The role of epithelial mesenchymal transition markers in thyroid carcinoma progression.

abstract：:Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. T...

journal_title：Endocrine pathology

authors： Treilleux I,Freyer G,Tabone E,Chassagne-Clement C,Bremond A,Bailly C

更新日期：1997-10-01 00:00:00

abstract：:Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recent...

journal_title：Endocrine pathology

authors： Zhang X,Guo M,Yang J,Zheng Y,Xiao Y,Liu W,Ren F

更新日期：2019-03-01 00:00:00

abstract：:We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating...

journal_title：Endocrine pathology

authors： Rotondo F,Qaddoura A,Syro LV,Karamchandani J,Munoz DG,Arroyave MJ,Ospina WP,Cusimano MD,Kovacs K

更新日期：2017-12-01 00:00:00

abstract：:Breast carcinomas often metastasize into various organs, most commonly into the lung and rather infrequently into the pineal gland. There were only 20 cases of the latter recorded until 1950. Currently, the total number of reported cases, including this report, is 74. At Sunnybrook Health Science Centre, between 1984 ...

journal_title：Endocrine pathology

authors： Kerenyi NA,Pandula E,Feuer GM

更新日期：1994-03-01 00:00:00

abstract：:Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...

journal_title：Endocrine pathology

authors： Savin S,Cvejic D,Isic T,Petrovic I,Paunovic I,Tatic S,Havelka M

更新日期：2006-04-01 00:00:00

abstract：:Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...

journal_title：Endocrine pathology

authors： Duan K,Asa SL,Winer D,Gelareh Z,Gentili F,Mete O

更新日期：2017-03-01 00:00:00

abstract：:Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...

journal_title：Endocrine pathology

authors： Satoh F,Umemura S,Yasuda M,Osamura RY

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Previous studies have established that calcitonin (CT) and the calcitonin generelated peptide (CGRP) are synthesized and stored in subsets of hyperplastic parathyroid cells that also contain chromogranin B (Schmid, KW, et al. Lab Invest 73:90, 1995). The purpose of the current study was to determine whether ...

journal_title：Endocrine pathology

authors： Khan A,Tischler AS,Patwardhan NA,DeLellis RA

更新日期：2003-10-01 00:00:00

abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...

journal_title：Endocrine pathology

authors： Hellman P,Bjerneroth G,Juhlin C,Ridefelt P,Rastad J,Åkerström G,Jüppner H

更新日期：1990-09-01 00:00:00

abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...

journal_title：Endocrine pathology

authors： Abbona G,Papotti M,Gasparri G,Bussolati G

更新日期：1996-04-01 00:00:00

abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...

journal_title：Endocrine pathology

authors： Gucer H,Bagci P,Bedir R,Sehitoglu I,Mete O

更新日期：2016-09-01 00:00:00

abstract：:Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is ...

journal_title：Endocrine pathology

authors： Kimura N,Togo A,Sugimoto T,Nata K,Okamoto H,Nagatsu I,Nagura H

更新日期：1996-07-01 00:00:00

abstract：:Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...

journal_title：Endocrine pathology

authors： Pilichowska M,Kimura N,Schindler M,Kobari M

更新日期：2001-07-01 00:00:00

abstract：:The pituitary contains estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR). In accordance with immunocytochemistry, it is agreed that sex hormone receptors reside into the nucleus. All three receptors are found predominantly in gonadotrophs and lactotrophs, and less frequently in other cell ...

journal_title：Endocrine pathology

authors： Stefaneanu L

更新日期：1997-07-01 00:00:00

abstract：:The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...

journal_title：Endocrine pathology

authors： Wong KS,Strickland KC,Angell TE,Nehs MA,Alexander EK,Cibas ES,Krane JF,Howitt BE,Barletta JA

更新日期：2017-06-01 00:00:00

abstract：:Pediatric adrenocortical carcinoma is extremely rare with a prevalence of 0.3 per million. Adrenocortical neoplasms in children usually present with one of the endocrine abnormalities. Adrenocortical neoplasms cannot be easily diagnosed on cytopathology; hence, the cytomorphological features posing diagnostic dilemmas...

