Abstract:
:Long-term survival and integration of neural progenitor cells (NPCs) transplanted following spinal cord injury (SCI) have been observed. However, questions concerning the differentiation choice, the mechanism of action, and the contribution of NPCs to functional recovery remains unanswered. Therefore, we investigated the differentiation of NPCs, global transcriptomal changes in transplanted NPCs, the effect of NPCs on neuroinflammation, and the causality between NPC transplantation and functional recovery. We found that NPCs transplanted following SCI differentiate mainly into oligodendrocytes and enhance myelination, upregulate genes related to synaptic signaling and mitochondrial activity, and downregulate genes related to cytokine production and immune system response. NPCs suppress the expression of pro-inflammatory cytokines/chemokines; moreover, NPC ablation confirm that NPCs were responsible for enhanced recovery in hindlimb locomotor function. Understanding the reaction of transplanted NPCs is important for exploiting their full potential. Existence of causality implies that NPCs are useful in the treatment of SCI.
journal_name
Stem Cell Reportsjournal_title
Stem cell reportsauthors
Sankavaram SR,Hakim R,Covacu R,Frostell A,Neumann S,Svensson M,Brundin Ldoi
10.1016/j.stemcr.2019.03.013subject
Has Abstractpub_date
2019-05-14 00:00:00pages
950-966issue
5issn
2213-6711pii
S2213-6711(19)30098-0journal_volume
12pub_type
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
pub_type: 杂志文章
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journal_title:Stem cell reports
pub_type: 杂志文章
doi:10.1016/j.stemcr.2016.09.011
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journal_title:Stem cell reports
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