Abstract:
:An adenoma resected from a 49-yr-old woman was clinically nonfunctioning but immunopositive for adrenocorticotropic hormone (ACTH) in a few cells. Electron microscopy demonstrated a vacuolar change in Golgi complexes known as "honeycomb Golgi." Recurrent adenoma resected 11 mo later was positive for ACTH in more cells than in the initial one. Two months later the patient presented with typical signs and symptoms of Cushing disease with elevated blood cortisol and ACTH levels and was treated by gamma knife radiotherapy. Among adenomas that are initially clinically silent but became functionally active with recurrence, corticotroph adenomas seem to be the most frequent. Study of transcription factors will be helpful to clarify whether adenomas with honeycomb Golgi represent exclusively gonadotroph adenomas.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Sano T,Kovacs K,Asa SL,Yamada S,Sanno N,Yokoyama S,Takami Hdoi
10.1385/ep:13:2:125keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
125-30issue
2eissn
1046-3976issn
1559-0097pii
EP:13:2:125journal_volume
13pub_type
杂志文章abstract::In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9263-x
更新日期:2013-12-01 00:00:00
abstract::Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9455-2
更新日期:2016-12-01 00:00:00
abstract::Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-017-9471-x
更新日期:2017-03-01 00:00:00
abstract::Approximately 90% of neoplasms found in the sellar region are adenoma of the pituitary gland. The use of frozen sections for the diagnosis of pituitary adenomas has an accuracy of 90% and is useful in evaluating complete tumor removal. However, it is sometimes difficult to diagnose pituitary adenomas using frozen sect...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9370-y
更新日期:2015-05-01 00:00:00
abstract::The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. We report the clinical history and the laboratory, imaging, and histopathological findings of a 47-year-old man affecte...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9303-1
更新日期:2014-09-01 00:00:00
abstract::The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921341
更新日期:1992-03-01 00:00:00
abstract::Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recent...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9557-0
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:4:331
更新日期:2005-01-01 00:00:00
abstract::Using conventional histological technique, we investigated 44 adenomas (31 men, 13 women) incidentally found in 36 pituitaries (25 men, 11 women) obtained from 1,117 unselected autopsies. The overall incidence of adenomas was 3.2% (men, 3.8%; women, 2.4%) without any significant sex predominance. Size, age distributio...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921376
更新日期:1994-06-01 00:00:00
abstract::C cell hyperplasia is considered a precursor lesion for hereditary forms of medullary thyroid carcinoma. It has therefore been suggested as a morphological marker to distinguish hereditary from sporadic medullary thyroid carcinoma and to triage genetic testing in resource poor settings. However, numerous definitions f...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9567-6
更新日期:2019-06-01 00:00:00
abstract::Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9240-4
更新日期:2013-06-01 00:00:00
abstract::In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739828
更新日期:1999-06-01 00:00:00
abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09650-1
更新日期:2021-01-04 00:00:00
abstract::Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739931
更新日期:1997-01-01 00:00:00
abstract::The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9401-8
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-003-0017-z
更新日期:2003-10-01 00:00:00
abstract::Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9333-8
更新日期:2014-12-01 00:00:00
abstract::Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9024-4
更新日期:2008-10-01 00:00:00
abstract::Solitary metastasis from prostate adenocarcinoma to thyroid gland is very rare and usually associated with other distal metastasis. This report describes for the first time isolated multiple bilateral thyroid metastasis from prostatic adenocarcinoma. A 67-year-old man who is known as a case of prostatic adenocarcinoma...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9232-4
更新日期:2013-03-01 00:00:00
abstract::Efforts to understand the pathobiology of pheochromocytomas and extra-adrenal paragangliomas have been spurred by genetic and gene expression profiling studies showing genotype-phenotype correlations in familial pheochromocytoma/paraganglioma syndromes and in some sporadic tumors. The current challenge is to relate ca...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-006-0003-3
更新日期:2006-01-01 00:00:00
abstract::Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin- and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report the first case of an association between craniopharyngioma ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9065-3
更新日期:2009-04-01 00:00:00
abstract::Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9096-9
更新日期:2010-03-01 00:00:00
abstract::Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:3:291
更新日期:2001-10-01 00:00:00
abstract::The incidence and histology of cysts in the adenohypophysis of adult male Wistar rats are reported. Of sixty pituitaries studied 13 of them (21.6%) presented a single cyst located in the pars distalis. The cysts varied in shape and size and were usually multilocular. Two of them were connected with the subdural space ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:1:63
更新日期:2001-04-01 00:00:00
abstract::A case of localized adiposity of the thyroid in a 35-year-old woman with a long history of steroid therapy for nephrotic syndrome is reported. A well-demarcated yellowish mass measuring 2 cm in diameter was found in the upper portion of the right lobe of the thyroid. Microscopically, this lesion was composed of mature...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915212
更新日期:1991-12-01 00:00:00
abstract::The BRAF(V600E) mutation is specific for thyroid papillary cancer (PTC) and correlates with PTCs invasiveness. This study investigated whether detection of BRAF(V600E) mutation can be performed on routinely stained FNABs. We also examined if establishment of the BRAF(V600E) mutation could help in identification of pat...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-011-9180-9
更新日期:2011-12-01 00:00:00
abstract::Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915325
更新日期:1991-03-01 00:00:00
abstract::Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACT...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-012-9197-8
更新日期:2012-06-01 00:00:00
abstract::The recent increase in the detection of papillary thyroid carcinoma (PTC) has been influenced by the finding of incidental tumours. To this group, carcinomas measuring less than 1 cm (the so-called microcarcinomas) as well as those above 1 cm belong. Analyzing a case series from our own experience, this paper focuses ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-014-9323-x
更新日期:2014-09-01 00:00:00
abstract::Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-007-9007-x
更新日期:2007-10-01 00:00:00