Programmed Death-Ligand 1 (PD-L1) Is a Potential Biomarker of Disease-Free Survival in Papillary Thyroid Carcinoma: a Systematic Review and Meta-Analysis of PD-L1 Immunoexpression in Follicular Epithelial Derived Thyroid Carcinoma.

abstract：:Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...

journal_title：Endocrine pathology

authors： Savin S,Cvejic D,Isic T,Petrovic I,Paunovic I,Tatic S,Havelka M

更新日期：2006-04-01 00:00:00

abstract：:Papillary carcinomas (PCs) of thyroid are among the most common but least aggressive human malignancies. The factors explaining the indolence of these tumors are unknown but host-tumor immune interactions may play a role. This study was designed to determine if there is morphologic evidence of these. Frozen tissues co...

journal_title：Endocrine pathology

authors： Raphael SL,Asa SL

更新日期：1995-10-01 00:00:00

abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...

journal_title：Endocrine pathology

authors： Crescenzi A,Fulciniti F,Bongiovanni M,Giovanella L,Trimboli P

更新日期：2017-03-01 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...

journal_title：Endocrine pathology

authors： Akbulut D,Kuz ED,Kursun N,Dizbay Sak S

更新日期：2021-01-04 00:00:00

abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...

journal_title：Endocrine pathology

authors： Carr R,Ustun B,Chhieng D,Schofield K,Theoharis C,Hammers L,Adeniran AJ

更新日期：2013-06-01 00:00:00

abstract：:Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...

journal_title：Endocrine pathology

authors： Díaz Del Arco C,Díaz Pérez JÁ,Ortega Medina L,Sastre Valera J,Fernández Aceñero MJ

更新日期：2016-12-01 00:00:00

abstract：:We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be mor...

journal_title：Endocrine pathology

authors： Farhat NA,Powers JF,Shepard-Barry A,Dahia P,Pacak K,Tischler AS

更新日期：2019-06-01 00:00:00

abstract：:The incidence and histology of cysts in the adenohypophysis of adult male Wistar rats are reported. Of sixty pituitaries studied 13 of them (21.6%) presented a single cyst located in the pars distalis. The cysts varied in shape and size and were usually multilocular. Two of them were connected with the subdural space ...

journal_title：Endocrine pathology

authors： Quintanar-Stephano A,Muñoz Fernández L,Quintanar JL,Kovacs K

更新日期：2001-04-01 00:00:00

abstract：:A cell fine of human medullary carcinoma of the thyroid, abundantly producing calcitonin (Ct) and related hormones, has proved remarkably useful as an endocrine tumor model for the study of the secretion mechanism. This cell line (TT cell) was used in studies to elucidate the dynamics of the release of Ct and chromogr...

journal_title：Endocrine pathology

authors： Kameya T,Kadoya K,Iguchi H,Abe Y,Shimaoka K

更新日期：1991-03-01 00:00:00

abstract：:The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...

journal_title：Endocrine pathology

authors： Franscella S,Favrod-Coune CA,Pizzolato G,Asa SL,Gaillard R,Berney J,Philippe J

更新日期：1991-06-01 00:00:00

abstract：:A 59-yr old female presented with Cushing's syndrome due to ectopic ACTH production. At the time of initial diagnosis an obvious source for the Cushing's syndrome was not found and the patient was treated with bilateral adrenalectomy. Three years later she presented with hyperpigmentation and evidence of ACTH overprod...

journal_title：Endocrine pathology

authors： Chetty R,Serra S

更新日期：2005-07-01 00:00:00

abstract：:Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...

journal_title：Endocrine pathology

authors： Duan K,Asa SL,Winer D,Gelareh Z,Gentili F,Mete O

更新日期：2017-03-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumor...

journal_title：Endocrine pathology

authors： Roy M,Buehler DG,Zhang R,Schwalbe ML,Baus RM,Salamat MS,Lloyd RV,Rosenbaum JN

更新日期：2019-03-01 00:00:00

abstract：:Using conventional histological technique, we investigated 44 adenomas (31 men, 13 women) incidentally found in 36 pituitaries (25 men, 11 women) obtained from 1,117 unselected autopsies. The overall incidence of adenomas was 3.2% (men, 3.8%; women, 2.4%) without any significant sex predominance. Size, age distributio...

journal_title：Endocrine pathology

authors： Uei Y,Kanzaki M,Yabana T

更新日期：1994-06-01 00:00:00

abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...

journal_title：Endocrine pathology

authors： Nosé V,Volante M,Papotti M

更新日期：2008-04-01 00:00:00

abstract：:The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...

journal_title：Endocrine pathology

authors： Hunt JL,Baloch ZW,Barnes L,Swalsky PA,Trusky CL,Sesatomi E,Finkelstein S,LiVolsi VA

