Abstract:
:To date two closely related interleukin-1β genes (IL-1β1 and IL-β2) have been found in salmonids. The cloning of trout and salmon IL-1β3, and a salmon IL-1β4 pseudogene reveals that two types of IL-1β genes exist in teleost species. Type I teleost IL-1β genes, including salmonid IL-1β3, share a similar 6 coding exon structure as in tetrapods. Type II teleost IL-1β genes, e.g. salmonid IL-1β1-2, lack one or two coding exons at their 5'-end, and share higher identities within this subgroup than within the type I subgroup. Both types of IL-1β genes have been found in species of Salmoniformes, Perciformes and Beloniformes, suggesting the divergence occurred early in teleost evolution. Trout IL-1β3 is highly expressed in ovary suggesting a role in reproduction. A relatively high constitutive expression in gills, spleen and kidney and the up-regulation by PAMPs, proinflammatory cytokines and viral infection suggests IL-1β3 also has a role in inflammation and host defence.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Husain M,Bird S,van Zwieten R,Secombes CJ,Wang Tdoi
10.1016/j.dci.2012.07.010subject
Has Abstractpub_date
2012-11-01 00:00:00pages
431-46issue
3eissn
0145-305Xissn
1879-0089pii
S0145-305X(12)00170-Xjournal_volume
38pub_type
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