听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Stem Cell Reports期刊下所有文献
  • Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures.

    abstract::Organoids (ORGs) are increasingly used as models of cerebral cortical development. Here, we compared transcriptome and cellular phenotypes between telencephalic ORGs and monolayers (MONs) generated in parallel from three biologically distinct induced pluripotent stem cell (iPSC) lines. Multiple readouts revealed incre...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.12.019

    authors: Scuderi S,Altobelli GG,Cimini V,Coppola G,Vaccarino FM

    更新日期:2021-01-20 00:00:00

  • A Genetic Screen Identifies Etl4-Deficiency Capable of Stabilizing the Haploidy in Embryonic Stem Cells.

    abstract::Mammalian haploid embryonic stem cells (haESCs) hold great promise for functional genetic studies and forward screening. However, all established haploid cells are prone to spontaneous diploidization during long-term culture, rendering application challenging. Here, we report a genome-wide loss-of-function screening t...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.11.016

    authors: Zhang G,Li X,Sun Y,Wang X,Liu G,Huang Y

    更新日期:2021-01-12 00:00:00

  • Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells.

    abstract::Microglia have recently been established as key regulators of brain development. However, their role in neuronal subtype specification remains largely unknown. Using three different co-culture setups, we show that microglia-secreted factors enhance dopaminergic differentiation of somatic and induced pluripotent stem c...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.12.011

    authors: Schmidt SI,Bogetofte H,Ritter L,Agergaard JB,Hammerich D,Kabiljagic AA,Wlodarczyk A,Lopez SG,Sørensen MD,Jørgensen ML,Okarmus J,Serrano AM,Kristensen BW,Freude K,Owens T,Meyer M

    更新日期:2021-01-06 00:00:00

  • Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation.

    abstract::The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes. Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis. Compensatory mechanisms to regulate the intracellular bile acid concentration in human hepatocytes with BSEP deficiency ...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.12.008

    authors: Hayashi H,Osaka S,Sakabe K,Fukami A,Kishimoto E,Aihara E,Sabu Y,Mizutani A,Kusuhara H,Naritaka N,Zhang W,Huppert SS,Sakabe M,Nakamura T,Hu YC,Mayhew C,Setchell K,Takebe T,Asai A

    更新日期:2020-12-30 00:00:00

  • Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons.

    abstract::Direct reprogramming has been widely explored to generate various types of neurons for neurobiological research and translational medicine applications, but there is still no efficient reprogramming method to generate retinal ganglion cell (RGC)-like neurons, which are the sole projection neurons in the retina. Here, ...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.09.008

    authors: Wang J,He Q,Zhang K,Sun H,Zhang G,Liang H,Guo J,Hao L,Ke J,Chen S

    更新日期:2020-11-10 00:00:00

  • Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells.

    abstract::Cell transplantation into immunodeficient recipients is a widely used approach to study stem cell and cancer biology; however, studying cell states post transplantation in vivo is inconvenient in mammals. Here, we generated a foxn1/Casper mutant zebrafish that is transparent and exhibits T cell deficiency. By employin...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.07.020

    authors: Lv P,Ma D,Gao S,Zhang Y,Bae YK,Liang G,Gao S,Choi JH,Kim CH,Wang L,Liu F

    更新日期:2020-09-08 00:00:00

  • Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures.

    abstract::Direct cardiac reprogramming holds great potential for regenerative medicine. However, it remains inefficient, and induced cardiomyocytes (iCMs) generated in vitro are less mature than those in vivo, suggesting that undefined extrinsic factors may regulate cardiac reprogramming. Previous in vitro studies mainly used h...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.07.022

    authors: Kurotsu S,Sadahiro T,Fujita R,Tani H,Yamakawa H,Tamura F,Isomi M,Kojima H,Yamada Y,Abe Y,Murakata Y,Akiyama T,Muraoka N,Harada I,Suzuki T,Fukuda K,Ieda M

    更新日期:2020-09-08 00:00:00

  • FAM122A Inhibits Erythroid Differentiation through GATA1.

    abstract::FAM122A is a highly conserved housekeeping gene, but its physiological and pathophysiological roles remain greatly elusive. Based on the fact that FAM122A is highly expressed in human CD71+ early erythroid cells, herein we report that FAM122A is downregulated during erythroid differentiation, while its overexpression ...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.07.010

    authors: Chen J,Zhou Q,Liu MH,Yang YS,Wang YQ,Huang Y,Chen GQ

    更新日期:2020-09-08 00:00:00

  • GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation.

