Abstract:
:Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the adrenal gland of a 71-year-old Arab man. On histology, besides the typical morphologic features seen in solitary fibrous tumor, the neoplasm also exhibited unusual features on immunohistochemistry such as positive staining for cytokeratin AE1/3 and calponin in conjunction with diffuse expression for S-100. The genetic tests for t(X:18) as seen in synovial sarcoma were negative, and the overall histological appearance favored a diagnosis of solitary fibrous tumor. To the best of our knowledge, this report represents the fifth case of a solitary fibrous tumor primarily occurring in the adrenal gland. The differential diagnoses of this neoplasm in our case and a brief summary of solitary fibrous tumor primarily involving the various endocrine organs are presented.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Ho YH,Yap WM,Chuah KLdoi
10.1007/s12022-010-9113-zsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
125-9issue
2eissn
1046-3976issn
1559-0097journal_volume
21pub_type
杂志文章,评审abstract::Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739692
更新日期:1998-01-01 00:00:00
abstract::Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739706
更新日期:1997-04-01 00:00:00
abstract::Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9240-4
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-003-0017-z
更新日期:2003-10-01 00:00:00
abstract::The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921341
更新日期:1992-03-01 00:00:00
abstract::A cell fine of human medullary carcinoma of the thyroid, abundantly producing calcitonin (Ct) and related hormones, has proved remarkably useful as an endocrine tumor model for the study of the secretion mechanism. This cell line (TT cell) was used in studies to elucidate the dynamics of the release of Ct and chromogr...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915322
更新日期:1991-03-01 00:00:00
abstract::Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. Th...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9079-x
更新日期:2009-10-01 00:00:00
abstract::A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneo...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9013-7
更新日期:2007-01-01 00:00:00
abstract::The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9577-4
更新日期:2019-06-01 00:00:00
abstract::The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915332
更新日期:1991-06-01 00:00:00
abstract::The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739950
更新日期:1998-04-01 00:00:00
abstract::Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738783
更新日期:1997-10-01 00:00:00
abstract::Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9024-4
更新日期:2008-10-01 00:00:00
abstract::Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9333-8
更新日期:2014-12-01 00:00:00
abstract::Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9466-z
更新日期:2017-03-01 00:00:00
abstract::Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739972
更新日期:1996-07-01 00:00:00
abstract::We report a very rare case of Cushing's syndrome caused by an ileal adrenocorticotrophin-secreting well-differentiated endocrine carcinoma with liver metastases. A 62-yr-old woman presented with clinical and biological signs suggestive of paraneoplastic Cushing's syndrome Radiological investigations, including magneti...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:11:4:359
更新日期:2000-01-01 00:00:00
abstract::Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACT...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-012-9197-8
更新日期:2012-06-01 00:00:00
abstract::We report clinicopathological features of a large series of synchronous multiple pituitary neuroendocrine tumors (PitNETs) of different cell lineages. Retrospective review of pathology records from 2001 to 2016 identified 13 synchronous multiple PitNETs from 1055 PitNETs classified using pituitary cell-lineage transcr...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9545-4
更新日期:2018-12-01 00:00:00
abstract::Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02914490
更新日期:1993-03-01 00:00:00
abstract::The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-017-9476-5
更新日期:2017-06-01 00:00:00
abstract::Neuroendocrine secretory protein-55 (NESP-55) is a recently described member of the chromogranin family and appears to be a marker of the constitutive secretory pathway in certain neural, neuroendocrine, and endocrine cell types. It has been shown to be selectively expressed in tumors differentiating towards the adren...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-011-9162-y
更新日期:2011-09-01 00:00:00
abstract::In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739828
更新日期:1999-06-01 00:00:00
abstract::Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9518-7
更新日期:2018-03-01 00:00:00
abstract::Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:2:147
更新日期:2001-07-01 00:00:00
abstract::A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:15:2:141
更新日期:2004-07-01 00:00:00
abstract::The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. We report the clinical history and the laboratory, imaging, and histopathological findings of a 47-year-old man affecte...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9303-1
更新日期:2014-09-01 00:00:00
abstract::The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09630-5
更新日期:2020-09-01 00:00:00
abstract::Neoplastic plasma cell involvement of thyroid is an uncommon condition, and it may involve thyroid in multiple myeloma or solitary plasmacytoma. Its clinical and pathological features are not well understood. We present a rare case of synchronous thyroid involvement in plasma cell leukemia presenting as thyroid nodule...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9392-5
更新日期:2015-12-01 00:00:00
abstract::The history of pituitary pathology is a long one that dates back to biblical times, but the last 25 years have represented an era of "coming of age." The role of the pituitary in health and disease was the subject of many studies over the last century. With the development of electron microscopy, immunoassays, and imm...
journal_title:Endocrine pathology
pub_type: 历史文章,杂志文章
doi:10.1007/s12022-013-9284-5
更新日期:2014-03-01 00:00:00