Abstract：
:Non-coding (nc)RNAs are divided into small ncRNAs and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are small ncRNAS which are around 22 nucleotides in length that mediate post-transcriptional gene silencing. LncRNAs are greater than 200 bp in length. Each ncRNA can have multiple targets and can be regulated by multiple genetic factors. Because ncRNAs are not translated into proteins, they can only be detected at the nucleic acid level by in situ hybridization, by RT-PCR, or by sequencing which makes their detection more challenging in the routine pathology laboratory. A great deal of new information has accumulated about miRNAs in thyroid tissues during the past decade. Some of these studies have shown that deregulation of miRNAs may be useful in diagnostic pathology. Information about the role of lncRNA in the development of thyroid tumors is in the early stages of development, but new information is accumulating rapidly. In this review, we will discuss the recent progress in our understanding of the relationship between ncRNAs and the development of thyroid cancers and the potential uses of ncRNAs in the diagnosis and prognosis of thyroid tumors.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Zhang R,Hardin H,Chen J,Guo Z,Lloyd RVdoi
10.1007/s12022-016-9417-8subject
Has Abstractpub_date
2016-03-01 00:00:00pages
12-20issue
1eissn
1046-3976issn
1559-0097pii
10.1007/s12022-016-9417-8journal_volume
27pub_type
杂志文章,评审abstract：:Alterations of the von Hippel-Lindau (VHL) gene, which is supposed to act as a tumor suppressor gene, can cause hereditary tumors associated with the VHL syndrome and are found in different sporadic cancers as well. While VHL protein is distinctly detectable in thyroid follicles, so far its expression in nonneoplastic...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:11:2:145
更新日期：2000-07-01 00:00:00
abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-007-9002-2
更新日期：2008-04-01 00:00:00
abstract：:Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915325
更新日期：1991-03-01 00:00:00
abstract：:The recent increase in the detection of papillary thyroid carcinoma (PTC) has been influenced by the finding of incidental tumours. To this group, carcinomas measuring less than 1 cm (the so-called microcarcinomas) as well as those above 1 cm belong. Analyzing a case series from our own experience, this paper focuses ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-014-9323-x
更新日期：2014-09-01 00:00:00
abstract：:Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cell...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915304
更新日期：1993-09-01 00:00:00
abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739915
更新日期：1996-04-01 00:00:00
abstract：:Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the ...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-010-9113-z
更新日期：2010-06-01 00:00:00
abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:15:3:241
更新日期：2004-10-01 00:00:00
abstract：:Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9422-y
更新日期：2016-12-01 00:00:00
abstract：:Aldosterone-producing adenoma (APA) consisting of pure zona glomerulosa (ZG)-type cells is extremely rare, and primary aldosteronism complicated by pregnancy is also rare. We report a case of APA discovered in a 32-year-old pregnant woman who visited our hospital for hypertension and hypokalemia at 26 weeks gestation....
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-009-9060-8
更新日期：2009-04-01 00:00:00
abstract：:Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02914490
更新日期：1993-03-01 00:00:00
abstract：:A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:2:141
更新日期：2004-07-01 00:00:00
abstract：:The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-020-09630-5
更新日期：2020-09-01 00:00:00
abstract：:Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02914989
更新日期：1995-04-01 00:00:00
abstract：:The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:13:4:321
更新日期：2002-01-01 00:00:00
abstract：:Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:2:107
更新日期：2003-07-01 00:00:00
abstract：:Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9549-0
更新日期：2018-12-01 00:00:00
abstract：:Crohn's disease is one of the causes of secondary amyloidosis, which can lead to amyloid infiltration of the thyroid gland. It is essential to follow strict controls to prevent the appearance of a large amyloid goiter. Two patients with amyloid goiter secondary to Crohn's disease, with a large adipose tissue component...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-012-9220-0
更新日期：2012-12-01 00:00:00
abstract：:A case of localized adiposity of the thyroid in a 35-year-old woman with a long history of steroid therapy for nephrotic syndrome is reported. A well-demarcated yellowish mass measuring 2 cm in diameter was found in the upper portion of the right lobe of the thyroid. Microscopically, this lesion was composed of mature...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915212
更新日期：1991-12-01 00:00:00
abstract：:We report a very rare case of Cushing's syndrome caused by an ileal adrenocorticotrophin-secreting well-differentiated endocrine carcinoma with liver metastases. A 62-yr-old woman presented with clinical and biological signs suggestive of paraneoplastic Cushing's syndrome Radiological investigations, including magneti...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:11:4:359
更新日期：2000-01-01 00:00:00
abstract：:Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on ...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-020-09638-x
更新日期：2020-09-01 00:00:00
abstract：:We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9464-1
更新日期：2017-12-01 00:00:00
abstract：:A cell fine of human medullary carcinoma of the thyroid, abundantly producing calcitonin (Ct) and related hormones, has proved remarkably useful as an endocrine tumor model for the study of the secretion mechanism. This cell line (TT cell) was used in studies to elucidate the dynamics of the release of Ct and chromogr...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915322
更新日期：1991-03-01 00:00:00
abstract：:Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739692
更新日期：1998-01-01 00:00:00
abstract：:The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02738728
更新日期：1995-01-01 00:00:00
abstract：:In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739828
更新日期：1999-06-01 00:00:00
abstract：:Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9471-x
更新日期：2017-03-01 00:00:00
abstract：:Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:16:3:173
更新日期：2005-10-01 00:00:00
abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9466-z
更新日期：2017-03-01 00:00:00
abstract：:The incidence and histology of cysts in the adenohypophysis of adult male Wistar rats are reported. Of sixty pituitaries studied 13 of them (21.6%) presented a single cyst located in the pars distalis. The cysts varied in shape and size and were usually multilocular. Two of them were connected with the subdural space ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:12:1:63
更新日期：2001-04-01 00:00:00
