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Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation.

Abstract：

:Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved. Here we show that platelets are activated after acute periods of running, and that activated platelets promote neurogenesis, an effect that is likely mediated by platelet factor 4. Ex vivo, the beneficial effects of activated platelets and platelet factor 4 on neural precursor cells were dentate gyrus specific and not observed in the subventricular zone. Moreover, the depletion of circulating platelets in mice abolished the running-induced increase in precursor cell proliferation in the dentate gyrus following exercise. These findings demonstrate that platelets and their released factors can modulate adult neural precursor cells under physiological conditions and provide an intriguing link between running-induced platelet activation and the modulation of neurogenesis after exercise.

journal_name

Stem Cell Reports

journal_title

Stem cell reports

authors

Leiter O,Seidemann S,Overall RW,Ramasz B,Rund N,Schallenberg S,Grinenko T,Wielockx B,Kempermann G,Walker TL

doi

10.1016/j.stemcr.2019.02.009

subject

Has Abstract

pub_date

2019-04-09 00:00:00

pages

667-679

issue

4

issn

2213-6711

pii

S2213-6711(19)30057-8

journal_volume

12

pub_type

杂志文章

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