Abstract:
:The question of whether thyroxine (T(4)) and thyrotropin-releasing hormone (TRH) affect mitoses in pituitary thyrotrophs (Tt) and somatotrophs (St) of hypothyroid rats was investigated. Fifteen day thyroidectomized (Tx) rats were used. Groups of Tx animals received T(4) or TRH or both. Except 6 and 24 h TRH groups, the animals were sacrificed 12 h after injections. Unoperated euthyroid rats served as controls. In Tx group adenohypophysial mitoses were significantly increased. T(4) diminished mitoses in Tx rats. Mitotic counts were decreased in 6 and 24 h Tx groups, but increased in 12 h TRH group. TRH plus T(4) in Tx animals had a synergistic effect on adenohypophysial mitoses. In unoperated controls few mitoses were observed in Tt and more mitoses in St. In Tx rats more mitoses were seen in Tt than in St. T(4) alone failed to reduce mitoses in Tt but increased them in St. We concluded that T(4) affects Tt and St replication. In normal rats mitoses occur mainly in St. In Tx rats mitotic activity increased in Tt. TRH plus T(4) have a synergistic mitogenic effect on St. T(4) but not TRH affects St replication. It appears that the presence of T(4) is necessary for St multiplication.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Quintanar-Stephano A,Valverde-R C,Kovacs Kdoi
10.1007/BF02739776keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
335-341issue
4eissn
1046-3976issn
1559-0097pii
EP1004335journal_volume
10pub_type
杂志文章abstract::Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...
journal_title:Endocrine pathology
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更新日期:2004-01-01 00:00:00
abstract::Pediatric adrenocortical carcinoma is extremely rare with a prevalence of 0.3 per million. Adrenocortical neoplasms in children usually present with one of the endocrine abnormalities. Adrenocortical neoplasms cannot be easily diagnosed on cytopathology; hence, the cytomorphological features posing diagnostic dilemmas...
journal_title:Endocrine pathology
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doi:10.1007/s12022-010-9142-7
更新日期:2011-03-01 00:00:00
abstract::A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...
journal_title:Endocrine pathology
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更新日期:2004-07-01 00:00:00
abstract::The cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity that is associated with familial adenomatous polyposis (FAP). We report a case of a young lady with an incidentally discovered right-sided neck nodule on ultrasonography with a diagnosis of CMV-PTC confirmed on thyroid...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-013-9274-7
更新日期:2014-09-01 00:00:00
abstract::Neoplastic plasma cell involvement of thyroid is an uncommon condition, and it may involve thyroid in multiple myeloma or solitary plasmacytoma. Its clinical and pathological features are not well understood. We present a rare case of synchronous thyroid involvement in plasma cell leukemia presenting as thyroid nodule...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9392-5
更新日期:2015-12-01 00:00:00
abstract::Efforts to understand the pathobiology of pheochromocytomas and extra-adrenal paragangliomas have been spurred by genetic and gene expression profiling studies showing genotype-phenotype correlations in familial pheochromocytoma/paraganglioma syndromes and in some sporadic tumors. The current challenge is to relate ca...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-006-0003-3
更新日期:2006-01-01 00:00:00
abstract::Non-coding (nc)RNAs are divided into small ncRNAs and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are small ncRNAS which are around 22 nucleotides in length that mediate post-transcriptional gene silencing. LncRNAs are greater than 200 bp in length. Each ncRNA can have multiple targets and can be regulated by multiple g...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-016-9417-8
更新日期:2016-03-01 00:00:00
abstract::This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9420-0
更新日期:2016-06-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738783
更新日期:1997-10-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-0001-0
更新日期:2007-04-01 00:00:00
abstract::The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9577-4
更新日期:2019-06-01 00:00:00
abstract::Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
abstract::High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9516-9
更新日期:2018-09-01 00:00:00
abstract::Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9096-9
更新日期:2010-03-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739950
更新日期:1998-04-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739972
更新日期:1996-07-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739915
更新日期:1996-04-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921487
更新日期:1994-12-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915391
更新日期:1990-09-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-002-0002-y
更新日期:2002-10-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:4:331
更新日期:2005-01-01 00:00:00
abstract::Solitary metastasis from prostate adenocarcinoma to thyroid gland is very rare and usually associated with other distal metastasis. This report describes for the first time isolated multiple bilateral thyroid metastasis from prostatic adenocarcinoma. A 67-year-old man who is known as a case of prostatic adenocarcinoma...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9232-4
更新日期:2013-03-01 00:00:00
abstract::Granular cell tumours of the thyroid gland are rare, with only six previously reported cases in the English literature. Current histological, immunohistochemical and electron microscopic evidence favours a neural/Schwannian relationship. A case of a granular cell tumour of the thyroid gland in a healthy 36-year-old wo...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-011-9146-y
更新日期:2011-03-01 00:00:00
abstract::Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cell...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915304
更新日期:1993-09-01 00:00:00
abstract::Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09612-7
更新日期:2020-06-01 00:00:00
abstract::Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. Th...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9079-x
更新日期:2009-10-01 00:00:00
abstract::Pheochromocytomas and paragangliomas are neuroendocrine neoplasias of neural crest origin. Genetic mutations that are characterized in other human neoplasms are rarely seen in these tumors. About 10% of the patients with pheochromocytomas and paragangliomas present with a family history of von Hippel-Lindau disease (V...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:4:329
更新日期:2003-01-01 00:00:00
abstract::We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9464-1
更新日期:2017-12-01 00:00:00
abstract::Nonradioisotopic electron microscopic (EM) in situ hybridization (ISH) (EM-SH) with biotinylated oligonucleotide probes is utilized for the ultrastructural visualization of pituitary hormone mRNA in rat pituitary cells. EMISH is an important tool for clarifying the intracellular localization of mRNA and the exact site...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738881
更新日期:1999-10-01 00:00:00