Hurthle cell carcinoma arising from thyroid papillary carcinoma.

abstract：:Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...

journal_title：Endocrine pathology

authors： Fraune C,Simon R,Hube-Magg C,Makrypidi-Fraune G,Kluth M,Büscheck F,Amin T,Viol F,Fehrle W,Dum D,Höflmayer D,Burandt E,Clauditz TS,Perez D,Izbicki J,Wilczak W,Sauter G,Steurer S,Schrader J

更新日期：2020-06-01 00:00:00

abstract：:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...

journal_title：Endocrine pathology

authors： Righi A,Zhang S,Jin L,Scheithauer BW,Kovacs K,Kovacs G,Goth MI,Korbonits M,Lloyd RV

更新日期：2010-03-01 00:00:00

abstract：:Nonradioisotopic electron microscopic (EM) in situ hybridization (ISH) (EM-SH) with biotinylated oligonucleotide probes is utilized for the ultrastructural visualization of pituitary hormone mRNA in rat pituitary cells. EMISH is an important tool for clarifying the intracellular localization of mRNA and the exact site...

journal_title：Endocrine pathology

authors： Matsuno A,Itoh J,Osamura RY,Watanabe K,Nagashima T

更新日期：1999-10-01 00:00:00

abstract：:The question of whether thyroxine (T(4)) and thyrotropin-releasing hormone (TRH) affect mitoses in pituitary thyrotrophs (Tt) and somatotrophs (St) of hypothyroid rats was investigated. Fifteen day thyroidectomized (Tx) rats were used. Groups of Tx animals received T(4) or TRH or both. Except 6 and 24 h TRH groups, th...

journal_title：Endocrine pathology

authors： Quintanar-Stephano A,Valverde-R C,Kovacs K

更新日期：1999-01-01 00:00:00

abstract：:Recent advances in molecular pathology have shed light not only on the cellular composition and derivation of various tumors, but also on their growth potential, likelihood of recurrence, and prognosis. The development of reliable and prognostically informative methods of assessing tumor behavior is particularly impor...

journal_title：Endocrine pathology

authors： Suhardja A,Kovacs K,Greenberg O,Scheithauer BW,Lloyd RV

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...

journal_title：Endocrine pathology

authors： Thompson LD,Wieneke JA,Heffess CS

更新日期：2005-01-01 00:00:00

abstract：:A case of ectopic thymic tissue of the thyroid in a 30-year-old woman with Graves' disease is reported. The thyroidectomy specimen, removed because of failure of medical therapy, showed a continuous track of thymic tissue extending from the center of the gland to the capsule along an interiobular septum. This finding ...

journal_title：Endocrine pathology

authors： Mizukami Y,Nanomura A,Michigishi T,Noguchi N,Nakamura S

更新日期：1993-09-01 00:00:00

abstract：:Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...

journal_title：Endocrine pathology

authors： Pilichowska M,Kimura N,Schindler M,Kobari M

更新日期：2001-07-01 00:00:00

abstract：:We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...

journal_title：Endocrine pathology

authors： Rotondo F,Qaddoura A,Syro LV,Karamchandani J,Munoz DG,Arroyave MJ,Ospina WP,Cusimano MD,Kovacs K

更新日期：2017-12-01 00:00:00

abstract：:Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...

journal_title：Endocrine pathology

authors： Powers JF,Tsokas P,Tischler AS

更新日期：1998-01-01 00:00:00

abstract：:In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...

journal_title：Endocrine pathology

authors： Lee SH,Baek JS,Lee JY,Lim JA,Cho SY,Lee TH,Ku YH,Kim HI,Kim MJ

更新日期：2013-12-01 00:00:00

abstract：:Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. Th...

journal_title：Endocrine pathology

authors： Slosar M,Vohra P,Prasad M,Fischer A,Quinlan R,Khan A

更新日期：2009-10-01 00:00:00

abstract：:Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...

journal_title：Endocrine pathology

authors： Ghigna MR,Dorfmuller P,Crutu A,Fadel E,de Montpréville VT

更新日期：2016-12-01 00:00:00

abstract：:Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medul...

