 4 follicular carcinomas (FCs), and 11 nodular hyperplasias (NHs) were stained immunohistochemically for HlLA-D antigens, lymphocyte, and macrophage markers; results were graded numerically. Paraffin-embedded tumors (35 PCs, 10 FAs, and 10 FCs) were stained for 5-100 protein to detect Langerhans' cells (LCs). Diffuse staining for HLA-D antigens and heavy mononuclear infiltrates were found more commonly in PCs compared to follicular neoplasms (FNs) or NHs. No consistent relationship was found between lymphocyte/macrophage infiltrates and expression of HLA-D antigens. The largest number of LCs was in PCs (median 11.8 cells/standard microscopic field [c/smf]), fewer cells were found in FA (3.7 c/smf), and the least in FC (0.05 c/smf). Features of host-tumor interaction including HLA-D expression and infiltrates with lymphocyte macrophages and LC are more strongly expressed in PC than other tumors. This may play a role in explaining their biological behavior.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Raphael SL,Asa SLdoi
10.1007/BF02739883keywords:
subject
Has Abstractpub_date
1995-10-01 00:00:00pages
197-206issue
3eissn
1046-3976issn
1559-0097pii
EP0603197journal_volume
6pub_type
杂志文章abstract::Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:2:107
更新日期:2003-07-01 00:00:00
abstract::Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738783
更新日期:1997-10-01 00:00:00
abstract::The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738728
更新日期:1995-01-01 00:00:00
abstract::Breast carcinomas often metastasize into various organs, most commonly into the lung and rather infrequently into the pineal gland. There were only 20 cases of the latter recorded until 1950. Currently, the total number of reported cases, including this report, is 74. At Sunnybrook Health Science Centre, between 1984 ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921371
更新日期:1994-03-01 00:00:00
abstract::Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-9002-2
更新日期:2008-04-01 00:00:00
abstract::Hurthle cell carcinoma of the thyroid is generally considered to be a subtype of follicular carcinoma. We report a case of a small solitary usual-type papillary carcinoma of the thyroid, with metastatic tumor in cervical lymph nodes. The lymph node tumor consisted of both tall-cell papillary carcinoma and Hurthle cell...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-002-0002-y
更新日期:2002-10-01 00:00:00
abstract::Understanding the molecular mechanisms involved in thyroid cancer progression may provide targets for more effective treatment of aggressive thyroid cancers. Epithelial mesenchymal transition (EMT) is a major pathologic mechanism in tumor progression and is linked to the acquisition of stem-like properties of cancer c...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9272-9
更新日期:2013-12-01 00:00:00
abstract::An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:13:2:125
更新日期:2002-07-01 00:00:00
abstract::A case of ectopic thymic tissue of the thyroid in a 30-year-old woman with Graves' disease is reported. The thyroidectomy specimen, removed because of failure of medical therapy, showed a continuous track of thymic tissue extending from the center of the gland to the capsule along an interiobular septum. This finding ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915305
更新日期:1993-09-01 00:00:00
abstract::Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on ...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-020-09638-x
更新日期:2020-09-01 00:00:00
abstract::Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09612-7
更新日期:2020-06-01 00:00:00
abstract::The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:13:4:321
更新日期:2002-01-01 00:00:00
abstract::A cell fine of human medullary carcinoma of the thyroid, abundantly producing calcitonin (Ct) and related hormones, has proved remarkably useful as an endocrine tumor model for the study of the secretion mechanism. This cell line (TT cell) was used in studies to elucidate the dynamics of the release of Ct and chromogr...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915322
更新日期:1991-03-01 00:00:00
abstract::Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:15:3:241
更新日期:2004-10-01 00:00:00
abstract::Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medul...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:12:4:365
更新日期:2001-01-01 00:00:00
abstract::Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9466-z
更新日期:2017-03-01 00:00:00
abstract::Pleomorphic leiomyosarcoma (PLMS) of the adrenal gland is a rare tumor in an unusual location. A primary PLMS of the left adrenal gland is reported in a 59-yr-old Mexican woman who presented progressive flank pain and weight loss. The tumor measured 16 cm in diameter, showed markedly pleomorphic and osteoclast-like gi...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:1:075
更新日期:2005-04-01 00:00:00
abstract::Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9240-4
更新日期:2013-06-01 00:00:00
abstract::Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:15:4:351
更新日期:2004-01-01 00:00:00
abstract::Crohn's disease is one of the causes of secondary amyloidosis, which can lead to amyloid infiltration of the thyroid gland. It is essential to follow strict controls to prevent the appearance of a large amyloid goiter. Two patients with amyloid goiter secondary to Crohn's disease, with a large adipose tissue component...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-012-9220-0
更新日期:2012-12-01 00:00:00
abstract::We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9464-1
更新日期:2017-12-01 00:00:00
abstract::Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human br...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:11:1:57
更新日期:2000-04-01 00:00:00
abstract::Transcription factors play specific roles in the development and differentiation of normal pituitary tissues and pituitary adenoma. The transcription factor, muscle segment homeobox 1 (MSX1), which belongs to the homeobox gene family, binds the promoter region of the glycoprotein hormone alpha-subunit (SU) in TSH-prod...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9021-7
更新日期:2008-04-01 00:00:00
abstract::The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-017-9476-5
更新日期:2017-06-01 00:00:00
abstract::CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. The scope of the present study was to validate their role in PC patients and investigate potential application in clinical practice. Data was collected from patients presenting to...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9459-y
更新日期:2017-03-01 00:00:00
abstract::The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09630-5
更新日期:2020-09-01 00:00:00
abstract::Synchronous occurrence of medullary and papillary carcinoma of the thyroid gland is very rare. We describe two cases of synchronous medullary and papillary carcinoma of the thyroid. In both cases, medullary carcinoma and papillary carcinoma were separate in the thyroid but mixed in some of the lymph node metastases. A...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:15:1:83
更新日期:2004-04-01 00:00:00
abstract::Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739931
更新日期:1997-01-01 00:00:00
abstract::Metallothionein-3 (MT-3) is an intracellular, low molecular weight protein mainly distributed in the central nervous system but also in various peripheral organs and several types of human neoplasms. However, details of MT-3 expression have not been examined in human adrenal cortex and its disorders. The mRNA levels o...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9280-9
更新日期:2014-09-01 00:00:00
abstract::Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9455-2
更新日期:2016-12-01 00:00:00