abstract：:Toll/interleukin 1 receptor domain-containing adaptor protein (TIRAP) and toll/interleukin 1 receptor-domain-containing adapter-inducing interferon-β (TRIF) are crucial adaptors of signal transduction for the signaling pathways of toll-like receptors (TLRs). TIRAP and TRIF perform an essential function in an antimicro...

journal_title：Developmental and comparative immunology

authors： Trung NB,Nan FH,Wang IJ,Wu YC,Wen CM,Lee MC,Hang HT,Lee PT

更新日期：2021-04-01 00:00:00

abstract：:Toll-like receptors (TLRs)are pattern recognition receptors (PRRs) that are important in invertebrate innate immunity for the recognition and elimination of pathogens. Although they were reported in many fishes, Toll-like receptors subfamily contain a large number of members with different functions that need to resea...

journal_title：Developmental and comparative immunology

authors： Wu M,Zhu KC,Guo HY,Guo L,Liu B,Jiang SG,Zhang DC

更新日期：2021-04-01 00:00:00

abstract：:Cytidine/uridine monophosphate kinase 2 (CMPK2) is a thymidylate kinase and in mammals is known to be involved in mitochondrial DNA (mtDNA) synthesis and antiviral immunity. However, very little is known about the function of CMPK2 in fish. With an aim to elucidate the antimicrobial mechanism of CMPK2 in fish, we in t...

journal_title：Developmental and comparative immunology

authors： Feng C,Tang Y,Liu X,Zhou Z

更新日期：2021-03-01 00:00:00

abstract：:The chemokine signaling axes CCR2-CCL2 and CXCR3-CXCL11 participate in the inflammatory response by recruiting leukocytes to damaged tissue or sites of infection and are, therefore, potential pharmacological targets to treat inflammatory disorders. Although multiple CCR2 orthosteric and allosteric inhibitors have been...

journal_title：Developmental and comparative immunology

authors： Sommer F,Ortiz Zacarı As NV,Heitman LH,Meijer AH

更新日期：2021-03-01 00:00:00

abstract：:The four-and-a-half LIM-only protein family of transcription co-factors participates in various cellular processes, such as cell proliferation, cell differentiation, apoptosis, cell adhesion, migration, transcription and signal transduction. However, the knowledge of the structural characteristics and immune functions...

journal_title：Developmental and comparative immunology

authors： Xu L,Zhou X,Wang P,Jin Q,Zhu T,Chen M,Xu H

更新日期：2021-03-01 00:00:00

abstract：:DM9 domain containing protein (DM9CP) is a recently identified pattern recognition molecules exiting in most organisms except plants. In the present study, a novel DM9-containing protein (CgDM9CP-3) was identified from Pacific oyster Crassostrea gigas with an open reading frame of 438 bp, encoding a polypeptide of 145...

journal_title：Developmental and comparative immunology

authors： Liu Y,Wang W,Zhao Q,Yuan P,Li J,Song X,Liu Z,Ding D,Wang L,Song L

更新日期：2021-03-01 00:00:00

abstract：:Cathepsins belongs to the cysteine protease family, which are activated by an acidic environment. They play essential biological roles in the innate immunity and development of animals. Here, we identified a 62 kDa cathepsin L-like protease from the silkworm Bombyx mori. It contained putative conserved domains, includ...

journal_title：Developmental and comparative immunology

authors： Sun YX,Chen C,Xu WJ,Abbas MN,Mu FF,Ding WJ,Zhang HJ,Li J

更新日期：2021-03-01 00:00:00

abstract：:Forkhead-box O (FoxO) is the primary transcriptional effector of the insulin-like signaling pathway that enhances gluconeogenesis through transcriptional activation of PEPCK and G6Pase in mammals. We have previously demonstrated the involvement of phosphoenolpyruvate carboxykinase (BmPEPCK-2) in antiviral immunity aga...

