Abstract：
:A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneous mass that was not FDG avid. Because of concern for adrenal cortical carcinoma, the patient underwent a successful right adrenalectomy. Pathology examination demonstrated an 11-cm circumscribed mass consisting of uniform spindle cells without nuclear pleomorphism, necrosis, or mitotic activity. The diagnosis of leiomyoma was supported by a panel of immunohistochemical stains. Adrenal leiomyomas have been reported in the literature, although most are small and not preoperatively suspicious for malignancy. This case illustrates that benign tumors such as leiomyomas, when large and heterogeneous on imaging, can clinically mimic adrenal cortical carcinomas and should be included in the differential diagnosis of adrenal incidentalomas.
journal_name
Endocr Patholjournal_title
Endocrine pathologyauthors
Lin J,Wasco MJ,Korobkin M,Doherty G,Giordano TJdoi
10.1007/s12022-008-9013-7subject
Has Abstractpub_date
2007-01-01 00:00:00pages
239-43issue
4eissn
1046-3976issn
1559-0097journal_volume
18pub_type
杂志文章abstract：:Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recen...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:17:1:53
更新日期：2006-04-01 00:00:00
abstract：:Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a r...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9471-x
更新日期：2017-03-01 00:00:00
abstract：:High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9516-9
更新日期：2018-09-01 00:00:00
abstract：:The diagnosis of pituitary corticotroph adenoma relies on the demonstration of a loss of the normal feedback control of adrenocorticotropic hormone (ACTH) biosynthesis by cortisol. The marked variability in the degree of ACTH suppression by glucocorticoids in these tumors, however, greatly enhances the difficulty in d...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915332
更新日期：1991-06-01 00:00:00
abstract：:Solitary fibrous tumor was initially thought to be a pleura-based tumor. However, over the last two decades, its involvement in a variety of extrapleural sites gained recognition. Nonetheless, a primary involvement of the endocrine organs is rare, and in this report, we detail an instance where the tumor affected the ...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-010-9113-z
更新日期：2010-06-01 00:00:00
abstract：:Activating mutations of the receptor tyrosine kinase, ret, are associated with multiple endocrine neoplasia type 2A (MEN 2A). However, the mechanisms leading to tumor development are unclear. Glial-derived neurotrophic factor (GDNF) activates wild-type ret via interaction with a second receptor, GFR a-l. We have utili...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739692
更新日期：1998-01-01 00:00:00
abstract：:The objective of this study was to evaluate the risk of malignancy (ROM) associated with atypia of undetermined significance (AUS) and suspicious follicular neoplasm (SFN) core needle biopsy (CNB) categories after further sub-classification. Data from 2267 thyroid nodules evaluated by ultrasound-guided CNB, from Janua...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-019-9577-4
更新日期：2019-06-01 00:00:00
abstract：:Gastrointestinal and pancreatic neuroendocrine tumors originate from the cells of the diffuse endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown, and they are different in genetic composition from the gastrointestinal epithelial tumors. The current...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1007/s12022-007-9007-x
更新日期：2007-10-01 00:00:00
abstract：:Neoplastic plasma cell involvement of thyroid is an uncommon condition, and it may involve thyroid in multiple myeloma or solitary plasmacytoma. Its clinical and pathological features are not well understood. We present a rare case of synchronous thyroid involvement in plasma cell leukemia presenting as thyroid nodule...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-015-9392-5
更新日期：2015-12-01 00:00:00
abstract：:Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear feature...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-007-9002-2
更新日期：2008-04-01 00:00:00
abstract：:Recent advances in molecular pathology have shed light not only on the cellular composition and derivation of various tumors, but also on their growth potential, likelihood of recurrence, and prognosis. The development of reliable and prognostically informative methods of assessing tumor behavior is particularly impor...
