Abstract：
:Ischemic stroke enhances the proliferation of adult-generated precursor cells that ectopically migrate toward the infarct. Studies have correlated precursor cell proliferation and subsequent adult neurogenesis with enhanced stroke recovery, yet it remains unclear whether stroke can generate new neurons capable of functional integration into the injured cortex. Here, using single and bitransgenic reporter mice, we identify spatial and temporal features of a multilineage cellular response to focal ischemia. We reveal that a small population of stroke-induced immature neurons accumulate within the peri-infarct region of the adult sensorimotor cortex, exhibit voltage-dependent conductances, fire action potentials, express GABAergic markers, and receive sparse GABAergic synaptic inputs. Collectively, these findings reveal that GABAergic neurons arising from the lateral ventricle have the capacity to integrate into the stroke-injured cortex, although their limited number and exiguous synaptic integration may limit their ability to participate in stroke recovery.
journal_name
Stem Cell Reportsjournal_title
Stem cell reportsauthors
Kannangara TS,Carter A,Xue Y,Dhaliwal JS,Béïque JC,Lagace DCdoi
10.1016/j.stemcr.2018.10.011subject
Has Abstractpub_date
2018-12-11 00:00:00pages
1327-1336issue
6issn
2213-6711pii
S2213-6711(18)30434-Xjournal_volume
11pub_type
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