journal_title：Developmental and comparative immunology

authors： Kang X,Wang Y,Liang W,Tang X,Zhang Y,Wang L,Zhao P,Lu Z

更新日期：2021-03-01 00:00:00

abstract：:Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that caused severe egg drop syndrome in laying ducks in China since 2010, leading to massive economic losses to the duck industry. Although the DTMUV E protein is considered to be critical in inducing the protective immune response, the functional ep...

journal_title：Developmental and comparative immunology

authors： Gong H,Fan Y,Zhou P,Li Y,Hu X,Jin H,Luo R

更新日期：2021-02-01 00:00:00

abstract：:Immune checkpoint immunotherapy is a pillar of human oncology treatment with potential for non-human species. The first checkpoint immunotherapy approved for human cancers targeted the CTLA4 protein. CTLA4 can inhibit T cell activation by capturing and internalizing CD80 and CD86 from antigen presenting cells, a proce...

journal_title：Developmental and comparative immunology

authors： Wong C,Darby JM,Murphy PR,Pinfold TL,Lennard PR,Woods GM,Lyons AB,Flies AS

更新日期：2021-02-01 00:00:00

abstract：:Ticks, being obligate hematophagous arthropods, are exposed to various blood-borne pathogens, including arboviruses. Consequently, their feeding behavior can readily transmit economically important viral pathogens to humans and animals. With this tightly knit vector and pathogen interaction, the replication and transm...

journal_title：Developmental and comparative immunology

authors： Talactac MR,Hernandez EP,Hatta T,Yoshii K,Kusakisako K,Tsuji N,Tanaka T

更新日期：2021-01-21 00:00:00

abstract：:There has been a longstanding question of whether affinity maturation occurs in ectotherms, and if it does, where in tissues this happens. Although cold-blooded vertebrates (ectotherms) lack histologically discernible germinal centers, they have a fully functional Ig gene mutator enzyme (activation-induced cytidine de...

journal_title：Developmental and comparative immunology

authors： Muthupandian A,Waly D,Magor BG

更新日期：2021-01-19 00:00:00

abstract：:Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in North America, has decimated bat populations within a decade. The fungus impacts bats during hibernation when physiological functions, including immune responses, are down-regulated. Studies have shown that Pd is native to Europe, where i...

journal_title：Developmental and comparative immunology

authors： Fritze M,Puechmaille SJ,Costantini D,Fickel J,Voigt CC,Czirják GÁ

更新日期：2021-01-18 00:00:00

abstract：:CD3 is an essential component of the TCR-CD3 complex which plays a key role in adaptive immunity. Non-mammalian CD3 complex consists of CD3γ/δ, CD3ε and CD3ζ subunits. In this study, homologues of CD3γ/δ and CD3ε (termed CiCD3γ/δ and CiCD3ε) have been identified in grass carp (Ctenopharyngodon idella). Like their coun...

journal_title：Developmental and comparative immunology

authors： Qin Y,Sun Z,Wang W,Xu J,Wang B,Jia Z,Li X,Wang J,Gao Q,Chen X,Zou J

更新日期：2021-01-01 00:00:00

abstract：:Kazal-type serine proteinase inhibitors (KPIs) function in physiological and immunological processes requiring proteinase action. In the present study, the first Cherax quadricarinatus KPI gene (designated CqKPI) was identified and characterized. The open reading frame of CqKPI contains 405 nucleotides and encodes a p...

journal_title：Developmental and comparative immunology

authors： Wang Y,Wang B,Liu M,Jiang K,Wang M,Wang L

更新日期：2021-01-01 00:00:00

abstract：:In vertebrates, a total of eleven interferon (IFN) regulatory factors (IRFs), IRF1 to IRF11 are reported, with the conserved presence of IRF1 to IRF9 in all classes of vertebrates. However, IRF10 has been reported only in fish and birds, and IRF11 seems to be a fish specific IRF member. In this study, IRF11 in mandari...

