Granular cell tumour of the thyroid gland: a case report and review of the literature.

abstract：:The recent increase in the detection of papillary thyroid carcinoma (PTC) has been influenced by the finding of incidental tumours. To this group, carcinomas measuring less than 1 cm (the so-called microcarcinomas) as well as those above 1 cm belong. Analyzing a case series from our own experience, this paper focuses ...

journal_title：Endocrine pathology

authors： Pagni F,Jaconi M,Delitala A,Garancini M,Maternini M,Bono F,Giani A,Smith A,San Gerardo Hospital collaborators group.

更新日期：2014-09-01 00:00:00

abstract：:Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid ca...

journal_title：Endocrine pathology

authors： Cassol CA,Guo M,Ezzat S,Asa SL

更新日期：2010-12-01 00:00:00

abstract：:The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. We report the clinical history and the laboratory, imaging, and histopathological findings of a 47-year-old man affecte...

journal_title：Endocrine pathology

authors： Fibbi B,Pinzani P,Salvianti F,Rossi M,Petrone L,De Feo ML,Panconesi R,Vezzosi V,Bianchi S,Simontacchi G,Mangoni M,Pertici M,Forti G,Pupilli C

更新日期：2014-09-01 00:00:00

abstract：:Recent advances in molecular pathology have shed light not only on the cellular composition and derivation of various tumors, but also on their growth potential, likelihood of recurrence, and prognosis. The development of reliable and prognostically informative methods of assessing tumor behavior is particularly impor...

journal_title：Endocrine pathology

authors： Suhardja A,Kovacs K,Greenberg O,Scheithauer BW,Lloyd RV

更新日期：2005-04-01 00:00:00

abstract：:Aldosterone-producing adenoma (APA) consisting of pure zona glomerulosa (ZG)-type cells is extremely rare, and primary aldosteronism complicated by pregnancy is also rare. We report a case of APA discovered in a 32-year-old pregnant woman who visited our hospital for hypertension and hypokalemia at 26 weeks gestation....

journal_title：Endocrine pathology

authors： Shigematsu K,Nishida N,Sakai H,Igawa T,Suzuki S,Kawai K,Takahara O

更新日期：2009-04-01 00:00:00

abstract：:To assess the proliferative activity of pituitary adenomas, 36 surgically removed adenomas were studied by light microscopical parameters; mitotic count; expression of PCNA, Ki-67, cathepsin D, and EGF; and image cytometry. Three adenomas (9%) showed high, 11 (34%) medium, 17 (53%) moderate, and 1 (3%) low structural ...

journal_title：Endocrine pathology

authors： Krämer A,Saeger W,Tallen G,Lüdecke DK

更新日期：1994-12-01 00:00:00

abstract：:We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis. The patient was diagnosed with breast cancer and received chemotherapy 3 years before parathyroidectomy. The question can be raised whether chemotherapeutic agents may damage pa...

journal_title：Endocrine pathology

authors： Kovacs K,Bell CD,Juco J,Rotondo F,Anderson J

更新日期：2007-04-01 00:00:00

abstract：:We report clinicopathological features of a large series of synchronous multiple pituitary neuroendocrine tumors (PitNETs) of different cell lineages. Retrospective review of pathology records from 2001 to 2016 identified 13 synchronous multiple PitNETs from 1055 PitNETs classified using pituitary cell-lineage transcr...

journal_title：Endocrine pathology

authors： Mete O,Alshaikh OM,Cintosun A,Ezzat S,Asa SL

更新日期：2018-12-01 00:00:00

abstract：:Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. Th...

journal_title：Endocrine pathology

authors： Slosar M,Vohra P,Prasad M,Fischer A,Quinlan R,Khan A

更新日期：2009-10-01 00:00:00

abstract：:Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recent...

journal_title：Endocrine pathology

authors： Zhang X,Guo M,Yang J,Zheng Y,Xiao Y,Liu W,Ren F

更新日期：2019-03-01 00:00:00

abstract：:Thirteen cases of fatal sporadic medullary carcinoma of the thyroid (MCT) that killed the patient within 1 year after diagnosis were compared with 12 nonfatal MCTs with excellent prognosis. Males predominated in fatal cases whereas the reverse was true in MCTs with good prognosis. The two groups of tumors showed gener...

journal_title：Endocrine pathology

authors： Harach HR,Bergholm U

更新日期：1993-03-01 00:00:00

abstract：:Genomewide profiling of gene expression, made possible by the development of DNA microarray technology and more powerful by the sequencing of the human genome, has led to advances in tumor classification and biomarker discovery for the common types of human neoplasia. Application of this approach to the field of endoc...

journal_title：Endocrine pathology

authors： Giordano TJ

更新日期：2003-07-01 00:00:00

abstract：:Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...

journal_title：Endocrine pathology

authors： Satoh F,Umemura S,Yasuda M,Osamura RY

更新日期：2001-10-01 00:00:00

abstract：:The presence, distribution, and morphological appearance of S-100 protein-immunoreactive cells in the human hypophysis were studied by immunocytochemistry. One hundred and twelve nonadenomatous pituitaries from fetuses to adults and pituitaries affected by several lesions including metastases, acute infarcts, and lymp...

journal_title：Endocrine pathology

authors： Marin F,Kovacs K,Stefaneanu L,Horvath E,Cheng Z

更新日期：1992-03-01 00:00:00

abstract：:Neoplastic plasma cell involvement of thyroid is an uncommon condition, and it may involve thyroid in multiple myeloma or solitary plasmacytoma. Its clinical and pathological features are not well understood. We present a rare case of synchronous thyroid involvement in plasma cell leukemia presenting as thyroid nodule...

