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Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells.

Abstract：

:Understanding the cellular properties controlling neural stem and progenitor cell (NSPC) fate choice will improve their therapeutic potential. The electrophysiological measure whole-cell membrane capacitance reflects fate bias in the neural lineage but the cellular properties underlying membrane capacitance are poorly understood. We tested the hypothesis that cell surface carbohydrates contribute to NSPC membrane capacitance and fate. We found NSPCs differing in fate potential express distinct patterns of glycosylation enzymes. Screening several glycosylation pathways revealed that the one forming highly branched N-glycans differs between neurogenic and astrogenic populations of cells in vitro and in vivo. Enhancing highly branched N-glycans on NSPCs significantly increases membrane capacitance and leads to the generation of more astrocytes at the expense of neurons with no effect on cell size, viability, or proliferation. These data identify the N-glycan branching pathway as a significant regulator of membrane capacitance and fate choice in the neural lineage.

journal_name

Stem Cell Reports

journal_title

Stem cell reports

authors

Yale AR,Nourse JL,Lee KR,Ahmed SN,Arulmoli J,Jiang AYL,McDonnell LP,Botten GA,Lee AP,Monuki ES,Demetriou M,Flanagan LA

doi

10.1016/j.stemcr.2018.08.011

subject

Has Abstract

pub_date

2018-10-09 00:00:00

pages

869-882

issue

4

issn

2213-6711

pii

S2213-6711(18)30355-2

journal_volume

11

pub_type

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