journal_title：Developmental and comparative immunology

authors： Li L,Chen SN,Nie P

更新日期：2021-01-01 00:00:00

abstract：:The human IL-1 receptor family is comprised of 11 membrane bound or soluble receptors and the IL-18 binding protein (IL-18BP). These receptors are dispersed across seven genomic loci, with the majority at a single locus. Direct orthologues were identified in the chicken at conserved genomic loci; however, the IL-18BP ...

journal_title：Developmental and comparative immunology

authors： Gibson MS,Steyn A,Kealy D,Kaspers B,Fife MS

更新日期：2021-01-01 00:00:00

abstract：:The signal transducer and activator of transcription (STAT), as an important transcription factor of the Janus kinase (JAK)-STAT signaling pathway, is pivotal for development and immunity and well documented in vertebrates. However, the STAT gene has not been reported in chordate amphioxus (Branchiostoma belcheri). In...

journal_title：Developmental and comparative immunology

authors： Cao Y,Fang T,Fan M,Wang L,Lv C,Xiaojun Song,Jin P,Ma F

更新日期：2021-01-01 00:00:00

abstract：:Brief pretreatment of cold shock at 13 °C for 3 min proved to be an inducer of heat shock protein 70 (HSP70) and improved stress tolerance as a molecular chaperone. With the improvement of air exposure tolerance, HSP70 in shrimp hemocytes was upregulated in mRNA and protein levels after cold shock. Both HSP70 RNA inte...

journal_title：Developmental and comparative immunology

authors： Guan W,Wei X,Nong W,Shao Y,Mao L

更新日期：2021-01-01 00:00:00

abstract：:Recent reports demonstrate that octopamine plays an important immunological role in crowded larvae of the Oriental Armyworm, Mythmina separata. We identified an octopamine receptor, the β-adrenergic-like gene (designated MsOctβ2R), with a 1191 bp open reading frame that encodes 396 amino acids and contains seven conse...

journal_title：Developmental and comparative immunology

authors： Kong H,Yuan L,Dong C,Zheng M,Jing W,Tian Z,Hou Q,Cheng Y,Zhang L,Jiang X,Luo L

更新日期：2020-12-01 00:00:00

abstract：:The differentiation of distinct leukocyte subsets is governed by lineage-specific growth factors that elicit disparate expression of transcription factors and markers by the developing cell populations. For example, macrophages (Mφs) and granulocytes (Grns) arise from common granulocyte-macrophage progenitors in respo...

journal_title：Developmental and comparative immunology

authors： Yaparla A,Koubourli DV,Popovic M,Grayfer L

更新日期：2020-12-01 00:00:00

abstract：:In mammals, tripartite motif (TRIM)-containing proteins are involved in interferon (IFN)-mediated antiviral response as pivotal players endowed with antiviral effects and modulatory capacity. Teleost fish have a unique subfamily of TRIM, called finTRIM (fish novel TRIM, FTR) generated by genus- or species-specific dup...

journal_title：Developmental and comparative immunology

authors： Li YL,Zhao X,Gong XY,Dan C,Gui JF,Zhang YB

更新日期：2020-12-01 00:00:00

abstract：:Small heat shock proteins are a molecular chaperone and implicated in various physiological and stress processes in animals. However, the immunological functions of Hsp genes remain to elucidate in the crustaceans, particularly in red swamp crayfish, Procambarus clarkii. Here we report the cloning of heat shock protei...

journal_title：Developmental and comparative immunology

authors： Dai LS,Kausar S,Gul I,Zhou HL,Abbas MN,Deng MJ

更新日期：2020-10-01 00:00:00

abstract：:The ecdysone, 20-hydroxyecdysone (20E) and ecdysone receptor (EcR), are regarded as the key regulators of development, metamorphosis, and growth in arthropods. In the present study, the role of 20E and EsEcR in regulating the expression of antimicrobial peptides (AMPs) was investigated in Chinese mitten crab, Eriochei...