    abstract::Transcriptome analysis has uncovered a series of long noncoding RNAs (lncRNAs) transcribed during cell differentiation, but how lncRNA is integrated with known transcriptional regulatory network is poorly understood. Here, we utilize human definitive endoderm differentiation as a model system and decipher the function...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.07.014

    authors: Yang J,Lu P,Li M,Yan C,Zhang T,Jiang W

    更新日期:2020-09-08 00:00:00

  • A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types.

    abstract::The transcription factor (TF) GATA2 plays a key role in organ development and cell fate control in the central nervous, urogenital, respiratory, and reproductive systems, and in primitive and definitive hematopoiesis. Here, we generate a knockin protein reporter mouse line expressing a GATA2VENUS fusion from the endog...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.06.008

    authors: Ahmed N,Kunz L,Hoppe PS,Loeffler D,Etzrodt M,Ortega GC,Hilsenbeck O,Anastassiadis K,Schroeder T

    更新日期:2020-08-11 00:00:00

  • The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.

    abstract::We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult hematopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs in fetal liver (FL) due to faster proliferation. Systemic deleti...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.06.022

    authors: Biswas A,Roy IM,Babu PC,Manesia J,Schouteden S,Vijayakurup V,Anto RJ,Huelsken J,Lacy-Hulbert A,Verfaillie CM,Khurana S

    更新日期:2020-08-11 00:00:00

  • In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment.

    abstract::Neurons differentiated from induced pluripotent stem cells (iPSCs) typically show regular spiking and synaptic activity but lack more complex network activity critical for brain development, such as periodic depolarizations including simultaneous involvement of glutamatergic and GABAergic neurotransmission. We generat...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.05.015

    authors: Rosa F,Dhingra A,Uysal B,Mendis GDC,Loeffler H,Elsen G,Mueller S,Schwarz N,Castillo-Lizardo M,Cuddy C,Becker F,Heutink P,Reid CA,Petrou S,Lerche H,Maljevic S

    更新日期:2020-07-14 00:00:00

  • Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition.

    abstract::Intestinal crypts have great capacity for repair and regeneration after intestinal stem cell (ISC) injury. Here, we define the cellular remodeling process resulting from ISC niche interruption by transient Notch pathway inhibition in adult mice. Although ISCs were retained, lineage tracing demonstrated a marked reduct...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.05.010

    authors: Bohin N,Keeley TM,Carulli AJ,Walker EM,Carlson EA,Gao J,Aifantis I,Siebel CW,Rajala MW,Myers MG Jr,Jones JC,Brindley CD,Dempsey PJ,Samuelson LC

    更新日期:2020-07-14 00:00:00

  • Developmental IL-6 Exposure Favors Production of PDGF-Responsive Multipotential Progenitors at the Expense of Neural Stem Cells and Other Progenitors.

    abstract::Interleukin-6 (IL-6) is increased in maternal serum and amniotic fluid of children subsequently diagnosed with autism spectrum disorders. However, it is not clear how increased IL-6 alters brain development. Here, we show that IL-6 increases the prevalence of a specific platelet-derived growth factor (PDGF)-responsive...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.03.019

    authors: Kumari E,Velloso FJ,Nasuhidehnavi A,Somasundaram A,Savanur VH,Buono KD,Levison SW

    更新日期:2020-05-12 00:00:00

  • Memory of Divisional History Directs the Continuous Process of Primitive Hematopoietic Lineage Commitment.

    abstract::Hematopoietic stem cells (HSCs) exist in a dormant state and progressively lose regenerative potency as they undergo successive divisions. Why this functional decline occurs and how this information is encoded is unclear. To better understand how this information is stored, we performed RNA sequencing on HSC populatio...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.03.005

    authors: Bernitz JM,Rapp K,Daniel MG,Shcherbinin D,Yuan Y,Gomes A,Waghray A,Brosh R,Lachmann A,Ma'ayan A,Papatsenko D,Moore KA

    更新日期:2020-04-14 00:00:00

  • Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium.

    abstract::ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. It is expressed in hematopoietic tissue during embryonic development, but its function was unknown. Zebrafish arl4aa is preferentially expressed in the ventral wall of the dorsal aorta (VDA) at 24 and 36 hpf and in caudal hema...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.02.012

    authors: Guo Y,Cheng BYL,Wang D,Ma ACH,He BL,Man TK,Cheung MPL,Shi X,Ng NKL,Leung AYH

    更新日期:2020-04-14 00:00:00

  • Transgenesis and Genome Editing of Mouse Spermatogonial Stem Cells by Lentivirus Pseudotyped with Sendai Virus F Protein.