journal_title：Endocrine pathology
pub_type： 杂志文章,评审
doi：10.1385/ep:16:1:001
更新日期：2005-04-01 00:00:00
abstract：:Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary th...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-018-9549-0
更新日期：2018-12-01 00:00:00
abstract：:Hashimoto's thyroiditis is the archetype of organ-specific autoimmune disease. The key pathogenetic feature is the activation of thyroid-specific T-cells by properly presented endogenous thyroid antigens. There is strong indication that thyrocytes themselves present self-antigens, based on the finding of antigen prese...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739959
更新日期：1998-10-01 00:00:00
abstract：:Gain-of-function germline mutations of the RET proto-oncogene are responsible for initiation of carcinogenesis within the thyroid gland and development of hereditary form of medullary thyroid carcinoma and MEN2 syndrome. Genotype-phenotype correlations are established for most RET mutations, but the importance of the ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-017-9487-2
更新日期：2017-09-01 00:00:00
abstract：:The functional differentiation of pituitary cells and adenomas follows the combination of transcription factors and co-factors in three cell lineages [growth hormone-prolactin-thyroid-stimulating hormone lineage, adrenocorticotrophic hormone (ACTH)/pro-opiomelanocortin (POMC) lineage, and follicular stimulating hormon...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9014-6
更新日期：2008-04-01 00:00:00
abstract：:Nonradioisotopic electron microscopic (EM) in situ hybridization (ISH) (EM-SH) with biotinylated oligonucleotide probes is utilized for the ultrastructural visualization of pituitary hormone mRNA in rat pituitary cells. EMISH is an important tool for clarifying the intracellular localization of mRNA and the exact site...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02738881
更新日期：1999-10-01 00:00:00
abstract：:Insulin-like growth factor (IGF)-l and IGF-ll peptides as well as their mRNAs are produced in many organs, including the pituitary. Although IGFl and IGFII peptides are localized in endocrine cells of the anterior pituitary, IGF-l mRNA can be detected throughout the adenohypophysis, and IGF-ll mRNA is abundant in inte...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02738783
更新日期：1997-10-01 00:00:00
abstract：:Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the thyroid tissue revealed no thyroid peroxidase (TPO) activity...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739706
更新日期：1997-04-01 00:00:00
abstract：:The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately differentiated (grades II and Ill) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry and in situ hybridization. The tumors were divided into three groups based o...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739950
更新日期：1998-04-01 00:00:00
abstract：:Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02915391
更新日期：1990-09-01 00:00:00
abstract：:Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors. In some cases, demonstration of the primary tumor is ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-008-9024-4
更新日期：2008-10-01 00:00:00
abstract：:Hurthle cell carcinoma of the thyroid is generally considered to be a subtype of follicular carcinoma. We report a case of a small solitary usual-type papillary carcinoma of the thyroid, with metastatic tumor in cervical lymph nodes. The lymph node tumor consisted of both tall-cell papillary carcinoma and Hurthle cell...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-002-0002-y
更新日期：2002-10-01 00:00:00
abstract：:Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACT...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-012-9197-8
更新日期：2012-06-01 00:00:00
abstract：:Approximately 90% of neoplasms found in the sellar region are adenoma of the pituitary gland. The use of frozen sections for the diagnosis of pituitary adenomas has an accuracy of 90% and is useful in evaluating complete tumor removal. However, it is sometimes difficult to diagnose pituitary adenomas using frozen sect...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-015-9370-y
更新日期：2015-05-01 00:00:00
abstract：:Tissue sections from 50 cases with thyroid tumors, composed of 11 follicular adenomas, 10 follicular carcinomas, 14 papillary carcinomas, 10 anaplastic carcinomas, and 5 medullary carcinomas, were immunohistochemically analyzed for representative neuroendocrine markers. Immunoexpression ratios of these neuroendocrine ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:12:3:291
更新日期：2001-10-01 00:00:00
abstract：:Hyperparathyroidism is caused mainly by three different conditions: namely, secondary hyperplasia, primary hyperplasia, and adenoma with only a few cases due to carcinomas. Histological distinction among these diseases is still difficult. In an attempt to characterize the three conditions, 17 cases from patients with ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02739877
更新日期：1995-07-01 00:00:00
abstract：:Nodular corticotrope hyperplasia is a rare pathology causing Cushing's syndrome owing to a primary pituitary disease or ectopic CRH production. In this study, we evaluated the laboratory and pathological findings and results of transsphenoidal pituitary surgery in four patients with Cushing's disease. Dynamic tests of...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/BF02914989
更新日期：1995-04-01 00:00:00
abstract：:Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9466-z
更新日期：2017-03-01 00:00:00
abstract：:This study compared the expression profile of HBME-1 and claudin-1 in 90 papillary thyroid carcinomas (PTCs) with respect to the tumor architecture and invasive growth as reflected in 46 BRAF-like, 31 non-invasive RAS, and 13 invasive RAS-like phenotypes. Individual tumors were given an expression score (max 300) by m...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1007/s12022-016-9433-8
更新日期：2016-09-01 00:00:00
abstract：:The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequ...
journal_title：Endocrine pathology
pub_type： 杂志文章
doi：10.1385/ep:13:4:321
更新日期：2002-01-01 00:00:00