journal_title：Endocrine pathology

authors： Albores-Saavedra JA,Krueger JE

更新日期：2001-01-01 00:00:00

abstract：:An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells...

journal_title：Endocrine pathology

authors： Sano T,Kovacs K,Asa SL,Yamada S,Sanno N,Yokoyama S,Takami H

更新日期：2002-07-01 00:00:00

abstract：:Objective. Information on angiogenesis in parathyroid pathology is scanty and in particular no data are available in parathyroid carcinomas. The aim of this study was to analyze angiogenesis as microvascular density (MVD) in parathyroid neoplastic progression from normal gland to adenoma and carcinoma. Methods. Sectio...

journal_title：Endocrine pathology

authors： Viacava P,Bocci G,Fanelli G,Cetani F,Marcocci C,Bevilacqua G,Naccarato AG

更新日期：2006-07-01 00:00:00

abstract：:Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...

journal_title：Endocrine pathology

authors： Díaz Del Arco C,Díaz Pérez JÁ,Ortega Medina L,Sastre Valera J,Fernández Aceñero MJ

更新日期：2016-12-01 00:00:00

abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...

journal_title：Endocrine pathology

authors： Rego KG,Billerbeck AE,Targovnik HM,Santos CL,Alkmin MG,Barbosa S,Camargo R,Medeiros-Neto G

更新日期：1997-04-01 00:00:00

abstract：:Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...

journal_title：Endocrine pathology

authors： Lubensky IA,Zhuang Z

更新日期：2007-10-01 00:00:00

abstract：:A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...

journal_title：Endocrine pathology

authors： Chetty R,Kennedy M,Ezzat S,Asa SL

更新日期：2004-07-01 00:00:00

abstract：:Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...

journal_title：Endocrine pathology

authors： Zheng Z,Zhou X,Cai Y,Chen E,Zhang X,Wang O,Wang Q,Liu H

更新日期：2018-12-01 00:00:00

abstract：:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...

journal_title：Endocrine pathology

authors： Raphael SL,Asa SL

更新日期：1995-10-01 00:00:00

abstract：:Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recent...

journal_title：Endocrine pathology

authors： Zhang X,Guo M,Yang J,Zheng Y,Xiao Y,Liu W,Ren F

更新日期：2019-03-01 00:00:00

abstract：:The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...

journal_title：Endocrine pathology

authors： Chung SR,Baek JH,Lee JH,Lee YM,Sung TY,Chung KW,Hong SJ,Jeon MJ,Kim TY,Shong YK,Kim WB,Kim WG,Song DE

更新日期：2019-06-01 00:00:00

abstract：:The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...

journal_title：Endocrine pathology

authors： Lloyd RV,Carney JA,Ferreiro JA,Jin L,Thompson GB,Van Heerden JA,Grant CS,Wollan PC

更新日期：1995-01-01 00:00:00

abstract：:The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...

journal_title：Endocrine pathology

authors： Baser H,Ozdemir D,Cuhaci N,Aydin C,Ersoy R,Kilicarslan A,Cakir B

更新日期：2015-12-01 00:00:00

abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...

journal_title：Endocrine pathology

authors： Carr R,Ustun B,Chhieng D,Schofield K,Theoharis C,Hammers L,Adeniran AJ

更新日期：2013-06-01 00:00:00

abstract：:Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...

journal_title：Endocrine pathology

authors： Yokoyama S,Sano T,Tajitsu K,Kusumoto K

更新日期：2004-01-01 00:00:00

abstract：:Crohn's disease is one of the causes of secondary amyloidosis, which can lead to amyloid infiltration of the thyroid gland. It is essential to follow strict controls to prevent the appearance of a large amyloid goiter. Two patients with amyloid goiter secondary to Crohn's disease, with a large adipose tissue component...

journal_title：Endocrine pathology

authors： Febrero B,Ríos A,Rodríguez JM,Ferri B,Polo L,Parrilla P

更新日期：2012-12-01 00:00:00

abstract：:Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...

journal_title：Endocrine pathology

authors： Harach HR,Bergholm U

更新日期：1993-03-01 00:00:00