    abstract::Spermatogonial stem cells (SSCs) serve as a resource for producing genetically modified animals. However, genetic manipulation of SSCs has met with limited success. Here, we show efficient gene transfer into SSCs via a lentivirus (FV-LV) using a fusion protein (F), a Sendai virus (SV) envelope protein involved in viri...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.02.001

    authors: Shinohara T,Kanatsu-Shinohara M

    更新日期:2020-03-10 00:00:00

  • Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture.

    abstract::Human induced pluripotent stem cell (hiPSC) culture has become routine, yet the cost of pluripotent cell media, frequent medium changes, and the reproducibility of differentiation have remained restrictive. Here, we describe the formulation of a hiPSC culture medium (B8) as a result of the exhaustive optimization of m...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.12.007

    authors: Kuo HH,Gao X,DeKeyser JM,Fetterman KA,Pinheiro EA,Weddle CJ,Fonoudi H,Orman MV,Romero-Tejeda M,Jouni M,Blancard M,Magdy T,Epting CL,George AL Jr,Burridge PW

    更新日期:2020-02-11 00:00:00

  • Sox100B Regulates Progenitor-Specific Gene Expression and Cell Differentiation in the Adult Drosophila Intestine.

    abstract::Robust production of terminally differentiated cells from self-renewing resident stem cells is essential to maintain proper tissue architecture and physiological functions, especially in high-turnover tissues. However, the transcriptional networks that precisely regulate cell transition and differentiation are poorly ...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.01.003

    authors: Meng FW,Rojas Villa SE,Biteau B

    更新日期:2020-02-11 00:00:00

  • Cancer Stem Cells: Notes for Authors.

    abstract::Stem Cell Reports frequently receives manuscripts dealing with the topic of cancer stem cells. Many of the submissions on this topic have major shortcomings in their content or limits to the conclusions that can be drawn from the results presented. The purpose of this Commentary is to highlight some of the underlying ...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2020.01.011

    authors: Eaves CJ,Pera MF

    更新日期:2020-02-11 00:00:00

  • LIN28B Impairs the Transition of hESC-Derived β Cells from the Juvenile to Adult State.

    abstract::Differentiation of human embryonic stem cells into pancreatic β cells holds great promise for the treatment of diabetes. Recent advances have led to the production of glucose-responsive insulin-secreting cells in vitro, but resulting cells remain less mature than their adult primary β cell counterparts. The barrier(s)...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.11.009

    authors: Zhou X,Nair GG,Russ HA,Belair CD,Li ML,Shveygert M,Hebrok M,Blelloch R

    更新日期:2020-01-14 00:00:00

  • A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.

    abstract::Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal loba...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.09.006

    authors: Karch CM,Kao AW,Karydas A,Onanuga K,Martinez R,Argouarch A,Wang C,Huang C,Sohn PD,Bowles KR,Spina S,Silva MC,Marsh JA,Hsu S,Pugh DA,Ghoshal N,Norton J,Huang Y,Lee SE,Seeley WW,Theofilas P,Grinberg LT,Moreno F

    更新日期:2019-11-12 00:00:00

  • Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain.

    abstract::Human pluripotent stem cells are a valuable resource for transplantation, yet our ability to profile xenografts is largely limited to low-throughput immunohistochemical analysis by difficulties in readily isolating grafts for transcriptomic and/or proteomic profiling. Here, we present a simple methodology utilizing di...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.10.001

    authors: Bye CR,Penna V,de Luzy IR,Gantner CW,Hunt CPJ,Thompson LH,Parish CL

    更新日期:2019-11-12 00:00:00

  • Targeted Repair of p47-CGD in iPSCs by CRISPR/Cas9: Functional Correction without Cleavage in the Highly Homologous Pseudogenes.

    abstract::Mutations in the NADPH oxidase, which is crucial for the respiratory burst in phagocytes, result in chronic granulomatous disease (CGD). The only curative treatment option for CGD patients, who suffer from severe infections, is allogeneic bone marrow transplantation. Over 90% of patients with mutations in the p47phox ...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.08.008

    authors: Klatt D,Cheng E,Philipp F,Selich A,Dahlke J,Schmidt RE,Schott JW,Büning H,Hoffmann D,Thrasher AJ,Schambach A

    更新日期:2019-10-08 00:00:00

  • Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance.

