Abstract:
:We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis. The patient was diagnosed with breast cancer and received chemotherapy 3 years before parathyroidectomy. The question can be raised whether chemotherapeutic agents may damage parathyroid cells leading to loss of self-tolerance and autoimmune chronic parathyroiditis.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Kovacs K,Bell CD,Juco J,Rotondo F,Anderson Jdoi
10.1007/s12022-007-0001-0subject
Has Abstractpub_date
2007-04-01 00:00:00pages
42-5issue
1eissn
1046-3976issn
1559-0097pii
EP:18:1:42journal_volume
18pub_type
杂志文章abstract::The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915332
更新日期:1991-06-01 00:00:00
abstract::Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin- and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report the first case of an association between craniopharyngioma ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9065-3
更新日期:2009-04-01 00:00:00
abstract::The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739915
更新日期:1996-04-01 00:00:00
abstract::High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9516-9
更新日期:2018-09-01 00:00:00
abstract::The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less t...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-017-9483-6
更新日期:2017-06-01 00:00:00
abstract::Hashimoto's thyroiditis is the archetype of organ-specific autoimmune disease. The key pathogenetic feature is the activation of thyroid-specific T-cells by properly presented endogenous thyroid antigens. There is strong indication that thyrocytes themselves present self-antigens, based on the finding of antigen prese...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739959
更新日期:1998-10-01 00:00:00
abstract::Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915452
更新日期:1991-09-01 00:00:00
abstract::The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:13:4:321
更新日期:2002-01-01 00:00:00
abstract::Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738783
更新日期:1997-10-01 00:00:00
abstract::Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human br...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:11:1:57
更新日期:2000-04-01 00:00:00
abstract::Solitary metastasis from prostate adenocarcinoma to thyroid gland is very rare and usually associated with other distal metastasis. This report describes for the first time isolated multiple bilateral thyroid metastasis from prostatic adenocarcinoma. A 67-year-old man who is known as a case of prostatic adenocarcinoma...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9232-4
更新日期:2013-03-01 00:00:00
abstract::The history of pituitary pathology is a long one that dates back to biblical times, but the last 25 years have represented an era of "coming of age." The role of the pituitary in health and disease was the subject of many studies over the last century. With the development of electron microscopy, immunoassays, and imm...
journal_title:Endocrine pathology
pub_type: 历史文章,杂志文章
doi:10.1007/s12022-013-9284-5
更新日期:2014-03-01 00:00:00
abstract::To assess the proliferative activity of pituitary adenomas, 36 surgically removed adenomas were studied by light microscopical parameters; mitotic count; expression of PCNA, Ki-67, cathepsin D, and EGF; and image cytometry. Three adenomas (9%) showed high, 11 (34%) medium, 17 (53%) moderate, and 1 (3%) low structural ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921487
更新日期:1994-12-01 00:00:00
abstract::We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be mor...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9575-6
更新日期:2019-06-01 00:00:00
abstract::Efforts to understand the pathobiology of pheochromocytomas and extra-adrenal paragangliomas have been spurred by genetic and gene expression profiling studies showing genotype-phenotype correlations in familial pheochromocytoma/paraganglioma syndromes and in some sporadic tumors. The current challenge is to relate ca...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-006-0003-3
更新日期:2006-01-01 00:00:00
abstract::Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. T...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738793
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:4:331
更新日期:2005-01-01 00:00:00
abstract::Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on ...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-020-09638-x
更新日期:2020-09-01 00:00:00
abstract::The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9577-4
更新日期:2019-06-01 00:00:00
abstract::Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:17:1:53
更新日期:2006-04-01 00:00:00
abstract::Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the ...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-010-9113-z
更新日期:2010-06-01 00:00:00
abstract::The incidence and histology of cysts in the adenohypophysis of adult male Wistar rats are reported. Of sixty pituitaries studied 13 of them (21.6%) presented a single cyst located in the pars distalis. The cysts varied in shape and size and were usually multilocular. Two of them were connected with the subdural space ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:1:63
更新日期:2001-04-01 00:00:00
abstract::Pleomorphic leiomyosarcoma (PLMS) of the adrenal gland is a rare tumor in an unusual location. A primary PLMS of the left adrenal gland is reported in a 59-yr-old Mexican woman who presented progressive flank pain and weight loss. The tumor measured 16 cm in diameter, showed markedly pleomorphic and osteoclast-like gi...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:1:075
更新日期:2005-04-01 00:00:00
abstract::Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9559-y
更新日期:2019-03-01 00:00:00
abstract::Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9024-4
更新日期:2008-10-01 00:00:00
abstract::The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9014-6
更新日期:2008-04-01 00:00:00
abstract::Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739931
更新日期:1997-01-01 00:00:00
abstract::Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:3:173
更新日期:2005-10-01 00:00:00
abstract::In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9263-x
更新日期:2013-12-01 00:00:00
abstract::Recent advances in molecular pathology have shed light not only on the cellular composition and derivation of various tumors, but also on their growth potential, likelihood of recurrence, and prognosis. The development of reliable and prognostically informative methods of assessing tumor behavior is particularly impor...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:16:1:001
更新日期:2005-04-01 00:00:00