更新日期：2002-01-01 00:00:00

abstract：:C cell hyperplasia is considered a precursor lesion for hereditary forms of medullary thyroid carcinoma. It has therefore been suggested as a morphological marker to distinguish hereditary from sporadic medullary thyroid carcinoma and to triage genetic testing in resource poor settings. However, numerous definitions f...

journal_title：Endocrine pathology

authors： Fuchs TL,Bell SE,Chou A,Gill AJ

更新日期：2019-06-01 00:00:00

abstract：:There is evidence that programmed death-ligand 1 (PD-L1) is expressed by thyroid follicular epithelium in thyroiditis, but the role of PD-L1 in papillary thyroid carcinoma (PTC) is poorly understood. We aimed to determine whether (1) the presence of background chronic lymphocytic thyroiditis (CLT) or Hashimoto thyroid...

journal_title：Endocrine pathology

authors： Lubin D,Baraban E,Lisby A,Jalali-Farahani S,Zhang P,Livolsi V

更新日期：2018-12-01 00:00:00

abstract：:Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...

journal_title：Endocrine pathology

authors： Giordano TJ

更新日期：2003-07-01 00:00:00

abstract：:Objective. Information on angiogenesis in parathyroid pathology is scanty and in particular no data are available in parathyroid carcinomas. The aim of this study was to analyze angiogenesis as microvascular density (MVD) in parathyroid neoplastic progression from normal gland to adenoma and carcinoma. Methods. Sectio...

journal_title：Endocrine pathology

authors： Viacava P,Bocci G,Fanelli G,Cetani F,Marcocci C,Bevilacqua G,Naccarato AG

更新日期：2006-07-01 00:00:00

abstract：:Pediatric adrenocortical carcinoma is extremely rare with a prevalence of 0.3 per million. Adrenocortical neoplasms in children usually present with one of the endocrine abnormalities. Adrenocortical neoplasms cannot be easily diagnosed on cytopathology; hence, the cytomorphological features posing diagnostic dilemmas...

journal_title：Endocrine pathology

authors： Agarwal S,Agarwal K

更新日期：2011-03-01 00:00:00

abstract：:Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...

journal_title：Endocrine pathology

authors： Salgado LR,Mendonca BB,Goldman J,Semer M,Knoepfelmacher M,Tsanaclis AM,Wajchenberg BL,Liberman B

更新日期：1995-04-01 00:00:00

abstract：:Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the ...

journal_title：Endocrine pathology

authors： Ho YH,Yap WM,Chuah KL

更新日期：2010-06-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00

abstract：:Alterations of the von Hippel-Lindau (VHL) gene, which is supposed to act as a tumor suppressor gene, can cause hereditary tumors associated with the VHL syndrome and are found in different sporadic cancers as well. While VHL protein is distinctly detectable in thyroid follicles, so far its expression in nonneoplastic...

journal_title：Endocrine pathology

authors： Hinze R,Boltze C,Meye A,Holzhausen HJ,Dralle H,Rath FW

更新日期：2000-07-01 00:00:00

abstract：:Hurthle cell carcinoma of the thyroid is generally considered to be a subtype of follicular carcinoma. We report a case of a small solitary usual-type papillary carcinoma of the thyroid, with metastatic tumor in cervical lymph nodes. The lymph node tumor consisted of both tall-cell papillary carcinoma and Hurthle cell...

journal_title：Endocrine pathology

authors： Zwi LJ,LiVolsi VA

更新日期：2002-10-01 00:00:00

abstract：:Understanding the molecular mechanisms involved in thyroid cancer progression may provide targets for more effective treatment of aggressive thyroid cancers. Epithelial mesenchymal transition (EMT) is a major pathologic mechanism in tumor progression and is linked to the acquisition of stem-like properties of cancer c...

journal_title：Endocrine pathology

authors： Montemayor-Garcia C,Hardin H,Guo Z,Larrain C,Buehler D,Asioli S,Chen H,Lloyd RV

更新日期：2013-12-01 00:00:00

abstract：:Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. T...

journal_title：Endocrine pathology

authors： Treilleux I,Freyer G,Tabone E,Chassagne-Clement C,Bremond A,Bailly C

更新日期：1997-10-01 00:00:00

abstract：:The cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity that is associated with familial adenomatous polyposis (FAP). We report a case of a young lady with an incidentally discovered right-sided neck nodule on ultrasonography with a diagnosis of CMV-PTC confirmed on thyroid...

journal_title：Endocrine pathology

authors： Yeoh EC,Lim LC,Ng SB,Tan KY,Rajasoorya C

更新日期：2014-09-01 00:00:00

abstract：:Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...

journal_title：Endocrine pathology

authors： Kasem K,Lam AK

更新日期：2014-12-01 00:00:00