Neuroendocrine marker expression in thyroid epithelial tumors.

abstract：:The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...

journal_title：Endocrine pathology

authors： Hunt JL,Baloch ZW,Barnes L,Swalsky PA,Trusky CL,Sesatomi E,Finkelstein S,LiVolsi VA

更新日期：2002-01-01 00:00:00

abstract：:Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin- and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report the first case of an association between craniopharyngioma ...

journal_title：Endocrine pathology

authors： Moshkin O,Scheithauer BW,Syro LV,Velasquez A,Horvath E,Kovacs K

更新日期：2009-04-01 00:00:00

abstract：:In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...

journal_title：Endocrine pathology

authors： Lee SH,Baek JS,Lee JY,Lim JA,Cho SY,Lee TH,Ku YH,Kim HI,Kim MJ

更新日期：2013-12-01 00:00:00

abstract：:Hurthle cell carcinoma of the thyroid is generally considered to be a subtype of follicular carcinoma. We report a case of a small solitary usual-type papillary carcinoma of the thyroid, with metastatic tumor in cervical lymph nodes. The lymph node tumor consisted of both tall-cell papillary carcinoma and Hurthle cell...

journal_title：Endocrine pathology

authors： Zwi LJ,LiVolsi VA

更新日期：2002-10-01 00:00:00

abstract：:Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...

journal_title：Endocrine pathology

authors： Sargent R,LiVolsi V,Murphy J,Mantha G,Hunt JL

更新日期：2006-10-01 00:00:00

abstract：:Solitary metastasis from prostate adenocarcinoma to thyroid gland is very rare and usually associated with other distal metastasis. This report describes for the first time isolated multiple bilateral thyroid metastasis from prostatic adenocarcinoma. A 67-year-old man who is known as a case of prostatic adenocarcinoma...

journal_title：Endocrine pathology

authors： Albsoul NM,Obeidat FN,Hadidy AM,Alzoubi MN,Taib AA,Shahait AD

更新日期：2013-03-01 00:00:00

abstract：:To assess the proliferative activity of pituitary adenomas, 36 surgically removed adenomas were studied by light microscopical parameters; mitotic count; expression of PCNA, Ki-67, cathepsin D, and EGF; and image cytometry. Three adenomas (9%) showed high, 11 (34%) medium, 17 (53%) moderate, and 1 (3%) low structural ...

journal_title：Endocrine pathology

authors： Krämer A,Saeger W,Tallen G,Lüdecke DK

更新日期：1994-12-01 00:00:00

abstract：:We report clinicopathological features of a large series of synchronous multiple pituitary neuroendocrine tumors (PitNETs) of different cell lineages. Retrospective review of pathology records from 2001 to 2016 identified 13 synchronous multiple PitNETs from 1055 PitNETs classified using pituitary cell-lineage transcr...

journal_title：Endocrine pathology

authors： Mete O,Alshaikh OM,Cintosun A,Ezzat S,Asa SL

更新日期：2018-12-01 00:00:00

abstract：:Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid ca...

journal_title：Endocrine pathology

authors： Cassol CA,Guo M,Ezzat S,Asa SL

更新日期：2010-12-01 00:00:00

abstract：:Efforts to understand the pathobiology of pheochromocytomas and extra-adrenal paragangliomas have been spurred by genetic and gene expression profiling studies showing genotype-phenotype correlations in familial pheochromocytoma/paraganglioma syndromes and in some sporadic tumors. The current challenge is to relate ca...

journal_title：Endocrine pathology

authors： Tischler AS

更新日期：2006-01-01 00:00:00

abstract：:The BRAF(V600E) mutation is specific for thyroid papillary cancer (PTC) and correlates with PTCs invasiveness. This study investigated whether detection of BRAF(V600E) mutation can be performed on routinely stained FNABs. We also examined if establishment of the BRAF(V600E) mutation could help in identification of pat...

journal_title：Endocrine pathology

authors： Patel A,Klubo-Gwiezdzinska J,Hoperia V,Larin A,Jensen K,Bauer A,Vasko V

更新日期：2011-12-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...

