Synchronous Thyroid Involvement in Plasma Cell Leukemia Masquerading as Hashimoto's Thyroiditis: Role of Ancillary Cytology Techniques in Diagnostic Workup.


:Neoplastic plasma cell involvement of thyroid is an uncommon condition, and it may involve thyroid in multiple myeloma or solitary plasmacytoma. Its clinical and pathological features are not well understood. We present a rare case of synchronous thyroid involvement in plasma cell leukemia presenting as thyroid nodule with primary hypothyroidism. Simultaneous cytology, immunocytochemistry, FISH analysis with 13q14.3 and TP53 on cytology smears and haematology workup were performed to diagnose and to understand disease pathobiology with poor outcome.


Endocr Pathol


Endocrine pathology


Tandon A,Paul TR,Singh R,Narendra AM




Has Abstract


2015-12-01 00:00:00














  • Granular cell tumour of the thyroid gland: a case report and review of the literature.

    abstract::Granular cell tumours of the thyroid gland are rare, with only six previously reported cases in the English literature. Current histological, immunohistochemical and electron microscopic evidence favours a neural/Schwannian relationship. A case of a granular cell tumour of the thyroid gland in a healthy 36-year-old wo...

    journal_title:Endocrine pathology

    pub_type: 杂志文章,评审


    authors: Bowry M,Almeida B,Jeannon JP

    更新日期:2011-03-01 00:00:00

  • Xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.

    abstract::Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Yokoyama S,Sano T,Tajitsu K,Kusumoto K

    更新日期:2004-01-01 00:00:00

  • Cushing's syndrome in a child with pancreatic acinar cell carcinoma.

    abstract::A case of pancreatic acinar cell tumor (ACC) is presented in a 10-year-old boy. The tumor manifested clinically with Cushing's syndrome, high serum adrenocorticotropic hormone (ACTH) and cortisol concentrations. In addition, excessive serum levels of alpha-fetoprotein (AFP) were detected. Surgical resection was not po...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Illyés G,Luczay A,Benyó G,Kálmán A,Borka K,Köves K,Rácz K,Tulassay T,Schaff Z

    更新日期:2007-07-01 00:00:00

  • Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism.

    abstract::We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis. The patient was diagnosed with breast cancer and received chemotherapy 3 years before parathyroidectomy. The question can be raised whether chemotherapeutic agents may damage pa...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Kovacs K,Bell CD,Juco J,Rotondo F,Anderson J

    更新日期:2007-04-01 00:00:00

  • Why is the adrenal adrenergic?

    abstract::The adrenal gland is the body's primary source for epinephrine production and release, and the chromaffin cells that comprise the adrenal medulla possess all of the catecholamine biosynthetic machinery, including phenylethanolamine N-methyltransferase (PNMT), the enzyme synthesizing epinephrine from norepinephrine. In...

    journal_title:Endocrine pathology

    pub_type: 杂志文章,评审


    authors: Wong DL

    更新日期:2003-04-01 00:00:00

  • Microvessel density in human normal and neoplastic parathyroids.

    abstract::Objective. Information on angiogenesis in parathyroid pathology is scanty and in particular no data are available in parathyroid carcinomas. The aim of this study was to analyze angiogenesis as microvascular density (MVD) in parathyroid neoplastic progression from normal gland to adenoma and carcinoma. Methods. Sectio...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Viacava P,Bocci G,Fanelli G,Cetani F,Marcocci C,Bevilacqua G,Naccarato AG

    更新日期:2006-07-01 00:00:00

  • Clinical, Pathological, and Molecular Studies of Two Families with Iodide Organification Defect.

    abstract::Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Rego KG,Billerbeck AE,Targovnik HM,Santos CL,Alkmin MG,Barbosa S,Camargo R,Medeiros-Neto G

    更新日期:1997-04-01 00:00:00

  • Capsular Invasion Matters Also in "Papillary Patterned" Tumors: A Study on 121 Cases of Encapsulated Conventional Variant of Papillary Thyroid Carcinoma.

    abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Akbulut D,Kuz ED,Kursun N,Dizbay Sak S

    更新日期:2021-01-04 00:00:00

  • Hyalinizing trabecular tumor of the thyroid: an update.

    abstract::Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Nosé V,Volante M,Papotti M

    更新日期:2008-04-01 00:00:00

  • Rapid Reticulin Fiber Staining Method is Helpful for the Diagnosis of Pituitary Adenoma in Frozen Section.

    abstract::Approximately 90% of neoplasms found in the sellar region are adenoma of the pituitary gland. The use of frozen sections for the diagnosis of pituitary adenomas has an accuracy of 90% and is useful in evaluating complete tumor removal. However, it is sometimes difficult to diagnose pituitary adenomas using frozen sect...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Noh S,Kim SH,Cho NH,Kim SH

    更新日期:2015-05-01 00:00:00

  • Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome.

    abstract::A 59-yr old female presented with Cushing's syndrome due to ectopic ACTH production. At the time of initial diagnosis an obvious source for the Cushing's syndrome was not found and the patient was treated with bilateral adrenalectomy. Three years later she presented with hyperpigmentation and evidence of ACTH overprod...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Chetty R,Serra S

    更新日期:2005-07-01 00:00:00

  • Discordant Expression of Ii and HLA-DR in Thyrocytes: A Possible Pathogenetic Factor in Hashimoto's Thyroiditis.

    abstract::Hashimoto's thyroiditis is the archetype of organ-specific autoimmune disease. The key pathogenetic feature is the activation of thyroid-specific T-cells by properly presented endogenous thyroid antigens. There is strong indication that thyrocytes themselves present self-antigens, based on the finding of antigen prese...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Yu M,Xu M,Savas L,Khan A

    更新日期:1998-10-01 00:00:00

  • The Prevalence of Extranodal Extension in Papillary Thyroid Cancer Based on the Size of the Metastatic Node: Adverse Histologic Features Are Not Limited to Larger Lymph Nodes.

    abstract::Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Rowe ME,Ozbek U,Machado RA,Yue LE,Hernandez-Prera JC,Valentino A,Qazi M,Brandwein-Weber M,Liu X,Wenig BM,Urken ML

    更新日期:2018-03-01 00:00:00

  • Hurthle cell carcinoma arising from thyroid papillary carcinoma.

    abstract::Hurthle cell carcinoma of the thyroid is generally considered to be a subtype of follicular carcinoma. We report a case of a small solitary usual-type papillary carcinoma of the thyroid, with metastatic tumor in cervical lymph nodes. The lymph node tumor consisted of both tall-cell papillary carcinoma and Hurthle cell...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Zwi LJ,LiVolsi VA

    更新日期:2002-10-01 00:00:00

  • Pancreatic endocrine pathology in von Hippel-Lindau disease: an expanding spectrum of lesions.

    abstract::A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Chetty R,Kennedy M,Ezzat S,Asa SL

    更新日期:2004-07-01 00:00:00

  • Xanthomatous Hypophysitis Is Associated with Ruptured Rathke's Cleft Cyst.

    abstract::Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Duan K,Asa SL,Winer D,Gelareh Z,Gentili F,Mete O

    更新日期:2017-03-01 00:00:00

  • Bronchial Paraganglioma with SDHB Deficiency.

    abstract::Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Ghigna MR,Dorfmuller P,Crutu A,Fadel E,de Montpréville VT

    更新日期:2016-12-01 00:00:00

  • TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway.

    abstract::Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Zheng Z,Zhou X,Cai Y,Chen E,Zhang X,Wang O,Wang Q,Liu H

    更新日期:2018-12-01 00:00:00

  • Homogeneous MMR Deficiency Throughout the Entire Tumor Mass Occurs in a Subset of Colorectal Neuroendocrine Carcinomas.

    abstract::Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Fraune C,Simon R,Hube-Magg C,Makrypidi-Fraune G,Kluth M,Büscheck F,Amin T,Viol F,Fehrle W,Dum D,Höflmayer D,Burandt E,Clauditz TS,Perez D,Izbicki J,Wilczak W,Sauter G,Steurer S,Schrader J

