Prognostic indicators in pituitary tumors.

abstract：:Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...

journal_title：Endocrine pathology

authors： Satoh F,Umemura S,Yasuda M,Osamura RY

更新日期：2001-10-01 00:00:00

abstract：:Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...

journal_title：Endocrine pathology

authors： Lubensky IA,Zhuang Z

更新日期：2007-10-01 00:00:00

abstract：:A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...

journal_title：Endocrine pathology

authors： Chetty R,Kennedy M,Ezzat S,Asa SL

更新日期：2004-07-01 00:00:00

abstract：:We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...

journal_title：Endocrine pathology

authors： Rotondo F,Qaddoura A,Syro LV,Karamchandani J,Munoz DG,Arroyave MJ,Ospina WP,Cusimano MD,Kovacs K

更新日期：2017-12-01 00:00:00

abstract：:A case of pancreatic acinar cell tumor (ACC) is presented in a 10-year-old boy. The tumor manifested clinically with Cushing's syndrome, high serum adrenocorticotropic hormone (ACTH) and cortisol concentrations. In addition, excessive serum levels of alpha-fetoprotein (AFP) were detected. Surgical resection was not po...

journal_title：Endocrine pathology

authors： Illyés G,Luczay A,Benyó G,Kálmán A,Borka K,Köves K,Rácz K,Tulassay T,Schaff Z

更新日期：2007-07-01 00:00:00

abstract：:Objective. Information on angiogenesis in parathyroid pathology is scanty and in particular no data are available in parathyroid carcinomas. The aim of this study was to analyze angiogenesis as microvascular density (MVD) in parathyroid neoplastic progression from normal gland to adenoma and carcinoma. Methods. Sectio...

journal_title：Endocrine pathology

authors： Viacava P,Bocci G,Fanelli G,Cetani F,Marcocci C,Bevilacqua G,Naccarato AG

更新日期：2006-07-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00

abstract：:The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...

journal_title：Endocrine pathology

authors： Suzuki M,Egashira N,Kajiya H,Minematsu T,Takekoshi S,Tahara S,Sanno N,Teramoto A,Osamura RY

更新日期：2008-04-01 00:00:00

abstract：:We report a very rare case of Cushing's syndrome caused by an ileal adrenocorticotrophin-secreting well-differentiated endocrine carcinoma with liver metastases. A 62-yr-old woman presented with clinical and biological signs suggestive of paraneoplastic Cushing's syndrome Radiological investigations, including magneti...

journal_title：Endocrine pathology

authors： Valo I,Rohmer V,Guyetant S,Martin JF,Venault S,Saint-Andre JP

更新日期：2000-01-01 00:00:00

abstract：:The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...

journal_title：Endocrine pathology

authors： Franscella S,Favrod-Coune CA,Pizzolato G,Asa SL,Gaillard R,Berney J,Philippe J

更新日期：1991-06-01 00:00:00

abstract：:Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medul...

journal_title：Endocrine pathology

authors： Albores-Saavedra JA,Krueger JE

更新日期：2001-01-01 00:00:00

abstract：:Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic...

journal_title：Endocrine pathology

authors： Yu J,Nikiforova MN,Hodak SP,Yim JH,Cai G,Walls A,Nikiforov YE,Seethala RR

更新日期：2009-01-01 00:00:00

abstract：:Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...

journal_title：Endocrine pathology

authors： Zheng Z,Zhou X,Cai Y,Chen E,Zhang X,Wang O,Wang Q,Liu H

更新日期：2018-12-01 00:00:00

abstract：:The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...

journal_title：Endocrine pathology

authors： Marin F,Kovacs K,Stefaneanu L,Horvath E,Cheng Z

更新日期：1992-03-01 00:00:00

abstract：:The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...

journal_title：Endocrine pathology

authors： Chung SR,Baek JH,Lee JH,Lee YM,Sung TY,Chung KW,Hong SJ,Jeon MJ,Kim TY,Shong YK,Kim WB,Kim WG,Song DE

