Rare pediatric adrenocortical carcinoma with oncocytic change: a cytologic dilemma.

abstract：:Pheochromocytomas and paragangliomas are neuroendocrine neoplasias of neural crest origin. Genetic mutations that are characterized in other human neoplasms are rarely seen in these tumors. About 10% of the patients with pheochromocytomas and paragangliomas present with a family history of von Hippel-Lindau disease (V...

journal_title：Endocrine pathology

authors： Dannenberg H,Komminoth P,Dinjens WN,Speel EJ,de Krijger RR

更新日期：2003-01-01 00:00:00

abstract：:A case of ectopic thymic tissue of the thyroid in a 30-year-old woman with Graves' disease is reported. The thyroidectomy specimen, removed because of failure of medical therapy, showed a continuous track of thymic tissue extending from the center of the gland to the capsule along an interiobular septum. This finding ...

journal_title：Endocrine pathology

authors： Mizukami Y,Nanomura A,Michigishi T,Noguchi N,Nakamura S

更新日期：1993-09-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00

abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...

journal_title：Endocrine pathology

authors： Crescenzi A,Fulciniti F,Bongiovanni M,Giovanella L,Trimboli P

更新日期：2017-03-01 00:00:00

abstract：:The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to p...

journal_title：Endocrine pathology

authors： Girolami I,Pantanowitz L,Mete O,Brunelli M,Marletta S,Colato C,Trimboli P,Crescenzi A,Bongiovanni M,Barbareschi M,Eccher A

更新日期：2020-09-01 00:00:00

abstract：:Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the ...

journal_title：Endocrine pathology

authors： Ho YH,Yap WM,Chuah KL

更新日期：2010-06-01 00:00:00

abstract：:A case of pancreatic acinar cell tumor (ACC) is presented in a 10-year-old boy. The tumor manifested clinically with Cushing's syndrome, high serum adrenocorticotropic hormone (ACTH) and cortisol concentrations. In addition, excessive serum levels of alpha-fetoprotein (AFP) were detected. Surgical resection was not po...

journal_title：Endocrine pathology

authors： Illyés G,Luczay A,Benyó G,Kálmán A,Borka K,Köves K,Rácz K,Tulassay T,Schaff Z

更新日期：2007-07-01 00:00:00

abstract：:We report a very rare case of Cushing's syndrome caused by an ileal adrenocorticotrophin-secreting well-differentiated endocrine carcinoma with liver metastases. A 62-yr-old woman presented with clinical and biological signs suggestive of paraneoplastic Cushing's syndrome Radiological investigations, including magneti...

journal_title：Endocrine pathology

authors： Valo I,Rohmer V,Guyetant S,Martin JF,Venault S,Saint-Andre JP

更新日期：2000-01-01 00:00:00

abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...

journal_title：Endocrine pathology

authors： Carr R,Ustun B,Chhieng D,Schofield K,Theoharis C,Hammers L,Adeniran AJ

更新日期：2013-06-01 00:00:00

abstract：:The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. We report the clinical history and the laboratory, imaging, and histopathological findings of a 47-year-old man affecte...

journal_title：Endocrine pathology

authors： Fibbi B,Pinzani P,Salvianti F,Rossi M,Petrone L,De Feo ML,Panconesi R,Vezzosi V,Bianchi S,Simontacchi G,Mangoni M,Pertici M,Forti G,Pupilli C

更新日期：2014-09-01 00:00:00

abstract：:Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...

journal_title：Endocrine pathology

authors： Díaz Del Arco C,Díaz Pérez JÁ,Ortega Medina L,Sastre Valera J,Fernández Aceñero MJ

更新日期：2016-12-01 00:00:00

abstract：:Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recent...

journal_title：Endocrine pathology

authors： Zhang X,Guo M,Yang J,Zheng Y,Xiao Y,Liu W,Ren F

更新日期：2019-03-01 00:00:00

abstract：:The pituitary contains estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR). In accordance with immunocytochemistry, it is agreed that sex hormone receptors reside into the nucleus. All three receptors are found predominantly in gonadotrophs and lactotrophs, and less frequently in other cell ...

journal_title：Endocrine pathology

authors： Stefaneanu L

更新日期：1997-07-01 00:00:00

abstract：:Efforts to understand the pathobiology of pheochromocytomas and extra-adrenal paragangliomas have been spurred by genetic and gene expression profiling studies showing genotype-phenotype correlations in familial pheochromocytoma/paraganglioma syndromes and in some sporadic tumors. The current challenge is to relate ca...

journal_title：Endocrine pathology

authors： Tischler AS

更新日期：2006-01-01 00:00:00

abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...

