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No more non-model species: the promise of next generation sequencing for comparative immunology.

Abstract：

:Next generation sequencing (NGS) allows for the rapid, comprehensive and cost effective analysis of entire genomes and transcriptomes. NGS provides approaches for immune response gene discovery, profiling gene expression over the course of parasitosis, studying mechanisms of diversification of immune receptors and investigating the role of epigenetic mechanisms in regulating immune gene expression and/or diversification. NGS will allow meaningful comparisons to be made between organisms from different taxa in an effort to understand the selection of diverse strategies for host defence under different environmental pathogen pressures. At the same time, it will reveal the shared and unique components of the immunological toolkit and basic functional aspects that are essential for immune defence throughout the living world. In this review, we argue that NGS will revolutionize our understanding of immune responses throughout the animal kingdom because the depth of information it provides will circumvent the need to concentrate on a few "model" species.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Dheilly NM,Adema C,Raftos DA,Gourbal B,Grunau C,Du Pasquier L

doi

10.1016/j.dci.2014.01.022

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

56-66

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(14)00029-9

journal_volume

45

pub_type

杂志文章,评审

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