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An inducible transgene reports activation of macrophages in live zebrafish larvae.

Abstract：

:Macrophages are the most functionally heterogenous cells of the hematopoietic system. Given many diseases are underpinned by inappropriate macrophage activation, macrophages have emerged as a therapeutic target to treat disease. A thorough understanding of what controls macrophage activation will likely reveal new pathways that can be manipulated for therapeutic benefit. Live imaging fluorescent macrophages within transgenic zebrafish larvae has provided a valuable window to investigate macrophage behavior in vivo. Here we describe the first transgenic zebrafish line that reports macrophage activation, as evidenced by induced expression of an immunoresponsive gene 1(irg1):EGFP transgene. When combined with existing reporter lines that constitutively mark macrophages, we reveal this unique transgenic line can be used to live image macrophage activation in response to the bacterial endotoxin lipopolysaccharide and xenografted human cancer cells. We anticipate the Tg(irg1:EGFP) line will provide a valuable tool to explore macrophage activation and plasticity in the context of different disease models.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Sanderson LE,Chien AT,Astin JW,Crosier KE,Crosier PS,Hall CJ

doi

10.1016/j.dci.2015.06.013

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

63-9

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(15)30001-X

journal_volume

53

pub_type

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