journal_title：Endocrine pathology

authors： Yokoyama S,Stefaneanu L,Kovacs K

更新日期：1997-10-01 00:00:00

abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...

journal_title：Endocrine pathology

authors： Crescenzi A,Fulciniti F,Bongiovanni M,Giovanella L,Trimboli P

更新日期：2017-03-01 00:00:00

abstract：:Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...

journal_title：Endocrine pathology

authors： Stilling GA,Bayliss JM,Jin L,Zhang H,Lloyd RV

更新日期：2005-10-01 00:00:00

abstract：:Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACT...

journal_title：Endocrine pathology

authors： Formosa R,Gruppetta M,Falzon S,Santillo G,DeGaetano J,Xuereb-Anastasi A,Vassallo J

更新日期：2012-06-01 00:00:00

abstract：:Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8...

journal_title：Endocrine pathology

authors： Beckers A,Kovacs K,Horvath E,Abs R,Reznik M,Stevenaert A

更新日期：1991-09-01 00:00:00

abstract：:Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...

journal_title：Endocrine pathology

authors： Jug R,Parajuli S,Ahmadi S,Jiang XS

更新日期：2019-06-01 00:00:00

abstract：:Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...

journal_title：Endocrine pathology

authors： Pilichowska M,Kimura N,Schindler M,Kobari M

更新日期：2001-07-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00

abstract：:Neuroendocrine secretory protein-55 (NESP-55) is a recently described member of the chromogranin family and appears to be a marker of the constitutive secretory pathway in certain neural, neuroendocrine, and endocrine cell types. It has been shown to be selectively expressed in tumors differentiating towards the adren...

journal_title：Endocrine pathology

authors： Gupta M,Lloyd RV,Fischer-Colbrie R,Tischler AS,Dayal Y

更新日期：2011-09-01 00:00:00

abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...

journal_title：Endocrine pathology

authors： Gucer H,Bagci P,Bedir R,Sehitoglu I,Mete O

更新日期：2016-09-01 00:00:00

abstract：:Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...

journal_title：Endocrine pathology

authors： Shan L,Iwasaki A,Utsunomiya H,Kawano I,Matsuura N,Kobayashi A,Kuma K,Kakudo K

更新日期：1995-07-01 00:00:00

abstract：:In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...

journal_title：Endocrine pathology

authors： Booth GL,Smyth HS,Kovacs K,Horvath E,Asa SL,Ezzat S

更新日期：1999-06-01 00:00:00

abstract：:The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...

journal_title：Endocrine pathology

authors： Marin F,Kovacs K,Stefaneanu L,Horvath E,Cheng Z

更新日期：1992-03-01 00:00:00

abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...

journal_title：Endocrine pathology

authors： Hellman P,Bjerneroth G,Juhlin C,Ridefelt P,Rastad J,Åkerström G,Jüppner H

更新日期：1990-09-01 00:00:00

abstract：:A case of localized adiposity of the thyroid in a 35-year-old woman with a long history of steroid therapy for nephrotic syndrome is reported. A well-demarcated yellowish mass measuring 2 cm in diameter was found in the upper portion of the right lobe of the thyroid. Microscopically, this lesion was composed of mature...

journal_title：Endocrine pathology

authors： Morizumi H,Sano T,Tsuyuguchi M,Yoshinarl T,Morimoto S

更新日期：1991-12-01 00:00:00

abstract：:Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...

journal_title：Endocrine pathology

authors： Giordano TJ

更新日期：2003-07-01 00:00:00

abstract：:Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...

journal_title：Endocrine pathology

authors： Lubensky IA,Zhuang Z

更新日期：2007-10-01 00:00:00

abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...

journal_title：Endocrine pathology

authors： Rego KG,Billerbeck AE,Targovnik HM,Santos CL,Alkmin MG,Barbosa S,Camargo R,Medeiros-Neto G

更新日期：1997-04-01 00:00:00

abstract：:This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...

journal_title：Endocrine pathology

authors： Onder S,Ozturk Sari S,Yegen G,Sormaz IC,Yilmaz I,Poyrazoglu S,Sanlı Y,Giles Senyurek Y,Kapran Y,Mete O

更新日期：2016-06-01 00:00:00