Abstract:
:Insulin-like growth factor mRNA binding protein 3 (IMP3) is an mRNA-binding protein that regulates transcription of insulin-like growth factor II affecting cell proliferation during embryogenesis. It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary. The purpose of our study was to evaluate IMP3 expression in thyroid follicular lesions, to determine whether it has a role in differentiating among these lesions, and to understand their biological relationships. We immunostained 219 thyroid lesions selected from our surgical pathology archives including 14 hyperplastic colloid nodules (CN), 19 Hashimoto's thyroiditis (HT), two Graves disease (GD), ten Hürthle cell adenoma (HCA), 20 follicular adenoma (FA), 37 conventional papillary thyroid carcinoma (PTC), 60 follicular variant of papillary carcinoma (FVPC), 19 Hürthle cell carcinoma (HCC), 32 follicular carcinoma (FC), and six poorly differentiated/anaplastic carcinoma. Immunohistochemistry was performed on formalin-fixed sections using monoclonal antibody to IMP3. Clinicopathological data were also reviewed. In all cases, residual thyroid tissue, CN, HT, GD, HCA, and FA were completely negative for IMP3 staining. Of the 60 FVPC, 23 tumors (38%) were positive for IMP3, with 13 of these (22%) showing very strong staining (3+). Of the 32 FC, 22 tumors (69%) were positive, with seven (22%) showing very strong staining (3+). Furthermore, 33 out of 37 cases (89%) of PTC were negative for IMP3. In all four PTC cases that did stain positive, staining was weak-moderate (1-2+). Similarly, 15 out of 19 cases (79%) of HCC were negative. No significant correlation was found between pathologic tumor characteristics and IMP3 expression in differentiated follicular pattern thyroid carcinoma. With 100% specificity and 69% sensitivity for FC as compared to FA and 100% specificity for FVPC, again compared to FA, IMP3 has the potential to be diagnostically useful in differentiating malignant and benign follicular pattern thyroid lesions. This study also points to a possible common biological relationship between FC and FVPC that requires further investigation.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Slosar M,Vohra P,Prasad M,Fischer A,Quinlan R,Khan Adoi
10.1007/s12022-009-9079-xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
149-57issue
3eissn
1046-3976issn
1559-0097journal_volume
20pub_type
杂志文章abstract::Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:17:1:53
更新日期:2006-04-01 00:00:00
abstract::Pheochromocytomas and paragangliomas are neuroendocrine neoplasias of neural crest origin. Genetic mutations that are characterized in other human neoplasms are rarely seen in these tumors. About 10% of the patients with pheochromocytomas and paragangliomas present with a family history of von Hippel-Lindau disease (V...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:14:4:329
更新日期:2003-01-01 00:00:00
abstract::Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739877
更新日期:1995-07-01 00:00:00
abstract::A 59-yr old female presented with Cushing's syndrome due to ectopic ACTH production. At the time of initial diagnosis an obvious source for the Cushing's syndrome was not found and the patient was treated with bilateral adrenalectomy. Three years later she presented with hyperpigmentation and evidence of ACTH overprod...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:2:145
更新日期:2005-07-01 00:00:00
abstract::Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9466-z
更新日期:2017-03-01 00:00:00
abstract::Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739706
更新日期:1997-04-01 00:00:00
abstract::Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-007-9002-2
更新日期:2008-04-01 00:00:00
abstract::Folliculostellate (FS) cells are present in the anterior pituitary and have important regulatory functions including controlling hormone release from other anterior pituitary cells. FS cells do not usually express neuroendocrine genes such as chromogranin A (CgA). We analyzed transcriptional regulation and gene expres...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:3:173
更新日期:2005-10-01 00:00:00
abstract::Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in t...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09612-7
更新日期:2020-06-01 00:00:00
abstract::The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-008-9014-6
更新日期:2008-04-01 00:00:00
abstract::In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively rev...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-013-9263-x
更新日期:2013-12-01 00:00:00
abstract::Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass disco...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1007/s12022-014-9333-8
更新日期:2014-12-01 00:00:00
