Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3: case report.

abstract：:Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In add...

journal_title：Endocrine pathology

authors： La Rosa S,Bernasconi B,Micello D,Finzi G,Capella C

更新日期：2009-04-01 00:00:00

abstract：:The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...

journal_title：Endocrine pathology

authors： Girolami I,Pantanowitz L,Mete O,Brunelli M,Marletta S,Colato C,Trimboli P,Crescenzi A,Bongiovanni M,Barbareschi M,Eccher A

更新日期：2020-09-01 00:00:00

abstract：:Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...

journal_title：Endocrine pathology

authors： Shan L,Iwasaki A,Utsunomiya H,Kawano I,Matsuura N,Kobayashi A,Kuma K,Kakudo K

更新日期：1995-07-01 00:00:00

abstract：:A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...

journal_title：Endocrine pathology

authors： Chetty R,Kennedy M,Ezzat S,Asa SL

更新日期：2004-07-01 00:00:00

abstract：:Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...

journal_title：Endocrine pathology

authors： Savin S,Cvejic D,Isic T,Petrovic I,Paunovic I,Tatic S,Havelka M

更新日期：2006-04-01 00:00:00

abstract：:CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. The scope of the present study was to validate their role in PC patients and investigate potential application in clinical practice. Data was collected from patients presenting to...

journal_title：Endocrine pathology

authors： Papaxoinis G,Nonaka D,O'Brien C,Sanderson B,Krysiak P,Mansoor W

更新日期：2017-03-01 00:00:00

abstract：:The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...

journal_title：Endocrine pathology

authors： Lloyd RV,Schroeder G,Bauman MD,Krook JE,Jin L,Goldberg RM,Farr GH Jr

更新日期：1998-04-01 00:00:00

abstract：:Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...

journal_title：Endocrine pathology

authors： Stilling GA,Bayliss JM,Jin L,Zhang H,Lloyd RV

更新日期：2005-10-01 00:00:00

abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...

journal_title：Endocrine pathology

authors： Abbona G,Papotti M,Gasparri G,Bussolati G

更新日期：1996-04-01 00:00:00

abstract：:Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...

journal_title：Endocrine pathology

authors： Jug R,Parajuli S,Ahmadi S,Jiang XS

更新日期：2019-06-01 00:00:00

abstract：:The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...

journal_title：Endocrine pathology

authors： Marin F,Kovacs K,Stefaneanu L,Horvath E,Cheng Z

更新日期：1992-03-01 00:00:00

abstract：:Aldosterone-producing adenoma (APA) consisting of pure zona glomerulosa (ZG)-type cells is extremely rare, and primary aldosteronism complicated by pregnancy is also rare. We report a case of APA discovered in a 32-year-old pregnant woman who visited our hospital for hypertension and hypokalemia at 26 weeks gestation....

journal_title：Endocrine pathology

authors： Shigematsu K,Nishida N,Sakai H,Igawa T,Suzuki S,Kawai K,Takahara O

更新日期：2009-04-01 00:00:00

abstract：:Solitary metastasis from prostate adenocarcinoma to thyroid gland is very rare and usually associated with other distal metastasis. This report describes for the first time isolated multiple bilateral thyroid metastasis from prostatic adenocarcinoma. A 67-year-old man who is known as a case of prostatic adenocarcinoma...

journal_title：Endocrine pathology

authors： Albsoul NM,Obeidat FN,Hadidy AM,Alzoubi MN,Taib AA,Shahait AD

更新日期：2013-03-01 00:00:00

abstract：:Nonradioisotopic electron microscopic (EM) in situ hybridization (ISH) (EM-SH) with biotinylated oligonucleotide probes is utilized for the ultrastructural visualization of pituitary hormone mRNA in rat pituitary cells. EMISH is an important tool for clarifying the intracellular localization of mRNA and the exact site...

journal_title：Endocrine pathology

authors： Matsuno A,Itoh J,Osamura RY,Watanabe K,Nagashima T

更新日期：1999-10-01 00:00:00

abstract：:We report clinicopathological features of a large series of synchronous multiple pituitary neuroendocrine tumors (PitNETs) of different cell lineages. Retrospective review of pathology records from 2001 to 2016 identified 13 synchronous multiple PitNETs from 1055 PitNETs classified using pituitary cell-lineage transcr...

journal_title：Endocrine pathology

authors： Mete O,Alshaikh OM,Cintosun A,Ezzat S,Asa SL

更新日期：2018-12-01 00:00:00

abstract：:Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on ...

