TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway.

abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...

journal_title：Endocrine pathology

authors： Hellman P,Bjerneroth G,Juhlin C,Ridefelt P,Rastad J,Åkerström G,Jüppner H

更新日期：1990-09-01 00:00:00

abstract：:Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In add...

journal_title：Endocrine pathology

authors： La Rosa S,Bernasconi B,Micello D,Finzi G,Capella C

更新日期：2009-04-01 00:00:00

abstract：:Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...

journal_title：Endocrine pathology

authors： Fraune C,Simon R,Hube-Magg C,Makrypidi-Fraune G,Kluth M,Büscheck F,Amin T,Viol F,Fehrle W,Dum D,Höflmayer D,Burandt E,Clauditz TS,Perez D,Izbicki J,Wilczak W,Sauter G,Steurer S,Schrader J

更新日期：2020-06-01 00:00:00

abstract：:The BRAF(V600E) mutation is specific for thyroid papillary cancer (PTC) and correlates with PTCs invasiveness. This study investigated whether detection of BRAF(V600E) mutation can be performed on routinely stained FNABs. We also examined if establishment of the BRAF(V600E) mutation could help in identification of pat...

journal_title：Endocrine pathology

authors： Patel A,Klubo-Gwiezdzinska J,Hoperia V,Larin A,Jensen K,Bauer A,Vasko V

更新日期：2011-12-01 00:00:00

abstract：:A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...

journal_title：Endocrine pathology

authors： Chetty R,Kennedy M,Ezzat S,Asa SL

更新日期：2004-07-01 00:00:00

abstract：:Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medul...

journal_title：Endocrine pathology

authors： Albores-Saavedra JA,Krueger JE

更新日期：2001-01-01 00:00:00

abstract：:Aldosterone-producing adenoma (APA) consisting of pure zona glomerulosa (ZG)-type cells is extremely rare, and primary aldosteronism complicated by pregnancy is also rare. We report a case of APA discovered in a 32-year-old pregnant woman who visited our hospital for hypertension and hypokalemia at 26 weeks gestation....

journal_title：Endocrine pathology

authors： Shigematsu K,Nishida N,Sakai H,Igawa T,Suzuki S,Kawai K,Takahara O

更新日期：2009-04-01 00:00:00

abstract：:Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...

journal_title：Endocrine pathology

authors： Jug R,Parajuli S,Ahmadi S,Jiang XS

更新日期：2019-06-01 00:00:00

abstract：:Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8...

journal_title：Endocrine pathology

authors： Beckers A,Kovacs K,Horvath E,Abs R,Reznik M,Stevenaert A

更新日期：1991-09-01 00:00:00

abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...

journal_title：Endocrine pathology

authors： Abbona G,Papotti M,Gasparri G,Bussolati G

更新日期：1996-04-01 00:00:00

abstract：:A case of localized adiposity of the thyroid in a 35-year-old woman with a long history of steroid therapy for nephrotic syndrome is reported. A well-demarcated yellowish mass measuring 2 cm in diameter was found in the upper portion of the right lobe of the thyroid. Microscopically, this lesion was composed of mature...

journal_title：Endocrine pathology

authors： Morizumi H,Sano T,Tsuyuguchi M,Yoshinarl T,Morimoto S

更新日期：1991-12-01 00:00:00

abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...

journal_title：Endocrine pathology

authors： Gucer H,Bagci P,Bedir R,Sehitoglu I,Mete O

更新日期：2016-09-01 00:00:00

abstract：:The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...

journal_title：Endocrine pathology

authors： Lloyd RV,Carney JA,Ferreiro JA,Jin L,Thompson GB,Van Heerden JA,Grant CS,Wollan PC

更新日期：1995-01-01 00:00:00

abstract：:In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...

journal_title：Endocrine pathology

authors： Booth GL,Smyth HS,Kovacs K,Horvath E,Asa SL,Ezzat S

更新日期：1999-06-01 00:00:00

abstract：:Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human br...

