Abstract:
:Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is not known whether the absence of immunoreactive PNMT is paralleled by a lack of PNMT mRNA. The mRNA of tyrosine hydroxylase (TI-I) and PNMT in seven pheochromocytomas, five NE-type and two E-type tumors, were examined by Northern blot analysis and in situ hybridization (ISH) technique. TH mRNA was detected in all tumors but PNMT mRNA was limited only to the E-type tumors. In addition to our previous immunohistochemical study of 70 pheochromocytomas and paragangliomas in which all pheochromocytomas had cells immunoreactive to TH, but PNMT was expressed only in E-type, we concluded that NE-type pheochromocytoma lacks PNMT both at the mRNA and protein levels, resulting in an inability to produce E. The essential difference between NE-type and E-type pheochromocytoma is that the NE-type lacks PNMT.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Kimura N,Togo A,Sugimoto T,Nata K,Okamoto H,Nagatsu I,Nagura Hdoi
10.1007/BF02739972keywords:
subject
Has Abstractpub_date
1996-07-01 00:00:00pages
131-136issue
2eissn
1046-3976issn
1559-0097pii
EP0702131journal_volume
7pub_type
杂志文章abstract::The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...
journal_title:Endocrine pathology
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journal_title:Endocrine pathology
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journal_title:Endocrine pathology
pub_type: 杂志文章
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更新日期:1995-10-01 00:00:00
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journal_title:Endocrine pathology
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doi:10.1007/BF02915305
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02914989
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9401-8
更新日期:2015-12-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921341
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journal_title:Endocrine pathology
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921371
更新日期:1994-03-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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