journal_title：Endocrine pathology

authors： Tandon A,Paul TR,Singh R,Narendra AM

更新日期：2015-12-01 00:00:00

abstract：:The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...

journal_title：Endocrine pathology

authors： Lloyd RV,Carney JA,Ferreiro JA,Jin L,Thompson GB,Van Heerden JA,Grant CS,Wollan PC

更新日期：1995-01-01 00:00:00

abstract：:Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...

journal_title：Endocrine pathology

authors： Stilling GA,Bayliss JM,Jin L,Zhang H,Lloyd RV

更新日期：2005-10-01 00:00:00

abstract：:The incidence and histology of cysts in the adenohypophysis of adult male Wistar rats are reported. Of sixty pituitaries studied 13 of them (21.6%) presented a single cyst located in the pars distalis. The cysts varied in shape and size and were usually multilocular. Two of them were connected with the subdural space ...

journal_title：Endocrine pathology

authors： Quintanar-Stephano A,Muñoz Fernández L,Quintanar JL,Kovacs K

更新日期：2001-04-01 00:00:00

abstract：:Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...

journal_title：Endocrine pathology

authors： Salgado LR,Mendonca BB,Goldman J,Semer M,Knoepfelmacher M,Tsanaclis AM,Wajchenberg BL,Liberman B

更新日期：1995-04-01 00:00:00

abstract：:The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases we...

journal_title：Endocrine pathology

authors： Abbona G,Papotti M,Gasparri G,Bussolati G

更新日期：1996-04-01 00:00:00

abstract：:The BRAF(V600E) mutation is specific for thyroid papillary cancer (PTC) and correlates with PTCs invasiveness. This study investigated whether detection of BRAF(V600E) mutation can be performed on routinely stained FNABs. We also examined if establishment of the BRAF(V600E) mutation could help in identification of pat...

journal_title：Endocrine pathology

authors： Patel A,Klubo-Gwiezdzinska J,Hoperia V,Larin A,Jensen K,Bauer A,Vasko V

更新日期：2011-12-01 00:00:00

abstract：:In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...

journal_title：Endocrine pathology

authors： Fonseca E,Castanhas S,Sobrinho-Simoes M

更新日期：1996-01-01 00:00:00

abstract：:Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human br...

journal_title：Endocrine pathology

authors： Pilichowska M,Kimura N,Schindler M,Suzuki A,Yoshida R,Nagura H

更新日期：2000-04-01 00:00:00

abstract：:Alterations of the von Hippel-Lindau (VHL) gene, which is supposed to act as a tumor suppressor gene, can cause hereditary tumors associated with the VHL syndrome and are found in different sporadic cancers as well. While VHL protein is distinctly detectable in thyroid follicles, so far its expression in nonneoplastic...

journal_title：Endocrine pathology

authors： Hinze R,Boltze C,Meye A,Holzhausen HJ,Dralle H,Rath FW

更新日期：2000-07-01 00:00:00

abstract：:There is evidence that programmed death-ligand 1 (PD-L1) is expressed by thyroid follicular epithelium in thyroiditis, but the role of PD-L1 in papillary thyroid carcinoma (PTC) is poorly understood. We aimed to determine whether (1) the presence of background chronic lymphocytic thyroiditis (CLT) or Hashimoto thyroid...

journal_title：Endocrine pathology

authors： Lubin D,Baraban E,Lisby A,Jalali-Farahani S,Zhang P,Livolsi V

更新日期：2018-12-01 00:00:00

abstract：:Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islets cells budding off from pancreatic ducts, has been considered for years as the histological lesion responsible for the syndrome. In our m...

journal_title：Endocrine pathology

authors： Sempoux C,Guiot Y,Jaubert F,Rahier J

更新日期：2004-10-01 00:00:00

abstract：:In the majority of cases, Cushing's disease is the result of a small basophilic corticotroph microadenoma with an average size of less than 5 mm. Transsphenoidal microsurgery can cure patients with Cushing's disease; however, selective removal of the lesion requires precise preoperative localization. In this article, ...

journal_title：Endocrine pathology

authors： Booth GL,Smyth HS,Kovacs K,Horvath E,Asa SL,Ezzat S

更新日期：1999-06-01 00:00:00

abstract：:The pituitary contains estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR). In accordance with immunocytochemistry, it is agreed that sex hormone receptors reside into the nucleus. All three receptors are found predominantly in gonadotrophs and lactotrophs, and less frequently in other cell ...

journal_title：Endocrine pathology

authors： Stefaneanu L

更新日期：1997-07-01 00:00:00

abstract：:Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past me...

journal_title：Endocrine pathology

authors： Ghigna MR,Dorfmuller P,Crutu A,Fadel E,de Montpréville VT

更新日期：2016-12-01 00:00:00

abstract：:Non-coding (nc)RNAs are divided into small ncRNAs and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are small ncRNAS which are around 22 nucleotides in length that mediate post-transcriptional gene silencing. LncRNAs are greater than 200 bp in length. Each ncRNA can have multiple targets and can be regulated by multiple g...

journal_title：Endocrine pathology

authors： Zhang R,Hardin H,Chen J,Guo Z,Lloyd RV

更新日期：2016-03-01 00:00:00