    更新日期:2020-06-01 00:00:00

  • Reliability of Ki-67 Determination in FNA Samples for Grading Pancreatic Neuroendocrine Tumors.

    abstract::Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Díaz Del Arco C,Díaz Pérez JÁ,Ortega Medina L,Sastre Valera J,Fernández Aceñero MJ

    更新日期:2016-12-01 00:00:00

  • Analysis of IMP3 expression in normal and neoplastic human pituitary tissues.

    abstract::Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Righi A,Zhang S,Jin L,Scheithauer BW,Kovacs K,Kovacs G,Goth MI,Korbonits M,Lloyd RV

    更新日期:2010-03-01 00:00:00

  • BRAF mutation is unusual in chronic lymphocytic thyroiditis-associated papillary thyroid carcinomas and absent in non-neoplastic nuclear atypia of thyroiditis.

    abstract::Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Sargent R,LiVolsi V,Murphy J,Mantha G,Hunt JL

    更新日期:2006-10-01 00:00:00

  • ACTH and alpha-subunit are co-expressed in rare human pituitary corticotroph cell adenomas proposed to originate from ACTH-committed early pituitary progenitor cells.

    abstract::The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Suzuki M,Egashira N,Kajiya H,Minematsu T,Takekoshi S,Tahara S,Sanno N,Teramoto A,Osamura RY

    更新日期:2008-04-01 00:00:00

  • Pituitary Sex Steroid Receptors: Localization and Function.

    abstract::The pituitary contains estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR). In accordance with immunocytochemistry, it is agreed that sex hormone receptors reside into the nucleus. All three receptors are found predominantly in gonadotrophs and lactotrophs, and less frequently in other cell ...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Stefaneanu L

    更新日期:1997-07-01 00:00:00

  • Analysis of Newly Identified and Rare Synonymous Genetic Variants in the RET Gene in Patients with Medullary Thyroid Carcinoma in Polish Population.

    abstract::Gain-of-function germline mutations of the RET proto-oncogene are responsible for initiation of carcinogenesis within the thyroid gland and development of hereditary form of medullary thyroid carcinoma and MEN2 syndrome. Genotype-phenotype correlations are established for most RET mutations, but the importance of the ...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Sromek M,Czetwertyńska M,Tarasińska M,Janiec-Jankowska A,Zub R,Ćwikła M,Nowakowska D,Chechlińska M

    更新日期:2017-09-01 00:00:00

  • Molecular genetic events in gastrointestinal and pancreatic neuroendocrine tumors.

    abstract::Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...

    journal_title:Endocrine pathology

    pub_type: 杂志文章,评审


    authors: Lubensky IA,Zhuang Z

    更新日期:2007-10-01 00:00:00

  • HLA-D Antigen Expression and Langerhans' Cell Infiltrates in Thyroid Tumors.

    abstract::Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Raphael SL,Asa SL

    更新日期:1995-10-01 00:00:00

  • Negative Results on Thyroid Molecular Testing Decrease Rates of Surgery for Indeterminate Thyroid Nodules.

    abstract::Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Jug R,Parajuli S,Ahmadi S,Jiang XS

    更新日期:2019-06-01 00:00:00

  • Pituitary adenoma with "honeycomb Golgi" appearance showing a phenotypic change at recurrence from clinically nonfunctioning to typical Cushing disease.

    abstract::An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Sano T,Kovacs K,Asa SL,Yamada S,Sanno N,Yokoyama S,Takami H

    更新日期:2002-07-01 00:00:00

  • Immunohistochemical Analysis of the Cell Cycle-Associated Antigens Ki-67 and Retinoblastoma Protein in Parathyroid Carcinomas and Adenomas.

    abstract::The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...

    journal_title:Endocrine pathology

    pub_type: 杂志文章


    authors: Lloyd RV,Carney JA,Ferreiro JA,Jin L,Thompson GB,Van Heerden JA,Grant CS,Wollan PC

    更新日期:1995-01-01 00:00:00