journal_title：Developmental and comparative immunology

authors： Huang S,Yi Q,Lian X,Xu S,Yang C,Sun J,Wang L,Song L

更新日期：2020-10-01 00:00:00

abstract：:In the present study, we developed an O-antigen-deficient, live, attenuated Salmonella Typhimurium (ST) strain (JOL2377) and assessed its safety, macrophage toxicity, invasion into lymphoid tissues, immunogenicity, and protection against Salmonella infection in chickens. The JOL2377 induced significantly lower cytotox...

journal_title：Developmental and comparative immunology

authors： Senevirathne A,Hewawaduge C,Park S,Park JY,Kirthika P,Lee JH

更新日期：2020-10-01 00:00:00

abstract：:Receptor-interacting serine/threonine protein kinase 1 (RIPK1) is an important regulator of necroptosis and involved in innate immune response in human and mammal; however, its function in teleost fish mains largely unknown. In this paper, the RIPK1 homologue of black carp (Mylopharyngodon piceus) has been cloned and ...

journal_title：Developmental and comparative immunology

authors： Xie X,Cao Y,Dai Y,Chen Z,Wei J,Tan Y,Wu H,Feng H

更新日期：2020-08-01 00:00:00

abstract：:The respiratory glycoprotein, hemocyanin (HMC) has multiple immune-related functions, including antiviral activity. In this study, in silico methods were used to predict seven miRNAs targeting Litopenaeus vannamei HMC (LvHMC), out of which miR-589-5p was selected for further investigation because of its role in immune...

journal_title：Developmental and comparative immunology

authors： Bao S,Zheng Z,Aweya JJ,Yao D,Li S,Sun C,Hong Y,Zhang Y

更新日期：2020-06-01 00:00:00

abstract：:Hemocyanin is a respiratory protein that possesses multiple physiological and immunological functions in shrimp. However, the transcriptional regulation of the hemocyanin gene is still poorly understood. Here, the nuclear receptor E75 of Litopenaeus vannamei (LvE75) was identified as one of the transcriptional regulat...

journal_title：Developmental and comparative immunology

authors： Zhang Z,Yao D,Yang P,Zheng Z,Aweya JJ,Lun J,Ma H,Zhang Y

更新日期：2020-06-01 00:00:00

abstract：:Thioredoxin-like protein 5 (Trxlp-5) is a thioredoxin isoform associated with cellular redox homeostasis through the activity of thiol-disulfide reductase. In our study, Trxlp-5 was identified and characterized in Pinctada fucata martensii. The expression of PmTrxlp-5 was detected in response to polyinosinic: polycyti...

journal_title：Developmental and comparative immunology

authors： Adzigbli L,Zheng Z,Liao Y,Deng Y,Du X,Yang C

更新日期：2020-05-01 00:00:00

abstract：:Acute hepatopancreatic necrosis disease (AHPND) is a recently emerged disease in aqua cultured shrimp that is caused by virulent strains of Vibrio parahaemolyticus (VP). Our previous study used transcriptomics to identify key pathogenic factors in the stomach of AHPND-infected shrimp (Litopenaeus vannamei), and here w...

journal_title：Developmental and comparative immunology

authors： Apitanyasai K,Chang CC,Ng TH,Ng YS,Liou JH,Lo CF,Lin SS,Wang HC

更新日期：2020-05-01 00:00:00

abstract：:Regulation of immune responses in animals is largely governed by the JAK-STAT and NF-κB pathways, which are conserved across vertebrates and invertebrates. At present, the relationship between these two pathways in invertebrates remains unclear. In the current study, a novel antimicrobial peptide termed LvSWD5 belongi...

journal_title：Developmental and comparative immunology

authors： Yang L,Luo M,Guo Z,Zuo H,Weng S,He J,Xu X

更新日期：2020-03-01 00:00:00

abstract：:This study characterizes immunoglobulin light chain (IgL) expression and variable family usage in rainbow trout. IgL transcripts were generated by 5' RACE from both immune and TNP-KLH immunized fish. Phylogenetic analysis revealed that the IgL variable regions clustered into seven different families: three kappa famil...

