Abstract:
:Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid carcinomas. Additionally, activating mutations of another subtype of G protein (GNAS1) are frequently found in hyperfunctioning thyroid adenomas, making it plausible that GNAq-activating mutations could also be found in some of these nodules. To investigate thyroid papillary carcinomas and thyroid hyperfunctioning nodules for GNAq mutations in exon 5, codon 209, a total of 32 RET/PTC, BRAF, and RAS negative thyroid papillary carcinomas and 13 hyperfunctioning thyroid nodules were evaluated. No mutations were identified. Although plausible, GNAq mutations seem not to play an important role in the development of thyroid follicular neoplasms, either benign hyperfunctioning nodules or malignant papillary carcinomas. Our results are in accordance with the literature, in which no GNAq hotspot mutations were found in thyroid papillary carcinomas, as well as in an extensive panel of other tumors. The molecular basis for MAP-kinase pathway activation in RET-PTC/BRAF/RAS negative thyroid carcinomas remains to be determined.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Cassol CA,Guo M,Ezzat S,Asa SLdoi
10.1007/s12022-010-9129-4subject
Has Abstractpub_date
2010-12-01 00:00:00pages
250-2issue
4eissn
1046-3976issn
1559-0097journal_volume
21pub_type
杂志文章abstract::Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cell...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915304
更新日期:1993-09-01 00:00:00
abstract::Aldosterone-producing adenoma (APA) consisting of pure zona glomerulosa (ZG)-type cells is extremely rare, and primary aldosteronism complicated by pregnancy is also rare. We report a case of APA discovered in a 32-year-old pregnant woman who visited our hospital for hypertension and hypokalemia at 26 weeks gestation....
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9060-8
更新日期:2009-04-01 00:00:00
abstract::The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. We report the clinical history and the laboratory, imaging, and histopathological findings of a 47-year-old man affecte...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9303-1
更新日期:2014-09-01 00:00:00
abstract::A case of pancreatic acinar cell tumor (ACC) is presented in a 10-year-old boy. The tumor manifested clinically with Cushing's syndrome, high serum adrenocorticotropic hormone (ACTH) and cortisol concentrations. In addition, excessive serum levels of alpha-fetoprotein (AFP) were detected. Surgical resection was not po...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-0018-4
更新日期:2007-07-01 00:00:00
abstract::Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the ...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-010-9113-z
更新日期:2010-06-01 00:00:00
abstract::The cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity that is associated with familial adenomatous polyposis (FAP). We report a case of a young lady with an incidentally discovered right-sided neck nodule on ultrasonography with a diagnosis of CMV-PTC confirmed on thyroid...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-013-9274-7
更新日期:2014-09-01 00:00:00
abstract::Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9571-x
更新日期:2019-06-01 00:00:00
abstract::Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9422-y
更新日期:2016-12-01 00:00:00
abstract::A case of ectopic thymic tissue of the thyroid in a 30-year-old woman with Graves' disease is reported. The thyroidectomy specimen, removed because of failure of medical therapy, showed a continuous track of thymic tissue extending from the center of the gland to the capsule along an interiobular septum. This finding ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915305
更新日期:1993-09-01 00:00:00
abstract::Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9559-y
更新日期:2019-03-01 00:00:00
abstract::The question of whether thyroxine (T(4)) and thyrotropin-releasing hormone (TRH) affect mitoses in pituitary thyrotrophs (Tt) and somatotrophs (St) of hypothyroid rats was investigated. Fifteen day thyroidectomized (Tx) rats were used. Groups of Tx animals received T(4) or TRH or both. Except 6 and 24 h TRH groups, th...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739776
更新日期:1999-01-01 00:00:00
abstract::The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9401-8
更新日期:2015-12-01 00:00:00
abstract::The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915332
更新日期:1991-06-01 00:00:00
abstract::An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:13:2:125
更新日期:2002-07-01 00:00:00
abstract::Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739706
更新日期:1997-04-01 00:00:00
abstract::Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9455-2
更新日期:2016-12-01 00:00:00
abstract::The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739950
更新日期:1998-04-01 00:00:00
abstract::Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:2:147
更新日期:2001-07-01 00:00:00
abstract::Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09612-7
更新日期:2020-06-01 00:00:00
abstract::Approximately 90% of neoplasms found in the sellar region are adenoma of the pituitary gland. The use of frozen sections for the diagnosis of pituitary adenomas has an accuracy of 90% and is useful in evaluating complete tumor removal. However, it is sometimes difficult to diagnose pituitary adenomas using frozen sect...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9370-y
更新日期:2015-05-01 00:00:00
abstract::Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:17:3:235
更新日期:2006-10-01 00:00:00
abstract::Granular cell tumours of the thyroid gland are rare, with only six previously reported cases in the English literature. Current histological, immunohistochemical and electron microscopic evidence favours a neural/Schwannian relationship. A case of a granular cell tumour of the thyroid gland in a healthy 36-year-old wo...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-011-9146-y
更新日期:2011-03-01 00:00:00
abstract::Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:15:4:351
更新日期:2004-01-01 00:00:00
abstract::Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739877
更新日期:1995-07-01 00:00:00
abstract::Breast carcinomas often metastasize into various organs, most commonly into the lung and rather infrequently into the pineal gland. There were only 20 cases of the latter recorded until 1950. Currently, the total number of reported cases, including this report, is 74. At Sunnybrook Health Science Centre, between 1984 ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921371
更新日期:1994-03-01 00:00:00
abstract::Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915325
更新日期:1991-03-01 00:00:00
abstract::Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9518-7
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:4:331
更新日期:2005-01-01 00:00:00
abstract::Transcription factors play specific roles in the development and differentiation of normal pituitary tissues and pituitary adenoma. The transcription factor, muscle segment homeobox 1 (MSX1), which belongs to the homeobox gene family, binds the promoter region of the glycoprotein hormone alpha-subunit (SU) in TSH-prod...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9021-7
更新日期:2008-04-01 00:00:00
abstract::Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9096-9
更新日期:2010-03-01 00:00:00