Abstract：
:Objective. Information on angiogenesis in parathyroid pathology is scanty and in particular no data are available in parathyroid carcinomas. The aim of this study was to analyze angiogenesis as microvascular density (MVD) in parathyroid neoplastic progression from normal gland to adenoma and carcinoma. Methods. Sections from formalin-fixed, paraffin-embedded specimens of 33 normal parathyroids, 43 sporadic parathyroid adenomas, and 6 parathyroid carcinomas were cut for immunohistochemistry using anti-endothelial marker CD34. MVD was evaluated in each specimen as number microvessels per mm2. MVD data were compared with some anatomoclinical parameters as tumor size, serum calcium, and parathyroid hormone (PTH) level. Results. All normal parathyroid glands, all carcinomas, and 8 adenomas out of 43 (18%) showed MVD less than 100 microvessels/mm2 (median 70.8; 95%CI 66.9-88.5); in the majority of parathyroid adenomas (n = 35; 82%) the number of microvessels/mm2 was higher than 100 (median 188.3; 95%CI 174.9-210.1). In adenomas both preoperative serum intact PTH concentration and the diameters were significantly and inversely related to the microvessel density (r = 0.320, p < 0.05 and r = 0.334, p < 0.05, respectively). Conclusions. This study shows that in parathyroid adenomas MVD is heterogeneous and negatively related to the endocrine activity (secretory status and tumor size). Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Viacava P,Bocci G,Fanelli G,Cetani F,Marcocci C,Bevilacqua G,Naccarato AGdoi
10.1385/ep:17:2:175subject
Has Abstractpub_date
2006-07-01 00:00:00pages
175-81issue
2eissn
1046-3976issn
1559-0097pii
EP:17:2:175journal_volume
17pub_type
杂志文章abstract：:Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human br...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:11:1:57
更新日期：2000-04-01 00:00:00
abstract：:Using conventional histological technique, we investigated 44 adenomas (31 men, 13 women) incidentally found in 36 pituitaries (25 men, 11 women) obtained from 1,117 unselected autopsies. The overall incidence of adenomas was 3.2% (men, 3.8%; women, 2.4%) without any significant sex predominance. Size, age distributio...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02921376
更新日期：1994-06-01 00:00:00
abstract：:Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:17:1:53
更新日期：2006-04-01 00:00:00
abstract：:The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-015-9401-8
更新日期：2015-12-01 00:00:00
abstract：:Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739877
更新日期：1995-07-01 00:00:00
abstract：:We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis. The patient was diagnosed with breast cancer and received chemotherapy 3 years before parathyroidectomy. The question can be raised whether chemotherapeutic agents may damage pa...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-007-0001-0
更新日期：2007-04-01 00:00:00
abstract：:Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915325
更新日期：1991-03-01 00:00:00
abstract：:The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9577-4
更新日期：2019-06-01 00:00:00
abstract：:A cell fine of human medullary carcinoma of the thyroid, abundantly producing calcitonin (Ct) and related hormones, has proved remarkably useful as an endocrine tumor model for the study of the secretion mechanism. This cell line (TT cell) was used in studies to elucidate the dynamics of the release of Ct and chromogr...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915322
更新日期：1991-03-01 00:00:00
abstract：:Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:12:2:147
更新日期：2001-07-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-008-9054-y
更新日期：2009-04-01 00:00:00
abstract：:Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin- and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report the first case of an association between craniopharyngioma ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-009-9065-3
更新日期：2009-04-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:4:329
更新日期：2003-01-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-012-9220-0
更新日期：2012-12-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915391
更新日期：1990-09-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-014-9303-1
更新日期：2014-09-01 00:00:00
abstract：:The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739950
更新日期：1998-04-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:14:1:25
更新日期：2003-04-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02738793
更新日期：1997-10-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915452
更新日期：1991-09-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9571-x
更新日期：2019-06-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:15:1:83
更新日期：2004-04-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02921487
更新日期：1994-12-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9545-4
更新日期：2018-12-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9455-2
更新日期：2016-12-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9518-7
更新日期：2018-03-01 00:00:00
abstract：:Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02914490
更新日期：1993-03-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02921341
更新日期：1992-03-01 00:00:00
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journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-010-9142-7
更新日期：2011-03-01 00:00:00
abstract：:The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9476-5
更新日期：2017-06-01 00:00:00