journal_title：Endocrine pathology

authors： Cameselle-Teijeiro JM,Eloy C,Sobrinho-Simões M

更新日期：2020-09-01 00:00:00

abstract：:The adrenal gland is the body's primary source for epinephrine production and release, and the chromaffin cells that comprise the adrenal medulla possess all of the catecholamine biosynthetic machinery, including phenylethanolamine N-methyltransferase (PNMT), the enzyme synthesizing epinephrine from norepinephrine. In...

journal_title：Endocrine pathology

authors： Wong DL

更新日期：2003-04-01 00:00:00

abstract：:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...

journal_title：Endocrine pathology

authors： Onder S,Ozturk Sari S,Yegen G,Sormaz IC,Yilmaz I,Poyrazoglu S,Sanlı Y,Giles Senyurek Y,Kapran Y,Mete O

更新日期：2016-06-01 00:00:00

abstract：:The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...

journal_title：Endocrine pathology

authors： Chung SR,Baek JH,Lee JH,Lee YM,Sung TY,Chung KW,Hong SJ,Jeon MJ,Kim TY,Shong YK,Kim WB,Kim WG,Song DE

更新日期：2019-06-01 00:00:00

abstract：:In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...

journal_title：Endocrine pathology

authors： Fonseca E,Castanhas S,Sobrinho-Simoes M

更新日期：1996-01-01 00:00:00

abstract：:Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid ca...

journal_title：Endocrine pathology

authors： Cassol CA,Guo M,Ezzat S,Asa SL

更新日期：2010-12-01 00:00:00

abstract：:The question of whether thyroxine (T(4)) and thyrotropin-releasing hormone (TRH) affect mitoses in pituitary thyrotrophs (Tt) and somatotrophs (St) of hypothyroid rats was investigated. Fifteen day thyroidectomized (Tx) rats were used. Groups of Tx animals received T(4) or TRH or both. Except 6 and 24 h TRH groups, th...

journal_title：Endocrine pathology

authors： Quintanar-Stephano A,Valverde-R C,Kovacs K

更新日期：1999-01-01 00:00:00

abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...

journal_title：Endocrine pathology

authors： Hellman P,Bjerneroth G,Juhlin C,Ridefelt P,Rastad J,Åkerström G,Jüppner H

更新日期：1990-09-01 00:00:00

abstract：:A case of localized adiposity of the thyroid in a 35-year-old woman with a long history of steroid therapy for nephrotic syndrome is reported. A well-demarcated yellowish mass measuring 2 cm in diameter was found in the upper portion of the right lobe of the thyroid. Microscopically, this lesion was composed of mature...

journal_title：Endocrine pathology

authors： Morizumi H,Sano T,Tsuyuguchi M,Yoshinarl T,Morimoto S

更新日期：1991-12-01 00:00:00

abstract：:A 59-yr old female presented with Cushing's syndrome due to ectopic ACTH production. At the time of initial diagnosis an obvious source for the Cushing's syndrome was not found and the patient was treated with bilateral adrenalectomy. Three years later she presented with hyperpigmentation and evidence of ACTH overprod...

journal_title：Endocrine pathology

authors： Chetty R,Serra S

更新日期：2005-07-01 00:00:00

abstract：:The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less t...

journal_title：Endocrine pathology

authors： Glomski K,Nosé V,Faquin WC,Sadow PM

更新日期：2017-06-01 00:00:00

abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...

journal_title：Endocrine pathology

authors： Rego KG,Billerbeck AE,Targovnik HM,Santos CL,Alkmin MG,Barbosa S,Camargo R,Medeiros-Neto G

更新日期：1997-04-01 00:00:00

abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...

journal_title：Endocrine pathology

authors： Nosé V,Volante M,Papotti M

更新日期：2008-04-01 00:00:00

abstract：:A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneo...

journal_title：Endocrine pathology

authors： Lin J,Wasco MJ,Korobkin M,Doherty G,Giordano TJ

更新日期：2007-01-01 00:00:00

abstract：:Understanding the molecular mechanisms involved in thyroid cancer progression may provide targets for more effective treatment of aggressive thyroid cancers. Epithelial mesenchymal transition (EMT) is a major pathologic mechanism in tumor progression and is linked to the acquisition of stem-like properties of cancer c...

journal_title：Endocrine pathology

authors： Montemayor-Garcia C,Hardin H,Guo Z,Larrain C,Buehler D,Asioli S,Chen H,Lloyd RV

更新日期：2013-12-01 00:00:00