Abstract:
:Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic channels, but the bulk of metastatic tumor was confined within the thyroid carcinoma. Immunohistochemical stains as well as molecular studies confirmed the origin of both donor tumors, as well as the diagnosis of follicular variant of papillary carcinoma in the recipient tumors. Distinguishing between two such tumor populations may be difficult when the donor tumor cells morphologically resemble primary neoplasms of the recipient organ. A history of previous malignancy and ancillary studies can be helpful in making this distinction and rendering the correct diagnosis. A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Yu J,Nikiforova MN,Hodak SP,Yim JH,Cai G,Walls A,Nikiforov YE,Seethala RRdoi
10.1007/s12022-009-9087-xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
235-42issue
4eissn
1046-3976issn
1559-0097journal_volume
20pub_type
杂志文章abstract::Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significant...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9518-7
更新日期:2018-03-01 00:00:00
abstract::The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9014-6
更新日期:2008-04-01 00:00:00
abstract::Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. T...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738793
更新日期:1997-10-01 00:00:00
abstract::Nonradioisotopic electron microscopic (EM) in situ hybridization (ISH) (EM-SH) with biotinylated oligonucleotide probes is utilized for the ultrastructural visualization of pituitary hormone mRNA in rat pituitary cells. EMISH is an important tool for clarifying the intracellular localization of mRNA and the exact site...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738881
更新日期:1999-10-01 00:00:00
abstract::Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid ca...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-010-9129-4
更新日期:2010-12-01 00:00:00
abstract::Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:3:291
更新日期:2001-10-01 00:00:00
abstract::Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:2:107
更新日期:2003-07-01 00:00:00
abstract::The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagn...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-017-9476-5
更新日期:2017-06-01 00:00:00
abstract::Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-018-9549-0
更新日期:2018-12-01 00:00:00
abstract::The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739915
更新日期:1996-04-01 00:00:00
abstract::Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739877
更新日期:1995-07-01 00:00:00
abstract::The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921341
更新日期:1992-03-01 00:00:00
abstract::Somatostatin and its analogs have been included in experimental treatment protocols for advanced pancreatic adenocarcinoma based on their known antisecretory and antiproliferative properties. Somatostatin receptor type 2 (sstr2A) mediates antiproliferative actions of somatostatin and has the strongest affinity to the ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:12:2:147
更新日期:2001-07-01 00:00:00
abstract::The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less t...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-017-9483-6
更新日期:2017-06-01 00:00:00
abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09650-1
更新日期:2021-01-04 00:00:00
abstract::Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth fact...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739931
更新日期:1997-01-01 00:00:00
abstract::In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739828
更新日期:1999-06-01 00:00:00
abstract::Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection i...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9571-x
更新日期:2019-06-01 00:00:00
abstract::Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9422-y
更新日期:2016-12-01 00:00:00
abstract::The adrenal gland is the body's primary source for epinephrine production and release, and the chromaffin cells that comprise the adrenal medulla possess all of the catecholamine biosynthetic machinery, including phenylethanolamine N-methyltransferase (PNMT), the enzyme synthesizing epinephrine from norepinephrine. In...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:1:25
更新日期:2003-04-01 00:00:00
abstract::Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed al...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9455-2
更新日期:2016-12-01 00:00:00
abstract::The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739950
更新日期:1998-04-01 00:00:00
abstract::Approximately 90% of neoplasms found in the sellar region are adenoma of the pituitary gland. The use of frozen sections for the diagnosis of pituitary adenomas has an accuracy of 90% and is useful in evaluating complete tumor removal. However, it is sometimes difficult to diagnose pituitary adenomas using frozen sect...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9370-y
更新日期:2015-05-01 00:00:00
abstract::A case of localized adiposity of the thyroid in a 35-year-old woman with a long history of steroid therapy for nephrotic syndrome is reported. A well-demarcated yellowish mass measuring 2 cm in diameter was found in the upper portion of the right lobe of the thyroid. Microscopically, this lesion was composed of mature...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915212
更新日期:1991-12-01 00:00:00
abstract::We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be mor...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-019-9575-6
更新日期:2019-06-01 00:00:00
abstract::Pleomorphic leiomyosarcoma (PLMS) of the adrenal gland is a rare tumor in an unusual location. A primary PLMS of the left adrenal gland is reported in a 59-yr-old Mexican woman who presented progressive flank pain and weight loss. The tumor measured 16 cm in diameter, showed markedly pleomorphic and osteoclast-like gi...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:1:075
更新日期:2005-04-01 00:00:00
abstract::Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915391
更新日期:1990-09-01 00:00:00
abstract::Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In add...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-008-9054-y
更新日期:2009-04-01 00:00:00
abstract::A 41-yr-old patient with a history of von Hippel-Lindau (VHL) disease with previously removed bilateral pheochromocytomas and renal cell carcinoma presented with progressive obstructive jaundice due to multiple lesions in the pancreas. The pancreatectomy specimen showed a range of endocrine lesions including islet hyp...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:15:2:141
更新日期:2004-07-01 00:00:00
abstract::Breast carcinomas often metastasize into various organs, most commonly into the lung and rather infrequently into the pineal gland. There were only 20 cases of the latter recorded until 1950. Currently, the total number of reported cases, including this report, is 74. At Sunnybrook Health Science Centre, between 1984 ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921371
更新日期:1994-03-01 00:00:00