journal_title：Developmental and comparative immunology

authors： Rego K,Bengtén E,Wilson M,Hansen JD,Bromage ES

更新日期：2020-03-01 00:00:00

abstract：:Mannose-binding lectin (MBL) plays an important role in host immune responses against pathogens. LjMBL-like-1 was identified from Japanese sea bass (Lateolabrax japonicas), which has selectivity for galactose. Herein, this lectin might be better designated as galactose-binding lectin (LjGalBL-1). LjGalBL-1 transcripts...

journal_title：Developmental and comparative immunology

authors： Dang Y,Nie L,Chen J

更新日期：2020-03-01 00:00:00

abstract：:Insect hemocyte and fat body tissues play critical functional roles in insect immunity. Little, however, is known concerning the dynamic responses of these tissues to fungal infection. Here, we report on a time course of locust hemocyte and fat body transcriptomic responses to infection by the acridid specific fungal ...

journal_title：Developmental and comparative immunology

authors： Zhang W,Zheng X,Chen J,Keyhani NO,Cai K,Xia Y

更新日期：2020-03-01 00:00:00

abstract：:Since the 1990s White Spot Syndrome Virus (WSSV) has severely affected shrimp aquaculture worldwide causing a global pandemic of White Spot Disease (WSD) in penaeid culture. However, not all decapod species that can be infected by WSSV show the same susceptibility to the virus, thus raising interesting questions regar...

journal_title：Developmental and comparative immunology

authors： Peruzza L,Thamizhvanan S,Vimal S,Vinaya Kumar K,Shekhar MS,Smith VJ,Hauton C,Vijayan KK,Sahul Hameed AS

更新日期：2020-03-01 00:00:00

abstract：:β-defensins (BD) are the largest family of vertebrate defensins with potent antimicrobial, chemotactic and immune-regulatory activities. Four BD genes (BD1-4) have been cloned previously in rainbow trout but none have been reported in other salmonids. In this study seven BD genes (BD1a-b, 2-4, 5a-b) are characterised ...

journal_title：Developmental and comparative immunology

authors： Harte A,Tian G,Xu Q,Secombes CJ,Wang T

更新日期：2020-03-01 00:00:00

abstract：:Scavenger receptors (SRs) are pattern recognition receptors (PRRs) vital for innate immunity. As well as their importance in immune recognition, microbe phagocytosis, and the clearance of modified endogenous molecules, they also activate downstream immune responses as co-receptors. In the current study, we identified ...

journal_title：Developmental and comparative immunology

authors： Tang M,Li X,Yang L,Wang Q,Li W

更新日期：2020-02-01 00:00:00

abstract：:Chemokines refer to chemoattractant cytokines, which have crucial functions in inflammation and immune responses in multiple cellular processes. In the present study, we described the potential role of porcine CCL5 in embryo implantation and fetal-maternal environment during early pregnancy. We first carried out phylo...

journal_title：Developmental and comparative immunology

authors： Bae H,Lee JY,Song G,Lim W

更新日期：2020-02-01 00:00:00

abstract：:Mammalian CCL20, or macrophage inflammatory protein-3α, can function as a homeostatic and inflammatory chemokine. In relation to the latter, it is responsible for the chemoattraction of lymphocytes and dendritic cells to mucosal immune sites under inflammatory and pathological conditions. CK1, CK8A and CK8B are rainbo...

journal_title：Developmental and comparative immunology

authors： Liu F,Wang T,Hu Y,Tian G,Secombes CJ,Wang T

更新日期：2020-02-01 00:00:00

abstract：:Serious juvenile oyster disease induced by pathogenic Vibrio splendidus has resulted in tremendous economic loss, but the molecular mechanisms underlying this killing mechanism remain unclear. The resistance of adult oyster to V. splendidus or its virulence factors might provide a possible access to cognize the intera...

journal_title：Developmental and comparative immunology

authors： Wang W,Lv X,Liu Z,Song X,Yi Q,Wang L,Song L

更新日期：2020-01-01 00:00:00