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Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium.

Abstract：

:ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. It is expressed in hematopoietic tissue during embryonic development, but its function was unknown. Zebrafish arl4aa is preferentially expressed in the ventral wall of the dorsal aorta (VDA) at 24 and 36 hpf and in caudal hematopoietic tissue at 48 hpf. Morpholino knockdown and transcription activator-like effector nuclease (TALEN) knockout of arl4aa significantly reduced expression of genes associated with definitive hematopoietic stem cells (HSCs). Golgi complex integrity in VDA was disrupted as shown by transmission electron microscopy and immunostaining of Golgi membrane Giantin. Mechanistically, arl4aa knockdown reduced Notch signaling in the VDA and its target gene expression. Protein expression of NICD was also reduced. Effects of arl4aa knockdown on definitive hematopoiesis could be restored by NICD expression. This study identified arl4aa as a factor regulating initiation of definitive HSCs by maintaining the integrity of Golgi complex and, secondarily, maturation of the Notch receptor.

journal_name

Stem Cell Reports

journal_title

Stem cell reports

authors

Guo Y,Cheng BYL,Wang D,Ma ACH,He BL,Man TK,Cheung MPL,Shi X,Ng NKL,Leung AYH

doi

10.1016/j.stemcr.2020.02.012

subject

Has Abstract

pub_date

2020-04-14 00:00:00

pages

575-589

issue

4

issn

2213-6711

pii

S2213-6711(20)30068-0

journal_volume

14

pub_type

杂志文章

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