Abstract：
:Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on growth patterns including thyroid neoplasms with predominantly papillary, follicular, solid, and spindle cell growth pattern, as well as neoplasms with distinct cytological characteristics. A special section is also dedicated to rare thyroid tumors with peculiar patterns including thyroid carcinoma with Ewing family tumor elements and intrathyroidal thymic-related neoplasms.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Cameselle-Teijeiro JM,Eloy C,Sobrinho-Simões Mdoi
10.1007/s12022-020-09638-xsubject
Has Abstractpub_date
2020-09-01 00:00:00pages
197-217issue
3eissn
1046-3976issn
1559-0097pii
10.1007/s12022-020-09638-xjournal_volume
31pub_type
杂志文章,评审abstract：:In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-013-9263-x
更新日期：2013-12-01 00:00:00
abstract：:The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915332
更新日期：1991-06-01 00:00:00
abstract：:Synchronous occurrence of medullary and papillary carcinoma of the thyroid gland is very rare. We describe two cases of synchronous medullary and papillary carcinoma of the thyroid. In both cases, medullary carcinoma and papillary carcinoma were separate in the thyroid but mixed in some of the lymph node metastases. A...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:1:83
更新日期：2004-04-01 00:00:00
abstract：:Goblet cell carcinoid (GCC) of the appendix is a rare entity, of which both the histogenesis and biologic behavior remain controversial, and prognostic tools and therapeutic strategies for this unusual tumor have yet to be defined. The aim of this study was to analyze expression of E-cadherin and b-catenin in GCCs of ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:13:1:47
更新日期：2002-04-01 00:00:00
abstract：:Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:4:351
更新日期：2004-01-01 00:00:00
abstract：:Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:2:107
更新日期：2003-07-01 00:00:00
abstract：:Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9422-y
更新日期：2016-12-01 00:00:00
abstract：:Non-coding (nc)RNAs are divided into small ncRNAs and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are small ncRNAS which are around 22 nucleotides in length that mediate post-transcriptional gene silencing. LncRNAs are greater than 200 bp in length. Each ncRNA can have multiple targets and can be regulated by multiple g...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-016-9417-8
更新日期：2016-03-01 00:00:00
abstract：:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9420-0
更新日期：2016-06-01 00:00:00
abstract：:Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACT...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-012-9197-8
更新日期：2012-06-01 00:00:00
abstract：:The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-015-9401-8
更新日期：2015-12-01 00:00:00
abstract：:Granular cell tumours of the thyroid gland are rare, with only six previously reported cases in the English literature. Current histological, immunohistochemical and electron microscopic evidence favours a neural/Schwannian relationship. A case of a granular cell tumour of the thyroid gland in a healthy 36-year-old wo...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-011-9146-y
更新日期：2011-03-01 00:00:00
abstract：:Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. Th...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-009-9079-x
更新日期：2009-10-01 00:00:00
abstract：:There is evidence that programmed death-ligand 1 (PD-L1) is expressed by thyroid follicular epithelium in thyroiditis, but the role of PD-L1 in papillary thyroid carcinoma (PTC) is poorly understood. We aimed to determine whether (1) the presence of background chronic lymphocytic thyroiditis (CLT) or Hashimoto thyroid...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9540-9
更新日期：2018-12-01 00:00:00
abstract：:Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739931
更新日期：1997-01-01 00:00:00
abstract：:Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-009-9087-x
更新日期：2009-01-01 00:00:00
abstract：:We report a very rare case of Cushing's syndrome caused by an ileal adrenocorticotrophin-secreting well-differentiated endocrine carcinoma with liver metastases. A 62-yr-old woman presented with clinical and biological signs suggestive of paraneoplastic Cushing's syndrome Radiological investigations, including magneti...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:11:4:359
更新日期：2000-01-01 00:00:00
abstract：:Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915325
更新日期：1991-03-01 00:00:00
abstract：:Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. T...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02738793
更新日期：1997-10-01 00:00:00
abstract：:Transcription factors play specific roles in the development and differentiation of normal pituitary tissues and pituitary adenoma. The transcription factor, muscle segment homeobox 1 (MSX1), which belongs to the homeobox gene family, binds the promoter region of the glycoprotein hormone alpha-subunit (SU) in TSH-prod...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9021-7
更新日期：2008-04-01 00:00:00
abstract：:Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9518-7
更新日期：2018-03-01 00:00:00
abstract：:Neuroendocrine secretory protein-55 (NESP-55) is a recently described member of the chromogranin family and appears to be a marker of the constitutive secretory pathway in certain neural, neuroendocrine, and endocrine cell types. It has been shown to be selectively expressed in tumors differentiating towards the adren...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-011-9162-y
更新日期：2011-09-01 00:00:00
abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-013-9240-4
更新日期：2013-06-01 00:00:00
abstract：:Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recent...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9557-0
更新日期：2019-03-01 00:00:00
abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9433-8
更新日期：2016-09-01 00:00:00
abstract：:Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9024-4
更新日期：2008-10-01 00:00:00
abstract：:The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9014-6
更新日期：2008-04-01 00:00:00
abstract：:Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-014-9333-8
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-003-0017-z
更新日期：2003-10-01 00:00:00
abstract：:Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915452
更新日期：1991-09-01 00:00:00
