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Identification of a second immunoglobulin in the most primitive shark, the frill shark, Chlamydoselachus anguineus.

Abstract：

:Three molecular forms of immunoglobulins: pentamer, dimer and monomer, were isolated from serum of the frill shark, Chlamydoselachus anguineus, the most primitive extant shark. A pentamer having an apparent mass of 900 kDa, consisting of 68 kDa heavy (H) chains and 22-24 kDa light (L) chains, was considered to be IgM because of its similarity to mammalian IgM in both molecular form and H chain molecular weight. The dimer and monomer with apparent masses of 300 kDa and 150 kDa, respectively, were composed of the same H chains of 45-50 kDa, a value smaller than that of the H chains from the pentamer, and light chains identical to those of the pentamer. The H chains of 68 kDa and 45-50 kDa represented individual epitopes and were synthesized by different plasma cells. We thus concluded that the frill shark has two distinct classes of immunoglobulins: one a pentameric IgM and the other a second class of immunoglobulin with dimeric and monomeric structure. The presence of the second Ig is of considerable interest with respect to antigen recognition and exclusion.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Kobayashi K,Tomonaga S,Tanaka S

doi

10.1016/0145-305x(92)90004-v

keywords:

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

295-9

issue

4

eissn

0145-305X

issn

1879-0089

pii

0145-305X(92)90004-V

journal_volume

16

pub_type

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