    abstract::The environment surrounding stem cells has the ability to elicit profound, heritable epigenetic changes orchestrated by multiple epigenetic mechanisms, which can be modulated by the level of specific metabolites. In this review, we highlight the significance of metabolism in regulating stem cell homeostasis, cell stat...

    journal_title:Stem cell reports

    pub_type: 杂志文章,评审

    doi:10.1016/j.stemcr.2019.09.003

    authors: Harvey A,Caretti G,Moresi V,Renzini A,Adamo S

    更新日期:2019-10-08 00:00:00

  • Characterizing Direct-to-Consumer Stem Cell Businesses in the Southwest United States.

    abstract::There are currently hundreds of businesses across the United States offering direct-to-consumer stem cell treatments that have not been through regulatory approval by the Food and Drug Administration (FDA). Here, we provide a detailed characterization of nearly 170 stem cell businesses operating in the Southwest Unite...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.07.001

    authors: Frow EK,Brafman DA,Muldoon A,Krum L,Williams P,Becker B,Nelson JP,Pritchett A

    更新日期:2019-08-13 00:00:00

  • Origins of Neural Progenitor Cell-Derived Axons Projecting Caudally after Spinal Cord Injury.

    abstract::Neural progenitor cells (NPCs) transplanted into sites of spinal cord injury (SCI) extend large numbers of axons into the caudal host spinal cord. We determined the precise locations of neurons in the graft that extend axons into the caudal host spinal cord using AAV9-Cre-initiated retrograde tracing into floxed-TdTom...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.05.011

    authors: Lu P,Gomes-Leal W,Anil S,Dobkins G,Huie JR,Ferguson AR,Graham L,Tuszynski M

    更新日期:2019-07-09 00:00:00

  • Chemically Defined Media Can Maintain Pig Pluripotency Network In Vitro.

    abstract::Pig embryonic stem cells (pESCs) have been considered an important candidate for preclinical research on human therapies. However, the lack of understanding of pig pluripotent networks has hampered establishment of authentic pESCs. Here, we report that FGF2, ACTVIN, and WNT signaling are essential to sustain pig pluri...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.05.028

    authors: Choi KH,Lee DK,Kim SW,Woo SH,Kim DY,Lee CK

    更新日期:2019-07-09 00:00:00

  • A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia.

    abstract::Contractile to synthetic phenotypic switching of smooth muscle cells (SMCs) contributes to stenosis in vascular disease and vascular transplants. To generate more contractile SMCs, we performed a high-throughput differentiation screen using a MYH11-NLuc-tdTomato human embryonic stem cell reporter cell line. We identif...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.04.013

    authors: Zhang J,McIntosh BE,Wang B,Brown ME,Probasco MD,Webster S,Duffin B,Zhou Y,Guo LW,Burlingham WJ,Kent C,Ferris M,Thomson JA

    更新日期:2019-06-11 00:00:00

  • Functional Properties of Engineered Heart Slices Incorporating Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

    abstract::Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for cardiac studies, but their structural and functional immaturity precludes their use as faithful models of adult myocardium. Here we describe engineered heart slices (EHS), preparations of decellularized porcine myocardium rep...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.04.002

    authors: Blazeski A,Lowenthal J,Zhu R,Ewoldt J,Boheler KR,Tung L

    更新日期:2019-05-14 00:00:00

  • Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.

    abstract::Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a crucial cofactor in its etiology. Here, we show that PD patient-specific human neuroepithelial stem cells (...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.03.004

    authors: Walter J,Bolognin S,Antony PMA,Nickels SL,Poovathingal SK,Salamanca L,Magni S,Perfeito R,Hoel F,Qing X,Jarazo J,Arias-Fuenzalida J,Ignac T,Monzel AS,Gonzalez-Cano L,Pereira de Almeida L,Skupin A,Tronstad KJ,Schwamborn

    更新日期:2019-05-14 00:00:00

  • Adult Neural Progenitor Cells Transplanted into Spinal Cord Injury Differentiate into Oligodendrocytes, Enhance Myelination, and Contribute to Recovery.

    abstract::Long-term survival and integration of neural progenitor cells (NPCs) transplanted following spinal cord injury (SCI) have been observed. However, questions concerning the differentiation choice, the mechanism of action, and the contribution of NPCs to functional recovery remains unanswered. Therefore, we investigated ...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.03.013

    authors: Sankavaram SR,Hakim R,Covacu R,Frostell A,Neumann S,Svensson M,Brundin L

    更新日期:2019-05-14 00:00:00

  • Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development.

