Abstract:
:Several studies have reported an association between the farnesoid X receptor alpha (FXRα) and estrogenic signaling pathways. Fxrα could thus be involved in the reprotoxic effects of endocrine disruptors such as bisphenol-A (BPA). To test this hypothesis, mice were exposed to BPA and/or stigmasterol (S), an FXRα antagonist. Following the exposure to both molecules, wild-type animals showed impaired fertility and lower sperm cell production associated with the alteration of the establishment and maintenance of the undifferentiated germ cell pool. The crosstalk between BPA and FXRα is further supported by the lower impact of BPA in mice genetically ablated for Fxrα and the fact that BPA counteracted the effects of FXRα agonists. These effects might result from the downregulation of Fxrα expression following BPA exposure. BPA and S act additively in human testis. Our data demonstrate that FXRα activity modulates the impact of BPA on male gonads and on undifferentiated germ cell population.
journal_name
Stem Cell Reportsjournal_title
Stem cell reportsauthors
Sèdes L,Desdoits-Lethimonier C,Rouaisnel B,Holota H,Thirouard L,Lesne L,Damon-Soubeyrand C,Martinot E,Saru JP,Mazaud-Guittot S,Caira F,Beaudoin C,Jégou B,Volle DHdoi
10.1016/j.stemcr.2018.08.018subject
Has Abstractpub_date
2018-10-09 00:00:00pages
944-958issue
4issn
2213-6711pii
S2213-6711(18)30362-Xjournal_volume
11pub_type
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