Abstract:
:To assess the proliferative activity of pituitary adenomas, 36 surgically removed adenomas were studied by light microscopical parameters; mitotic count; expression of PCNA, Ki-67, cathepsin D, and EGF; and image cytometry. Three adenomas (9%) showed high, 11 (34%) medium, 17 (53%) moderate, and 1 (3%) low structural differentiation. In 10 adenomas (31%), no mitosis was observed. The average was 2.4 mitoses/100 HPF; the highest count was 7.1 mitoses/100 HPF. Eleven adenomas (33.3%) were PCNA-negative; in 20 adenomas (60.6%), between 0.05 and 3.9, and in 2 adenomas (6.0%), between 10.5 and 16.4 PCNA-positive nuclei were observed. Only a recurrent null-cell adenoma (9%) was Ki-67-negative. Three adenomas (9.1%) were EGF-negative, 28 (84.8%) showed up to 10% positive cells, and 2 (6.1 %) showed between 10 and 30% positive cells; 19 adenomas (68%) were cathepsin D-negative, including all endocrine-inactive adenomas. Half the adenomas had an euploid DMA stem line. Endocrine-inactive adenomas displayed a higher rate of euploid DNA stem lines than endocrine-active adenomas. The S-phase fraction varied between 2.97 and 28%, with a mean value of 14.4%. Half the adenomas showed an S-phase fraction of 11.65% or lower.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Krämer A,Saeger W,Tallen G,Lüdecke DKdoi
10.1007/BF02921487subject
Has Abstractpub_date
1994-12-01 00:00:00pages
198-211issue
4eissn
1046-3976issn
1559-0097pii
10.1007/BF02921487journal_volume
5pub_type
杂志文章abstract::Using conventional histological technique, we investigated 44 adenomas (31 men, 13 women) incidentally found in 36 pituitaries (25 men, 11 women) obtained from 1,117 unselected autopsies. The overall incidence of adenomas was 3.2% (men, 3.8%; women, 2.4%) without any significant sex predominance. Size, age distributio...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921376
更新日期:1994-06-01 00:00:00
abstract::Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915452
更新日期:1991-09-01 00:00:00
abstract::We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis. The patient was diagnosed with breast cancer and received chemotherapy 3 years before parathyroidectomy. The question can be raised whether chemotherapeutic agents may damage pa...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-0001-0
更新日期:2007-04-01 00:00:00
abstract::Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human br...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:11:1:57
更新日期:2000-04-01 00:00:00
abstract::Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9333-8
更新日期:2014-12-01 00:00:00
abstract::Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9422-y
更新日期:2016-12-01 00:00:00
abstract::The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9014-6
更新日期:2008-04-01 00:00:00
abstract::The incidence and histology of cysts in the adenohypophysis of adult male Wistar rats are reported. Of sixty pituitaries studied 13 of them (21.6%) presented a single cyst located in the pars distalis. The cysts varied in shape and size and were usually multilocular. Two of them were connected with the subdural space ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:1:63
更新日期:2001-04-01 00:00:00
abstract::Granular cell tumours of the thyroid gland are rare, with only six previously reported cases in the English literature. Current histological, immunohistochemical and electron microscopic evidence favours a neural/Schwannian relationship. A case of a granular cell tumour of the thyroid gland in a healthy 36-year-old wo...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-011-9146-y
更新日期:2011-03-01 00:00:00
abstract::There is evidence that programmed death-ligand 1 (PD-L1) is expressed by thyroid follicular epithelium in thyroiditis, but the role of PD-L1 in papillary thyroid carcinoma (PTC) is poorly understood. We aimed to determine whether (1) the presence of background chronic lymphocytic thyroiditis (CLT) or Hashimoto thyroid...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9540-9
更新日期:2018-12-01 00:00:00
abstract::In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739836
更新日期:1996-01-01 00:00:00
abstract::The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9577-4
更新日期:2019-06-01 00:00:00
abstract::A case of ectopic thymic tissue of the thyroid in a 30-year-old woman with Graves' disease is reported. The thyroidectomy specimen, removed because of failure of medical therapy, showed a continuous track of thymic tissue extending from the center of the gland to the capsule along an interiobular septum. This finding ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915305
更新日期:1993-09-01 00:00:00
abstract::Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:3:291
更新日期:2001-10-01 00:00:00
abstract::Recent advances in molecular pathology have shed light not only on the cellular composition and derivation of various tumors, but also on their growth potential, likelihood of recurrence, and prognosis. The development of reliable and prognostically informative methods of assessing tumor behavior is particularly impor...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:16:1:001
更新日期:2005-04-01 00:00:00
abstract::The adrenal gland is the body's primary source for epinephrine production and release, and the chromaffin cells that comprise the adrenal medulla possess all of the catecholamine biosynthetic machinery, including phenylethanolamine N-methyltransferase (PNMT), the enzyme synthesizing epinephrine from norepinephrine. In...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:1:25
更新日期:2003-04-01 00:00:00
abstract::Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medul...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:12:4:365
更新日期:2001-01-01 00:00:00
abstract::Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9559-y
更新日期:2019-03-01 00:00:00
abstract::Pheochromocytomas and paragangliomas are neuroendocrine neoplasias of neural crest origin. Genetic mutations that are characterized in other human neoplasms are rarely seen in these tumors. About 10% of the patients with pheochromocytomas and paragangliomas present with a family history of von Hippel-Lindau disease (V...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:4:329
更新日期:2003-01-01 00:00:00
abstract::Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-007-9007-x
更新日期:2007-10-01 00:00:00
abstract::Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid ca...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-010-9129-4
更新日期:2010-12-01 00:00:00
abstract::Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02914989
更新日期:1995-04-01 00:00:00
abstract::Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping. At the molecular level, the association between CLT and PTC is...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:17:3:235
更新日期:2006-10-01 00:00:00
abstract::Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin- and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report the first case of an association between craniopharyngioma ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9065-3
更新日期:2009-04-01 00:00:00
abstract::Hurthle cell carcinoma of the thyroid is generally considered to be a subtype of follicular carcinoma. We report a case of a small solitary usual-type papillary carcinoma of the thyroid, with metastatic tumor in cervical lymph nodes. The lymph node tumor consisted of both tall-cell papillary carcinoma and Hurthle cell...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-002-0002-y
更新日期:2002-10-01 00:00:00
abstract::Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9024-4
更新日期:2008-10-01 00:00:00
abstract::Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cell...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915304
更新日期:1993-09-01 00:00:00
abstract::Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9087-x
更新日期:2009-01-01 00:00:00
abstract::This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9420-0
更新日期:2016-06-01 00:00:00
abstract::Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9518-7
更新日期:2018-03-01 00:00:00