    abstract::The neural crest (NC) gives rise to a multitude of fetal tissues, and its misregulation is implicated in congenital malformations. Here, we investigated molecular mechanisms pertaining to NC-related symptoms in Bohring-Opitz syndrome (BOS), a developmental disorder linked to mutations in the Polycomb group factor Addi...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.03.006

    authors: Matheus F,Rusha E,Rehimi R,Molitor L,Pertek A,Modic M,Feederle R,Flatley A,Kremmer E,Geerlof A,Rishko V,Rada-Iglesias A,Drukker M

    更新日期:2019-05-14 00:00:00

  • Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation.

    abstract::Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved. Here we show that platelets are activated after acute periods of running, and that activated plate...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2019.02.009

    authors: Leiter O,Seidemann S,Overall RW,Ramasz B,Rund N,Schallenberg S,Grinenko T,Wielockx B,Kempermann G,Walker TL

    更新日期:2019-04-09 00:00:00

  • Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression.

    abstract::Although pluripotent stem cells can generate various types of differentiated cells, it is unclear why lineage-committed stem/progenitor cells derived from pluripotent stem cells are decelerated and why the differentiation-resistant propensity of embryonic stem cell (ESC)/induced pluripotent stem cell (iPSC)-derived ce...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2018.12.018

    authors: Nishihara K,Shiga T,Nakamura E,Akiyama T,Sasaki T,Suzuki S,Ko MSH,Tada N,Okano H,Akamatsu W

    更新日期:2019-02-12 00:00:00

  • Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network.

    abstract::Reappraisal of neuropathological studies suggests that pathological hallmarks of Alzheimer's disease and Parkinson's disease (PD) spread progressively along predictable neuronal pathways in the human brain through unknown mechanisms. Although there is much evidence supporting the prion-like propagation and amplificati...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2018.12.007

    authors: Gribaudo S,Tixador P,Bousset L,Fenyi A,Lino P,Melki R,Peyrin JM,Perrier AL

    更新日期:2019-02-12 00:00:00

  • GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation.

    abstract::Heterozygous de novo mutations in GATA6 are the most frequent cause of pancreatic agenesis in humans. In mice, however, a similar phenotype requires the biallelic loss of Gata6 and its paralog Gata4. To elaborate the human-specific requirements for GATA6, we chose to model GATA6 loss in vitro by combining both gene-ed...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2018.12.003

    authors: Chia CY,Madrigal P,Denil SLIJ,Martinez I,Garcia-Bernardo J,El-Khairi R,Chhatriwala M,Shepherd MH,Hattersley AT,Dunn NR,Vallier L

    更新日期:2019-01-08 00:00:00

  • A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations.

    abstract::Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disorder of heart muscle thickening associated with sudden cardiac death and heart failure, with unclear mechanisms. We engineered four isogenic induced pluripotent stem cell (iPSC) models of β-myosin heavy chain and myosin-b...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2018.11.015

    authors: Cohn R,Thakar K,Lowe A,Ladha FA,Pettinato AM,Romano R,Meredith E,Chen YS,Atamanuk K,Huey BD,Hinson JT

    更新日期:2019-01-08 00:00:00

  • Engineered Microenvironment for Manufacturing Human Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells.

    abstract::Human pluripotent stem cell-derived vascular smooth muscle cells (hPSC-VSMCs) are of great value for disease modeling, drug screening, cell therapies, and tissue engineering. However, producing a high quantity of hPSC-VSMCs with current cell culture technologies remains very challenging. Here, we report a scalable met...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2018.11.009

    authors: Lin H,Qiu X,Du Q,Li Q,Wang O,Akert L,Wang Z,Anderson D,Liu K,Gu L,Zhang C,Lei Y

    更新日期:2019-01-08 00:00:00

  • The MicroRNA-371 Family as Plasma Biomarkers for Monitoring Undifferentiated and Potentially Malignant Human Pluripotent Stem Cells in Teratoma Assays.

    abstract::Predicting developmental potency and risk of posttransplantation tumor formation by human pluripotent stem cells (hPSCs) and their derivatives largely rely on classical histological analysis of teratomas. Here, we investigated whether an assay based on microRNAs (miRNA) in blood plasma is able to detect potentially ma...

    journal_title:Stem cell reports

    pub_type: 杂志文章

    doi:10.1016/j.stemcr.2018.11.002

    authors: Salvatori DCF,Dorssers LCJ,Gillis AJM,Perretta G,van Agthoven T,Gomes Fernandes M,Stoop H,Prins JB,Oosterhuis JW,Mummery C,Looijenga LHJ

    更新日期:2018-12-11 00:00:00

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