journal_title：Endocrine pathology

authors： Hellman P,Bjerneroth G,Juhlin C,Ridefelt P,Rastad J,Åkerström G,Jüppner H

更新日期：1990-09-01 00:00:00

abstract：:Recent advances in molecular pathology have shed light not only on the cellular composition and derivation of various tumors, but also on their growth potential, likelihood of recurrence, and prognosis. The development of reliable and prognostically informative methods of assessing tumor behavior is particularly impor...

journal_title：Endocrine pathology

authors： Suhardja A,Kovacs K,Greenberg O,Scheithauer BW,Lloyd RV

更新日期：2005-04-01 00:00:00

abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...

journal_title：Endocrine pathology

authors： Rego KG,Billerbeck AE,Targovnik HM,Santos CL,Alkmin MG,Barbosa S,Camargo R,Medeiros-Neto G

更新日期：1997-04-01 00:00:00

abstract：:Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...

journal_title：Endocrine pathology

authors： Ghigna MR,Dorfmuller P,Crutu A,Fadel E,de Montpréville VT

更新日期：2016-12-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...

journal_title：Endocrine pathology

authors： Roy M,Buehler DG,Zhang R,Schwalbe ML,Baus RM,Salamat MS,Lloyd RV,Rosenbaum JN

更新日期：2019-03-01 00:00:00

abstract：:A case of localized adiposity of the thyroid in a 35-year-old woman with a long history of steroid therapy for nephrotic syndrome is reported. A well-demarcated yellowish mass measuring 2 cm in diameter was found in the upper portion of the right lobe of the thyroid. Microscopically, this lesion was composed of mature...

journal_title：Endocrine pathology

authors： Morizumi H,Sano T,Tsuyuguchi M,Yoshinarl T,Morimoto S

更新日期：1991-12-01 00:00:00

abstract：:High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...

journal_title：Endocrine pathology

authors： Gupta S,Sahu D,Bomalaski JS,Frank I,Boorjian SA,Thapa P,Cheville JC,Hansel DE

更新日期：2018-09-01 00:00:00

abstract：:In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...

journal_title：Endocrine pathology

authors： Lee SH,Baek JS,Lee JY,Lim JA,Cho SY,Lee TH,Ku YH,Kim HI,Kim MJ

更新日期：2013-12-01 00:00:00

abstract：:Transcription factors play specific roles in the development and differentiation of normal pituitary tissues and pituitary adenoma. The transcription factor, muscle segment homeobox 1 (MSX1), which belongs to the homeobox gene family, binds the promoter region of the glycoprotein hormone alpha-subunit (SU) in TSH-prod...

journal_title：Endocrine pathology

authors： Mizokami Y,Egashira N,Takekoshi S,Itoh J,Itoh Y,Osamura RY,Matsumae M

更新日期：2008-04-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...

journal_title：Endocrine pathology

authors： Yokoyama S,Stefaneanu L,Kovacs K

更新日期：1997-10-01 00:00:00

abstract：:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 e...

journal_title：Endocrine pathology

authors： Righi A,Zhang S,Jin L,Scheithauer BW,Kovacs K,Kovacs G,Goth MI,Korbonits M,Lloyd RV

更新日期：2010-03-01 00:00:00

abstract：:CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. The scope of the present study was to validate their role in PC patients and investigate potential application in clinical practice. Data was collected from patients presenting to...

journal_title：Endocrine pathology

authors： Papaxoinis G,Nonaka D,O'Brien C,Sanderson B,Krysiak P,Mansoor W

更新日期：2017-03-01 00:00:00

abstract：:Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...

journal_title：Endocrine pathology

authors： Shan L,Iwasaki A,Utsunomiya H,Kawano I,Matsuura N,Kobayashi A,Kuma K,Kakudo K

更新日期：1995-07-01 00:00:00

abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...

journal_title：Endocrine pathology

authors： Gucer H,Bagci P,Bedir R,Sehitoglu I,Mete O

更新日期：2016-09-01 00:00:00

abstract：:The history of pituitary pathology is a long one that dates back to biblical times, but the last 25 years have represented an era of "coming of age." The role of the pituitary in health and disease was the subject of many studies over the last century. With the development of electron microscopy, immunoassays, and imm...

journal_title：Endocrine pathology

authors： Asa SL,Mete O

更新日期：2014-03-01 00:00:00

abstract：:The adrenal gland is the body's primary source for epinephrine production and release, and the chromaffin cells that comprise the adrenal medulla possess all of the catecholamine biosynthetic machinery, including phenylethanolamine N-methyltransferase (PNMT), the enzyme synthesizing epinephrine from norepinephrine. In...

journal_title：Endocrine pathology

authors： Wong DL

更新日期：2003-04-01 00:00:00