journal_title：Endocrine pathology

authors： Agarwal S,Agarwal K

更新日期：2011-03-01 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...

journal_title：Endocrine pathology

authors： Akbulut D,Kuz ED,Kursun N,Dizbay Sak S

更新日期：2021-01-04 00:00:00

abstract：:Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...

journal_title：Endocrine pathology

authors： Shan L,Iwasaki A,Utsunomiya H,Kawano I,Matsuura N,Kobayashi A,Kuma K,Kakudo K

更新日期：1995-07-01 00:00:00

abstract：:In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...

journal_title：Endocrine pathology

authors： Lee SH,Baek JS,Lee JY,Lim JA,Cho SY,Lee TH,Ku YH,Kim HI,Kim MJ

更新日期：2013-12-01 00:00:00

abstract：:A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...

journal_title：Endocrine pathology

authors： Chetty R,Kennedy M,Ezzat S,Asa SL

更新日期：2004-07-01 00:00:00

abstract：:Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In add...

journal_title：Endocrine pathology

authors： La Rosa S,Bernasconi B,Micello D,Finzi G,Capella C

更新日期：2009-04-01 00:00:00

abstract：:Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...

journal_title：Endocrine pathology

authors： Zheng Z,Zhou X,Cai Y,Chen E,Zhang X,Wang O,Wang Q,Liu H

更新日期：2018-12-01 00:00:00

abstract：:Transcription factors play specific roles in the development and differentiation of normal pituitary tissues and pituitary adenoma. The transcription factor, muscle segment homeobox 1 (MSX1), which belongs to the homeobox gene family, binds the promoter region of the glycoprotein hormone alpha-subunit (SU) in TSH-prod...

journal_title：Endocrine pathology

authors： Mizokami Y,Egashira N,Takekoshi S,Itoh J,Itoh Y,Osamura RY,Matsumae M

更新日期：2008-04-01 00:00:00

abstract：:Various ultrasonographic characteristics of thyroid nodules have been associated with a higher likelihood of malignancy, and certain clinical features may also increase the likelihood of malignancy in patients. This study is designed to determine the ultrasonographic and clinical predictors of malignancy in the atypia...

journal_title：Endocrine pathology

authors： Carr R,Ustun B,Chhieng D,Schofield K,Theoharis C,Hammers L,Adeniran AJ

更新日期：2013-06-01 00:00:00

abstract：:We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be mor...

journal_title：Endocrine pathology

authors： Farhat NA,Powers JF,Shepard-Barry A,Dahia P,Pacak K,Tischler AS

更新日期：2019-06-01 00:00:00

abstract：:The cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity that is associated with familial adenomatous polyposis (FAP). We report a case of a young lady with an incidentally discovered right-sided neck nodule on ultrasonography with a diagnosis of CMV-PTC confirmed on thyroid...

journal_title：Endocrine pathology

authors： Yeoh EC,Lim LC,Ng SB,Tan KY,Rajasoorya C

更新日期：2014-09-01 00:00:00

abstract：:The history of pituitary pathology is a long one that dates back to biblical times, but the last 25 years have represented an era of "coming of age." The role of the pituitary in health and disease was the subject of many studies over the last century. With the development of electron microscopy, immunoassays, and imm...

journal_title：Endocrine pathology

authors： Asa SL,Mete O

更新日期：2014-03-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...

journal_title：Endocrine pathology

authors： Yokoyama S,Stefaneanu L,Kovacs K

更新日期：1997-10-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00

abstract：:Non-coding (nc)RNAs are divided into small ncRNAs and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are small ncRNAS which are around 22 nucleotides in length that mediate post-transcriptional gene silencing. LncRNAs are greater than 200 bp in length. Each ncRNA can have multiple targets and can be regulated by multiple g...

journal_title：Endocrine pathology

authors： Zhang R,Hardin H,Chen J,Guo Z,Lloyd RV

更新日期：2016-03-01 00:00:00