Abstract：
:A 59-yr old female presented with Cushing's syndrome due to ectopic ACTH production. At the time of initial diagnosis an obvious source for the Cushing's syndrome was not found and the patient was treated with bilateral adrenalectomy. Three years later she presented with hyperpigmentation and evidence of ACTH overproduction. This time a CT scan localized a mass to the tail of the pancreas and a distal pancreatectomy was performed. The mass was composed of compact plump spindle cells arranged in interlacing fascicles, was well circumscribed, and did not display angioinvasion. Although isolated punctate foci of necrosis were noted, the overall mitotic count was 1 per 10 high power fields. Immunohistochemistry showed the tumor to be positive for chromogranin, synaptophysin, and ACTH. This case highlights an unusual histological variant of pancreatic endocrine tumor (PET), namely, one composed almost exclusively of interlacing spindle-shaped cells. This raises a wide differential diagnosis and the use of immunohistochemistry is required to arrive at the correct diagnosis. ACTH-producing PET are usually aggressive lesions with metastases at the time of presentation and aggressive biological behavior. However, this case was characterized by an indolent clinical course.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Chetty R,Serra Sdoi
10.1385/ep:16:2:145keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
145-51issue
2eissn
1046-3976issn
1559-0097pii
EP:16:2:145journal_volume
16pub_type
杂志文章abstract：:Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739692
更新日期：1998-01-01 00:00:00
abstract：:Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:4:351
更新日期：2004-01-01 00:00:00
abstract：:Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9518-7
更新日期：2018-03-01 00:00:00
abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915391
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-003-0017-z
更新日期：2003-10-01 00:00:00
abstract：:Goblet cell carcinoid (GCC) of the appendix is a rare entity, of which both the histogenesis and biologic behavior remain controversial, and prognostic tools and therapeutic strategies for this unusual tumor have yet to be defined. The aim of this study was to analyze expression of E-cadherin and b-catenin in GCCs of ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:13:1:47
更新日期：2002-04-01 00:00:00
abstract：:Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACT...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-012-9197-8
更新日期：2012-06-01 00:00:00
abstract：:Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:17:3:235
更新日期：2006-10-01 00:00:00
abstract：:We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be mor...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9575-6
更新日期：2019-06-01 00:00:00
abstract：:The cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity that is associated with familial adenomatous polyposis (FAP). We report a case of a young lady with an incidentally discovered right-sided neck nodule on ultrasonography with a diagnosis of CMV-PTC confirmed on thyroid...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-013-9274-7
更新日期：2014-09-01 00:00:00
abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739706
更新日期：1997-04-01 00:00:00
abstract：:Using conventional histological technique, we investigated 44 adenomas (31 men, 13 women) incidentally found in 36 pituitaries (25 men, 11 women) obtained from 1,117 unselected autopsies. The overall incidence of adenomas was 3.2% (men, 3.8%; women, 2.4%) without any significant sex predominance. Size, age distributio...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02921376
更新日期：1994-06-01 00:00:00
abstract：:Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. Th...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-009-9079-x
更新日期：2009-10-01 00:00:00
abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-007-9002-2
更新日期：2008-04-01 00:00:00
abstract：:The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-015-9401-8
更新日期：2015-12-01 00:00:00
abstract：:Neuroendocrine secretory protein-55 (NESP-55) is a recently described member of the chromogranin family and appears to be a marker of the constitutive secretory pathway in certain neural, neuroendocrine, and endocrine cell types. It has been shown to be selectively expressed in tumors differentiating towards the adren...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-011-9162-y
更新日期：2011-09-01 00:00:00
abstract：:Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:2:107
更新日期：2003-07-01 00:00:00
abstract：:The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9476-5
更新日期：2017-06-01 00:00:00
abstract：:In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-013-9263-x
更新日期：2013-12-01 00:00:00
abstract：:A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneo...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9013-7
更新日期：2007-01-01 00:00:00
abstract：:An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:13:2:125
更新日期：2002-07-01 00:00:00
abstract：:The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-020-09630-5
更新日期：2020-09-01 00:00:00
abstract：:Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739931
更新日期：1997-01-01 00:00:00
abstract：:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9420-0
更新日期：2016-06-01 00:00:00
abstract：:Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9471-x
更新日期：2017-03-01 00:00:00
abstract：:The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less t...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9483-6
更新日期：2017-06-01 00:00:00
abstract：:Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9024-4
更新日期：2008-10-01 00:00:00
abstract：:A cell fine of human medullary carcinoma of the thyroid, abundantly producing calcitonin (Ct) and related hormones, has proved remarkably useful as an endocrine tumor model for the study of the secretion mechanism. This cell line (TT cell) was used in studies to elucidate the dynamics of the release of Ct and chromogr...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915322
更新日期：1991-03-01 00:00:00
abstract：:Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid ca...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-010-9129-4
更新日期：2010-12-01 00:00:00
abstract：:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739883
更新日期：1995-10-01 00:00:00
