Abstract:
:Previous histomorphometric studies led us to hypothesize that suppression of hepatocellular regeneration and the repair of the hepatolobular architecture was involved besides bioactivation phenomenon in the progressive and irreversible phase of toxicity resulting from CD + CCl4 interaction. We have recently observed significant protection from CD potentiated CCl4 toxicity in animals which are stimulated for active hepatocellular regeneration. The present work is an extension of our earlier histomorphometric investigation, taking 3H-thymidine (3H-T) incorporation as a biochemical parameter to assess hepatocellular regeneration followed by autoradiographic analysis of liver sections in normal (N) or chlordecone (CD) treated (10 ppm in diet for 15 days) male rats undergoing sham (SH) or partial hepatectomies (PH). Initial experiments established that in normal (N) rats, greatest 3H-T incorporation into hepatocellular nuclear DNA occurs at 2 days post-PH which returns to basal levels by 7 days. CD treatment alone did not change this phenomenon. 3H-T incorporation into nuclear DNA and the percentage of labelled cells as evidenced by autoradiography of liver sections were significantly elevated in N rats at 1-2 h after CCl4 (100 microliters/kg) administration and returned to basal level by 6 h. Serum enzymes (AST and ALT) in N rats undergoing SH and PH were not altered, but were significantly elevated in CD rats following CCl4 (100 microliters/kg) administration. CCl4-induced serum enzyme elevations were significantly lower in 2 days post-PH (PH2) rats when compared to SH rats or 7 days post-PH (PH7) rats maintained on CD diet, indicating that CD potentiated CCl4 hepatotoxicity is significantly reduced in livers stimulated for regenerative activity by PH.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Kodavanti PR,Joshi UM,Young RA,Bell AN,Mehendale HMdoi
10.1007/BF00303125subject
Has Abstractpub_date
1989-01-01 00:00:00pages
367-75issue
5eissn
0340-5761issn
1432-0738journal_volume
63pub_type
杂志文章abstract::Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to ne...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2040-8
更新日期:2017-11-01 00:00:00
abstract::Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1803-y
更新日期:2017-01-01 00:00:00
abstract::Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2259-z
更新日期:2018-09-01 00:00:00
abstract::Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1888-3
更新日期:2017-06-01 00:00:00
abstract::Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00296955
更新日期:1987-01-01 00:00:00
abstract::Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00286576
更新日期:1985-04-01 00:00:00
abstract::Aciclovir (synonym: acyclovir) causes abnormal thymus development in rats. After treatment on day 10 of gestation a weight reduction of the organ is obvious in 21-day-old fetuses which persists postnatally. Adult male rats exposed in utero to one or three injections of 100 mg aciclovir/kg body wt given to the dam on d...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973385
更新日期:1992-01-01 00:00:00
abstract::Chondrotoxicity is a rare toxicological finding which is observed in dogs after administration of quinolone antibacterials. To study this effect chondrocytes from articular cartilage of dogs were isolated, and incubated with quinolone derivatives. The effects on cell viability, mitochondrial dehydrogenase, and proteog...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01977402
更新日期:1993-01-01 00:00:00
abstract::The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1470-4
更新日期:2015-05-01 00:00:00
abstract::Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and de...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1633-3
更新日期:2015-12-01 00:00:00
abstract::In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100277
更新日期:2001-12-01 00:00:00
abstract::The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316327
更新日期:1986-10-01 00:00:00
abstract::A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00293571
更新日期:1976-06-08 00:00:00
abstract::The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has incr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1489-6
更新日期:2016-03-01 00:00:00
abstract::Overdose of acetaminophen (APAP) causes necrosis of centrilobular cells of the liver. Accumulating evidence suggests that innate immune system may contribute to APAP-induced hepatotoxicity. Interaction between RANTES and its receptor C-C chemokine receptor (CCR) 5 is related to recruitment of macrophages to sites of i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1253-3
更新日期:2015-02-01 00:00:00
abstract::Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050112
更新日期:1994-01-01 00:00:00
abstract::The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF03035706
更新日期:1994-01-01 00:00:00
abstract::Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1757-0
更新日期:2016-08-01 00:00:00
abstract::Free radical processes are proposed to play a crucial role in the development of procainamide adverse effects. Therefore, selenium, as a potent antioxidant, may modified procainamide toxicity. To test this hypothesis plasma and liver thiobarbituric acid-reacting substances (TBARS), plasma antioxidant activity (AOA), e...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973693
更新日期:1993-01-01 00:00:00
abstract::Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0109-x
更新日期:2006-12-01 00:00:00
abstract::Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353318
更新日期:1975-10-20 00:00:00
abstract::Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progression of AMD. The toxic fluorophore N-retinyl-N-retinylidene et...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02637-w
更新日期:2020-02-01 00:00:00
abstract::Changes in the electrophysiologic activity of the rat sciatic nerve were examined after repeated dosing with either of two organophosphate insecticides, parathion, and trichlorfon. Although the parathion treated animals showed overt signs of systemic toxicity, there were no significant changes in any of the measured p...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00333896
更新日期:1983-03-01 00:00:00
abstract::We studied the incorporation of cocaine (COC), benzoylecgonine (BE) and ecgonine methyl ester (EME) into hair from blood. At first, the time courses of three drugs in rat plasma following i.p. administration of cocaine were investigated over 360 min. AUCs of COC, BE and EME in plasma were 14.2, 60.7 and 53.4 microgram...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02035137
更新日期:1992-01-01 00:00:00
abstract::In recent years test systems have been described that may be applied routinely to discriminate between contact allergens and irritants in vitro. Using human monocyte-derived dendritic cells (MoDC), this study was designed to refine the settings of a potential routine screening protocol for contact allergens and to inv...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0606-8
更新日期:2005-01-01 00:00:00
abstract::Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316578
更新日期:1984-03-01 00:00:00
abstract::As Drosophila melanogaster occupies an important position within the test battery for mutagens and carcinogens, it is of interest to study the xenobiotics metabolism of this insect. Likewise, the genetic control of these important enzyme systems falls within this interest. Our attempt was to get new strains, which sho...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316345
更新日期:1984-11-01 00:00:00
abstract::We investigated the influence of the dopamine antagonist haloperidol on the neurotransmitter content in the developing rat brain. Dopamine (DA), serotonin (5-HT) and the corresponding metabolites dopac, HVA and HIAA were determined in the corpus striatum of the rat between day 1 and day 21 pn by HPLC with electro-chem...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973388
更新日期:1992-01-01 00:00:00
abstract::3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0657-6
更新日期:2011-10-01 00:00:00
abstract::Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxic...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00297587
更新日期:1980-01-01 00:00:00