当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > IL-12 and IL-18 induce interferon-γ production and de novo CD2 expression in porcine γδ T cells.

IL-12 and IL-18 induce interferon-γ production and de novo CD2 expression in porcine γδ T cells.

Abstract：

:γδ T cells are highly abundant in the blood and spleen of pigs but little is known about their functional differentiation. In this study the potential of the type-1 polarizing cytokines IL-12 and IL-18 in combination with IL-2 and Concanavalin A (ConA) to stimulate porcine γδ T cells was investigated. Stimulation of purified γδ T cells with ConA and IL-2 induced a strong proliferation of CD2(-) γδ T cells, whereas additional stimulation with IL-12 and IL-18 caused a stronger proliferation of CD2(+) γδ T cells. IFN-γ could only be detected in supernatants of γδ T-cell cultures supplemented with IL-12 and IL-18. Experiments with sorted CD2/SWC5-defined γδ T-cell subsets revealed that CD2(+)SWC5(-) γδ T cells are the main producers of IFN-γ following stimulation with IL-2/IL-12/IL-18. Additional stimulation with ConA led to an upregulation of CD2 within the CD2(-) γδ T cell subsets, indicating a previously unnoticed plasticity of CD2-defined γδ T cell subsets.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Sedlak C,Patzl M,Saalmüller A,Gerner W

doi

10.1016/j.dci.2014.07.007

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

115-22

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(14)00188-8

journal_volume

47

pub_type

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