Abstract：
:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 expression has not been investigated in pituitary tumors. We analyzed the immunohistochemical expression of IMP3 in five normal pituitary tissues and 75 pituitary tumors (64 adenomas and 11 carcinomas) to determine if specific tumor types expressed IMP3 and if there were differences in IMP3 expression between adenomas and carcinomas. Immunohistochemical analysis showed that IMP3 was positive in four (80%) normal pituitaries with focal stain in a subset of normal anterior pituitary cells. IMP3 was expressed in 31% (20/64) of adenomas and in 36% (4/11) of carcinomas. A slightly higher level of IMP3 expression was observed in PRL-GH-TSH adenomas compared to the other types of pituitary adenomas. Expression of IMP3 was not significantly higher in carcinomas than in adenomas (p = 0.737). RT-PCR and Western Blotting supported the heterogeneous expression of IMP3. These results indicate that IMP3 is expressed both in normal and in neoplastic pituitary gland tissues without significant differences in expression levels in pituitary carcinomas.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Righi A,Zhang S,Jin L,Scheithauer BW,Kovacs K,Kovacs G,Goth MI,Korbonits M,Lloyd RVdoi
10.1007/s12022-009-9096-9subject
Has Abstractpub_date
2010-03-01 00:00:00pages
25-31issue
1eissn
1046-3976issn
1559-0097journal_volume
21pub_type
杂志文章abstract：:Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the ...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-010-9113-z
更新日期：2010-06-01 00:00:00
abstract：:Understanding the molecular mechanisms involved in thyroid cancer progression may provide targets for more effective treatment of aggressive thyroid cancers. Epithelial mesenchymal transition (EMT) is a major pathologic mechanism in tumor progression and is linked to the acquisition of stem-like properties of cancer c...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-013-9272-9
更新日期：2013-12-01 00:00:00
abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:15:3:241
更新日期：2004-10-01 00:00:00
abstract：:Hashimoto's thyroiditis is the archetype of organ-specific autoimmune disease. The key pathogenetic feature is the activation of thyroid-specific T-cells by properly presented endogenous thyroid antigens. There is strong indication that thyrocytes themselves present self-antigens, based on the finding of antigen prese...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739959
更新日期：1998-10-01 00:00:00
abstract：:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9420-0
更新日期：2016-06-01 00:00:00
abstract：:The question of whether thyroxine (T(4)) and thyrotropin-releasing hormone (TRH) affect mitoses in pituitary thyrotrophs (Tt) and somatotrophs (St) of hypothyroid rats was investigated. Fifteen day thyroidectomized (Tx) rats were used. Groups of Tx animals received T(4) or TRH or both. Except 6 and 24 h TRH groups, th...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739776
更新日期：1999-01-01 00:00:00
abstract：:Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:17:3:235
更新日期：2006-10-01 00:00:00
abstract：:We report clinicopathological features of a large series of synchronous multiple pituitary neuroendocrine tumors (PitNETs) of different cell lineages. Retrospective review of pathology records from 2001 to 2016 identified 13 synchronous multiple PitNETs from 1055 PitNETs classified using pituitary cell-lineage transcr...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9545-4
更新日期：2018-12-01 00:00:00
abstract：:Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9571-x
更新日期：2019-06-01 00:00:00
abstract：:The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02921341
更新日期：1992-03-01 00:00:00
abstract：:Pleomorphic leiomyosarcoma (PLMS) of the adrenal gland is a rare tumor in an unusual location. A primary PLMS of the left adrenal gland is reported in a 59-yr-old Mexican woman who presented progressive flank pain and weight loss. The tumor measured 16 cm in diameter, showed markedly pleomorphic and osteoclast-like gi...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:16:1:075
更新日期：2005-04-01 00:00:00
abstract：:Pheochromocytomas and paragangliomas are neuroendocrine neoplasias of neural crest origin. Genetic mutations that are characterized in other human neoplasms are rarely seen in these tumors. About 10% of the patients with pheochromocytomas and paragangliomas present with a family history of von Hippel-Lindau disease (V...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:4:329
更新日期：2003-01-01 00:00:00
abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-007-9002-2
更新日期：2008-04-01 00:00:00
abstract：:Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:16:3:173
更新日期：2005-10-01 00:00:00
abstract：:Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:4:351
更新日期：2004-01-01 00:00:00
abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739706
更新日期：1997-04-01 00:00:00
abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739915
更新日期：1996-04-01 00:00:00
abstract：:We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be mor...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9575-6
更新日期：2019-06-01 00:00:00
abstract：:A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneo...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9013-7
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:16:4:331
更新日期：2005-01-01 00:00:00
abstract：:A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:2:141
更新日期：2004-07-01 00:00:00
abstract：:Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-009-9087-x
更新日期：2009-01-01 00:00:00
abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-020-09650-1
更新日期：2021-01-04 00:00:00
abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915391
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-003-0017-z
更新日期：2003-10-01 00:00:00
abstract：:Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In add...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-008-9054-y
更新日期：2009-04-01 00:00:00
abstract：:In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739828
更新日期：1999-06-01 00:00:00
abstract：:Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9024-4
更新日期：2008-10-01 00:00:00
abstract：:The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9476-5
更新日期：2017-06-01 00:00:00
abstract：:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739883
更新日期：1995-10-01 00:00:00