abstract::Crohn's disease is one of the causes of secondary amyloidosis, which can lead to amyloid infiltration of the thyroid gland. It is essential to follow strict controls to prevent the appearance of a large amyloid goiter. Two patients with amyloid goiter secondary to Crohn's disease, with a large adipose tissue component...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-012-9220-0
更新日期:2012-12-01 00:00:00
abstract::The morphologic distinction between parathyroid carcinoma and adenoma can be a difficult diagnostic problem. We analyzed nuclear immunoreactivity for the cell cycle-associated antigen Ki-67 with monoclonal antibody (MAb) MIB-1 and for retinoblastoma (RB) protein with two polyclonal antisera in 24 parathyroid carcinoma...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738728
更新日期:1995-01-01 00:00:00
abstract::Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02738783
更新日期:1997-10-01 00:00:00
abstract::Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739972
更新日期:1996-07-01 00:00:00
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journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9464-1
更新日期:2017-12-01 00:00:00
abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called "encapsulated" (conventional) variant of papillary thyroid carcinoma. We aimed to investigate the clinicopathological features of this...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-020-09650-1
更新日期:2021-01-04 00:00:00
abstract::Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-009-9087-x
更新日期:2009-01-01 00:00:00
abstract::To assess the proliferative activity of pituitary adenomas, 36 surgically removed adenomas were studied by light microscopical parameters; mitotic count; expression of PCNA, Ki-67, cathepsin D, and EGF; and image cytometry. Three adenomas (9%) showed high, 11 (34%) medium, 17 (53%) moderate, and 1 (3%) low structural ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02921487
更新日期:1994-12-01 00:00:00
abstract::Approximately 90% of neoplasms found in the sellar region are adenoma of the pituitary gland. The use of frozen sections for the diagnosis of pituitary adenomas has an accuracy of 90% and is useful in evaluating complete tumor removal. However, it is sometimes difficult to diagnose pituitary adenomas using frozen sect...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9370-y
更新日期:2015-05-01 00:00:00
abstract::The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title:Endocrine pathology
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doi:10.1007/s12022-019-9577-4
更新日期:2019-06-01 00:00:00
abstract::Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medul...
journal_title:Endocrine pathology
pub_type: 杂志文章,评审
doi:10.1385/ep:12:4:365
更新日期:2001-01-01 00:00:00
abstract::Twelve surgical specimens of adrenal tumors (3 mainly compact cell adenomas and 2 mainly spongiocytic adenomas of Cushing's syndrome, 4 adenomas of Conn's syndrome, 1 androgen-secreting adenoma, and 2 hormonally inactive tumors) were studied by ultrastructural morphometry, using the point-counting method. All groups w...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915325
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. DESIGN:Twenty-two cases of DSV-PTC diagnosed between 1970 and 2...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:16:4:331
更新日期:2005-01-01 00:00:00
abstract::The association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is controversial. In this study, we aimed to compare preoperative thyroid functions, ultrasonography (US) features, fine-needle aspiration biopsy (FNAB) results, and histopathological characteristics of PTC in patients with and ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-015-9401-8
更新日期:2015-12-01 00:00:00
abstract::This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRA...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/s12022-016-9420-0
更新日期:2016-06-01 00:00:00
abstract::Synchronous occurrence of medullary and papillary carcinoma of the thyroid gland is very rare. We describe two cases of synchronous medullary and papillary carcinoma of the thyroid. In both cases, medullary carcinoma and papillary carcinoma were separate in the thyroid but mixed in some of the lymph node metastases. A...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1385/ep:15:1:83
更新日期:2004-04-01 00:00:00
abstract::The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02915332
更新日期:1991-06-01 00:00:00
abstract::In order to characterize the pattern of expression of carbohydrate structures in several types of thyroid tissues and to evaluate the putative usefulness of the detection of such antigens in diagnostic surgical pathology, we undertook the immunohistochemical study of simple mucin type antigens (T, Tn, and sialyl Tn), ...
journal_title:Endocrine pathology
pub_type: 杂志文章
doi:10.1007/BF02739836
更新日期:1996-01-01 00:00:00