journal_title：Endocrine pathology

authors： Pilichowska M,Kimura N,Schindler M,Suzuki A,Yoshida R,Nagura H

更新日期：2000-04-01 00:00:00

abstract：:A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneo...

journal_title：Endocrine pathology

authors： Lin J,Wasco MJ,Korobkin M,Doherty G,Giordano TJ

更新日期：2007-01-01 00:00:00

abstract：:In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...

journal_title：Endocrine pathology

authors： Fonseca E,Castanhas S,Sobrinho-Simoes M

更新日期：1996-01-01 00:00:00

abstract：:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...

journal_title：Endocrine pathology

authors： Raphael SL,Asa SL

更新日期：1995-10-01 00:00:00

abstract：:Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...

journal_title：Endocrine pathology

authors： Sargent R,LiVolsi V,Murphy J,Mantha G,Hunt JL

更新日期：2006-10-01 00:00:00

abstract：:We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis. The patient was diagnosed with breast cancer and received chemotherapy 3 years before parathyroidectomy. The question can be raised whether chemotherapeutic agents may damage pa...

journal_title：Endocrine pathology

authors： Kovacs K,Bell CD,Juco J,Rotondo F,Anderson J

更新日期：2007-04-01 00:00:00

abstract：:The adrenal gland is the body's primary source for epinephrine production and release, and the chromaffin cells that comprise the adrenal medulla possess all of the catecholamine biosynthetic machinery, including phenylethanolamine N-methyltransferase (PNMT), the enzyme synthesizing epinephrine from norepinephrine. In...

journal_title：Endocrine pathology

authors： Wong DL

更新日期：2003-04-01 00:00:00

abstract：:High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...

journal_title：Endocrine pathology

authors： Gupta S,Sahu D,Bomalaski JS,Frank I,Boorjian SA,Thapa P,Cheville JC,Hansel DE

更新日期：2018-09-01 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...

journal_title：Endocrine pathology

authors： Akbulut D,Kuz ED,Kursun N,Dizbay Sak S

更新日期：2021-01-04 00:00:00

abstract：:Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...

journal_title：Endocrine pathology

authors： Satoh F,Umemura S,Yasuda M,Osamura RY

更新日期：2001-10-01 00:00:00

abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...

journal_title：Endocrine pathology

authors： Nosé V,Volante M,Papotti M

更新日期：2008-04-01 00:00:00

abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...

journal_title：Endocrine pathology

authors： Crescenzi A,Fulciniti F,Bongiovanni M,Giovanella L,Trimboli P

更新日期：2017-03-01 00:00:00

abstract：:The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less t...

journal_title：Endocrine pathology

authors： Glomski K,Nosé V,Faquin WC,Sadow PM

更新日期：2017-06-01 00:00:00

abstract：:The incidence and histology of cysts in the adenohypophysis of adult male Wistar rats are reported. Of sixty pituitaries studied 13 of them (21.6%) presented a single cyst located in the pars distalis. The cysts varied in shape and size and were usually multilocular. Two of them were connected with the subdural space ...

journal_title：Endocrine pathology

authors： Quintanar-Stephano A,Muñoz Fernández L,Quintanar JL,Kovacs K

更新日期：2001-04-01 00:00:00

abstract：:The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...

journal_title：Endocrine pathology

authors： Chung SR,Baek JH,Lee JH,Lee YM,Sung TY,Chung KW,Hong SJ,Jeon MJ,Kim TY,Shong YK,Kim WB,Kim WG,Song DE

更新日期：2019-06-01 00:00:00

abstract：:Hypophysitis is an inflammatory disease of the pituitary gland that clinically and radiologically mimics pituitary tumors. We report here a case of xanthogranulomatous hypophysitis mimicking a pituitary neoplasm.A 65-yr-old woman presented with weight loss, fatigue, and visual disturbance. Computed tomography demonstr...

journal_title：Endocrine pathology

authors： Yokoyama S,Sano T,Tajitsu K,Kusumoto K

更新日期：2004-01-01 00:00:00