Abstract:
:Activation of Wnt/β-catenin signaling can induce both self-renewal and differentiation in naive pluripotent embryonic stem cells (ESCs). To gain insights into the mechanism by which Wnt/β-catenin regulates ESC fate, we screened and characterized its downstream targets. Here, we show that the self-renewal-promoting effect of Wnt/β-catenin signaling is mainly mediated by two of its downstream targets, Klf2 and Tfcp2l1. Forced expression of Klf2 and Tfcp2l1 can not only induce reprogramming of primed state pluripotency into naive state ESCs, but also is sufficient to maintain the naive pluripotent state of ESCs. Conversely, downregulation of Klf2 and Tfcp2l1 impairs ESC self-renewal mediated by Wnt/β-catenin signaling. Our study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/β-catenin signaling.
journal_name
Stem Cell Reportsjournal_title
Stem cell reportsauthors
Qiu D,Ye S,Ruiz B,Zhou X,Liu D,Zhang Q,Ying QLdoi
10.1016/j.stemcr.2015.07.014subject
Has Abstractpub_date
2015-09-08 00:00:00pages
314-22issue
3issn
2213-6711pii
S2213-6711(15)00220-9journal_volume
5pub_type
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journal_title:Stem cell reports
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journal_title:Stem cell reports
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
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journal_title:Stem cell reports
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
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journal_title:Stem cell reports
pub_type: 杂志文章
doi:10.1016/j.stemcr.2014.06.002
更新日期:2014-08-12 00:00:00
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journal_title:Stem cell reports
pub_type: 杂志文章
doi:10.1016/j.stemcr.2018.12.003
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journal_title:Stem cell reports
pub_type: 杂志文章
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更新日期:2016-10-11 00:00:00
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journal_title:Stem cell reports
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
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journal_title:Stem cell reports
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
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journal_title:Stem cell reports
pub_type: 杂志文章
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