更新日期：2019-06-01 00:00:00

abstract：:Synchronous occurrence of medullary and papillary carcinoma of the thyroid gland is very rare. We describe two cases of synchronous medullary and papillary carcinoma of the thyroid. In both cases, medullary carcinoma and papillary carcinoma were separate in the thyroid but mixed in some of the lymph node metastases. A...

journal_title：Endocrine pathology

authors： Seki T,Kameyama K,Hayashi H,Nagahama M,Masudo K,Fukunari N,Tanaka K,Sugino K,Ito K,Takami H

更新日期：2004-04-01 00:00:00

abstract：:Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...

journal_title：Endocrine pathology

authors： Harach HR,Bergholm U

更新日期：1993-03-01 00:00:00

abstract：:Breast carcinomas often metastasize into various organs, most commonly into the lung and rather infrequently into the pineal gland. There were only 20 cases of the latter recorded until 1950. Currently, the total number of reported cases, including this report, is 74. At Sunnybrook Health Science Centre, between 1984 ...

journal_title：Endocrine pathology

authors： Kerenyi NA,Pandula E,Feuer GM

更新日期：1994-03-01 00:00:00

abstract：:Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cell...

journal_title：Endocrine pathology

authors： Sumi T,Stefeneanu L,Kovacs K

更新日期：1993-09-01 00:00:00

abstract：:Nonradioisotopic electron microscopic (EM) in situ hybridization (ISH) (EM-SH) with biotinylated oligonucleotide probes is utilized for the ultrastructural visualization of pituitary hormone mRNA in rat pituitary cells. EMISH is an important tool for clarifying the intracellular localization of mRNA and the exact site...

journal_title：Endocrine pathology

authors： Matsuno A,Itoh J,Osamura RY,Watanabe K,Nagashima T

更新日期：1999-10-01 00:00:00

abstract：:Crohn's disease is one of the causes of secondary amyloidosis, which can lead to amyloid infiltration of the thyroid gland. It is essential to follow strict controls to prevent the appearance of a large amyloid goiter. Two patients with amyloid goiter secondary to Crohn's disease, with a large adipose tissue component...

journal_title：Endocrine pathology

authors： Febrero B,Ríos A,Rodríguez JM,Ferri B,Polo L,Parrilla P

更新日期：2012-12-01 00:00:00

abstract：:Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...

journal_title：Endocrine pathology

authors： Powers JF,Tsokas P,Tischler AS

更新日期：1998-01-01 00:00:00

abstract：:Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...

journal_title：Endocrine pathology

authors： Kasem K,Lam AK

更新日期：2014-12-01 00:00:00

abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...

journal_title：Endocrine pathology

authors： Abbona G,Papotti M,Gasparri G,Bussolati G

更新日期：1996-04-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...

journal_title：Endocrine pathology

authors： Yokoyama S,Stefaneanu L,Kovacs K

更新日期：1997-10-01 00:00:00

abstract：:Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...

journal_title：Endocrine pathology

authors： Rowe ME,Ozbek U,Machado RA,Yue LE,Hernandez-Prera JC,Valentino A,Qazi M,Brandwein-Weber M,Liu X,Wenig BM,Urken ML

更新日期：2018-03-01 00:00:00

abstract：:High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...

journal_title：Endocrine pathology

authors： Gupta S,Sahu D,Bomalaski JS,Frank I,Boorjian SA,Thapa P,Cheville JC,Hansel DE

更新日期：2018-09-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...

journal_title：Endocrine pathology

authors： Roy M,Buehler DG,Zhang R,Schwalbe ML,Baus RM,Salamat MS,Lloyd RV,Rosenbaum JN

更新日期：2019-03-01 00:00:00

abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...

journal_title：Endocrine pathology

authors： Crescenzi A,Fulciniti F,Bongiovanni M,Giovanella L,Trimboli P

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...

journal_title：Endocrine pathology

authors： Thompson LD,Wieneke JA,Heffess CS

更新日期：2005-01-01 00:00:00