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Sox2-mediated regulation of adult neural crest precursors and skin repair.

Abstract：

:Nerve-derived neural crest cells are essential for regeneration in certain animals, such as newts. Here, we asked whether they play a similar role during mammalian tissue repair, focusing on Sox2-positive neural crest precursors in skin. In adult skin, Sox2 was expressed in nerve-terminal-associated neural crest precursor cells (NCPCs) around the hair follicle bulge, and following injury was induced in nerve-derived cells, likely dedifferentiated Schwann cell precursors. At later times postinjury, Sox2-positive cells were scattered throughout the regenerating dermis, and lineage tracing showed that these were all neural-crest-derived NCPCs. These Sox2-positive NCPCs were functionally important, since acute deletion of Sox2 prior to injury caused a decrease of NCPCs in the wound and aberrant skin repair. These data demonstrate that Sox2 regulates skin repair, likely by controlling NCPCs, and raise the possibility that nerve-derived NCPCs may play a general role in mammalian tissue repair.

journal_name

Stem Cell Reports

journal_title

Stem cell reports

authors

Johnston AP,Naska S,Jones K,Jinno H,Kaplan DR,Miller FD

doi

10.1016/j.stemcr.2013.04.004

subject

Has Abstract

pub_date

2013-06-04 00:00:00

pages

38-45

issue

1

issn

2213-6711

pii

S2213-6711(13)00011-8

journal_volume

1

pub_type

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