当前位置： SCI文献检索 > Stem Cell Reports期刊下所有文献 > ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells.

ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells.

Abstract：

:Properties of cancer stem cells involved in drug resistance and relapse have significant effects on clinical outcome. Although tyrosine kinase inhibitors (TKIs) have dramatically improved survival of patients with chronic myeloid leukemia (CML), TKIs have not fully cured CML due to TKI-resistant CML stem cells. Moreover, relapse after discontinuation of TKIs has not been predicted in CML patients with the best TKI response. In our study, a model of CML stem cells derived from CML induced pluripotent stem cells identified ADAM8 as an antigen of TKI-resistant CML cells. The inhibition of expression or metalloproteinase activity of ADAM8 restored TKI sensitivity in primary samples. In addition, residual CML cells in patients with optimal TKI response were concentrated in the ADAM8+ population. Our study demonstrates that ADAM8 is a marker of residual CML cells even in patients with optimal TKI response and would be a predictor of relapse and a therapeutic target of TKI-resistant CML cells.

journal_name

Stem Cell Reports

journal_title

Stem cell reports

authors

Miyauchi M,Koya J,Arai S,Yamazaki S,Honda A,Kataoka K,Yoshimi A,Taoka K,Kumano K,Kurokawa M

doi

10.1016/j.stemcr.2018.01.015

subject

Has Abstract

pub_date

2018-03-13 00:00:00

pages

1115-1130

issue

3

issn

2213-6711

pii

S2213-6711(18)30041-9

journal_volume

10

pub_type

杂志文章

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